646

Lipopolysaccharides, from E. coli O55:B5

646 Publications Verification

Synonyms: LPS, from Escherichia coli (O55:B5)

Category:

Natural Products Microorganisms Disease Research Fields Inflammation/Immunology

Target:

Lipopolysaccharides, from E. coli O55:B5 (LPS, from Escherichia coli (O55:B5)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O55:B5) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O55:B5 possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activate TLR-4 in immune cells, exhibit high pyrogenicity, and demonstrate dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 can be widely used to induce cellular inflammation and establish animal models related to inflammation .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

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183

Docetaxel

183 Cited Publications

Cat. No.: HY-B0011

CAS No.: 114977-28-5

Synonyms: RP-56976

Category:

Terpenoids Diterpenoids Endogenous metabolite Disease Research Fields Cancer

Target:

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Docetaxel (RP-56976) is an orally active tubulin stabilizer with antitumor activity. Docetaxel is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel can be used in cancer-related research .

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183

Docetaxel Trihydrate

183 Cited Publications

Cat. No.: HY-B0011A

CAS No.: 148408-66-6

Synonyms: RP-56976 Trihydrate

Target:

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Research Areas:

Cancer

Docetaxel Trihydrate (RP-56976 Trihydrate) is an orally active tubulin stabilizer with antitumor activity. Docetaxel Trihydrate is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel Trihydrate binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel Trihydrate induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel Trihydrate induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel Trihydrate can be used in cancer-related research .

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85

2-Aminoethyl diphenylborinate

85 Cited Publications

Cat. No.: HY-W009724

CAS No.: 524-95-8

Synonyms: 2-APB

Target:

Calcium Channel TRP Channel CRAC Channel

Research Areas:

Cardiovascular Disease Inflammation/Immunology

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca ²⁺ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue .

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21

BAY-3827

21 Cited Publications

Cat. No.: HY-112083

CAS No.: 2377576-35-5

Purity: 99.66%

Target:

AMPK

Research Areas:

Cancer

BAY-3827, a chemical probe, is a potent and selective AMPK inhibitor with IC₅₀ values of 1.4 nM at low (10 μM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines .

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21

MQAE

21 Cited Publications

Cat. No.: HY-D0090

CAS No.: 162558-52-3

Target:

Fluorescent Dye

Research Areas:

Others

MQAE is a chloride ion (Cl ^-) fluorescent probe that can be used to measure chloride concentrations. The fluorescence intensity of MQAE decreases proportionally as Cl ^- ions increase. MQAE has high cell permeability and is suitable for fluorescence detection such as confocal microscopy and flow cytometry (Ex/Em=350/460 nm) .

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