65 Results for "

high oral bioavailability

" in MedChemExpress (MCE) Product Catalog:
Products (65)

65 Results for "high oral bioavailability" in MCE Product Catalog:

38
Dolutegravir
Dolutegravir
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38 Publications Verification
Cat. No.: HY-13238
CAS No.: 1051375-16-6
Purity:  99.85%
Synonyms: S/GSK1349572
Target:  

HIV Integrase HIV

Research Areas:  

Infection

Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM) .
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38
Dolutegravir sodium
Dolutegravir sodium
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38 Publications Verification
Cat. No.: HY-13238A
CAS No.: 1051375-19-9
Purity:  99.97%
Synonyms: S/GSK1349572 sodium
Target:  

HIV Integrase HIV

Research Areas:  

Infection

Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM) .
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18
BI-749327
BI-749327
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18 Cited Publications
Cat. No.: HY-111925
CAS No.: 2361241-23-6
Purity:  99.91%
Target:  

TRP Channel

Research Areas:  

Cardiovascular Disease

BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7 .
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6
Tocofersolan
Tocofersolan
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6 Cited Publications
Cat. No.: HY-B0717
CAS No.: 9002-96-4
Synonyms: TPGS; D-α-Tocopherol polyethylene glycol 1000 succinate; Vitamin E-TPGS
Target:  

Drug Derivative

Research Areas:  

Infection Neurological Disease Metabolic Disease

Tocofersolan is synthetic polyethylene glycol derivative of α-tocopherol. Tocofersolan is an orally active and water-soluble analog of vitamin E. Tocofersolan can reduce neurobehavioral deficits in zebrafish embryos exposed to moderate and high concentrations of BaP during early development. Tocofersolan shows antioxidant activity. Tocofersolan can be used to provide an orally bioavailable source of vitamin E .
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5
RS-127445 hydrochloride
RS-127445 hydrochloride
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5 Cited Publications
Cat. No.: HY-15419
CAS No.: 199864-86-3
Purity:  99.78%
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 hydrochloride shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites .
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5
PZ-2891
PZ-2891
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5 Cited Publications
Cat. No.: HY-124634
CAS No.: 2170608-82-7
Purity:  99.68%
Target:  

PANK

Research Areas:  

Neurological Disease

PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively .
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5
M3258
M3258
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5 Cited Publications
Cat. No.: HY-111790
CAS No.: 2285330-15-4
Purity:  ≥98.0%
Target:  

Proteasome Apoptosis

Research Areas:  

Cancer

M3258 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor. M3258 exerts high biochemical (IC50=3.6 nM) and cellular (IC50=3.4 nM) potency against the LMP7 subunit. M3258 shows strong antitumor efficacy in multiple myeloma xenograft models. M3258 leads to a significant and prolonged suppression of tumor LMP7 activity and ubiquitinated protein turnover and the induction of apoptosis in multiple myeloma cells .
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5
RS-127445
RS-127445
0 Images
5 Cited Publications
Cat. No.: HY-15419A
CAS No.: 199864-87-4
Purity:  99.62%
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

RS-127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites .
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3
JNJ-55308942
JNJ-55308942
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3 Cited Publications
Cat. No.: HY-123857
CAS No.: 2166558-11-6
Purity:  99.82%
Target:  

P2X Receptor

Research Areas:  

Neurological Disease Inflammation/Immunology

JNJ-55308942 is a high-affinity, selective, brain-penetrant P2X7 functional antagonist (hP2X7: IC50=10 nM, Ki=7.1 nM; rP2X7: IC50=15 nM, Ki=2.9 nM). JNJ-55308942 is orally bioavailable, binds to brain P2X7 and blocks IL-1β release from adult rodent brain .
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1
Dermatan sulphate sodium
Dermatan sulphate sodium
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1 Cited Publications
Cat. No.: HY-N8278
CAS No.: 54328-33-5
Category:  

Natural Products Animals Disease Research Fields Inflammation/Immunology

Target:  

Thrombin

Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin (HY-108345). Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation .
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1
L-371,257
L-371,257
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1 Cited Publications
Cat. No.: HY-15010
CAS No.: 162042-44-6
Purity:  99.90%
Target:  

Oxytocin Receptor Vasopressin Receptor

Research Areas:  

Cardiovascular Disease Endocrinology

L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor (Ki=19 nM) and vasopressin V1a receptor (Ki=3.7 nM) .
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ELN-441958
ELN-441958
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Cat. No.: HY-15043
CAS No.: 913064-47-8
Purity:  99.51%
Target:  

Bradykinin Receptor

Research Areas:  

Inflammation/Immunology Endocrinology

ELN-441958 is a potent, neutral, competitive and selective bradykinin B1 receptor antagonist with a Ki of 0.26 nM against native human bradykinin B1 receptor. ELN-441958 has high oral bioavailability, and has low CNS exposure in the mouse .
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3',4'-Dihydroxyacetophenone
3',4'-Dihydroxyacetophenone
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Cat. No.: HY-N1775
CAS No.: 1197-09-7
Synonyms: 3,4-DHAP
Category:  

Phenols Polyphenols Plants Pinaceae Extract 500 - Internal Server Error | MedChemExpress

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