108 Results for "

high-fat

" in MedChemExpress (MCE) Product Catalog:
Products (108)

108 Results for "high-fat" in MCE Product Catalog:

31
Nicotinamide riboside chloride
Nicotinamide riboside chloride
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31 Publications Verification
Cat. No.: HY-123033A
CAS No.: 23111-00-4
Purity:  99.90%
Category:  

Alkaloids Neurological Disease Animals Anti-aging Pyridine Alkaloids Metabolic Disease Disease Research Fields

Target:  

Sirtuin Endogenous Metabolite

Nicotinamide riboside Chloride, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .
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31
Nicotinamide riboside malate
Nicotinamide riboside malate
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31 Publications Verification
Cat. No.: HY-123033C
CAS No.: 2415659-01-5
Purity:  98.04%
Category:  

Natural Products Neurological Disease Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Sirtuin Endogenous Metabolite

Nicotinamide riboside malate, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .
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31
Nicotinamide riboside tartrate
Nicotinamide riboside tartrate
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31 Publications Verification
Cat. No.: HY-123033B
CAS No.: 2415657-86-0
Category:  

Natural Products Neurological Disease Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Sirtuin Endogenous Metabolite

Nicotinamide riboside tartrate, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .
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17
CTPI-2
CTPI-2
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17 Cited Publications
Cat. No.: HY-123986
CAS No.: 68003-38-3
Purity:  99.95%
Target:  

Mitochondrial Metabolism

Research Areas:  

Inflammation/Immunology Cancer

CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 μM. CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity .
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10
10,12-Tricosadiynoic acid
10,12-Tricosadiynoic acid
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10 Cited Publications
Cat. No.: HY-135425
CAS No.: 66990-30-5
Purity:  99.05%
Target:  

Acyltransferase

Research Areas:  

Metabolic Disease

10,12-Tricosadiynoic acid is a highly specific, selective, high affinity and orally active acyl-CoA oxidase-1 (ACOX1) inhibitor. 10,12-Tricosadiynoic acid can treat high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism . 10,12-Tricosadiynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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9
E6446 dihydrochloride
E6446 dihydrochloride
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9 Cited Publications
Cat. No.: HY-12756A
CAS No.: 1345675-25-3
Purity:  99.96%
Target:  

Toll-like Receptor (TLR) Stearoyl-CoA Desaturase (SCD)

Research Areas:  

Metabolic Disease Inflammation/Immunology

E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) .
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9
E6446
E6446
0 Images
9 Cited Publications
Cat. No.: HY-12756
CAS No.: 1219925-73-1
Purity:  ≥98.0%
Target:  

Toll-like Receptor (TLR) Stearoyl-CoA Desaturase (SCD)

Research Areas:  

Metabolic Disease Inflammation/Immunology

E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) .
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6
N-Acetylneuraminic acid
N-Acetylneuraminic acid
0 Images
6 Cited Publications
Cat. No.: HY-I0400
CAS No.: 131-48-6
Synonyms: NANA; Lactaminic acid
Category:  

Cardiovascular Disease Endogenous metabolite Disease Research Fields Saccharides Monosaccharides

Target:  

Tyrosinase Ras Influenza Virus Endogenous Metabolite

N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .
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4
KY19382
KY19382
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4 Cited Publications
Cat. No.: HY-131447
CAS No.: 2226664-93-1
Purity:  ≥98.0%
Synonyms: A3051
Target:  

GSK-3 Wnt β-catenin

Research Areas:  

Metabolic Disease

KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases .
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3
TMPA
TMPA
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3 Cited Publications
Cat. No.: HY-18555
CAS No.: 1258275-73-8
Target:  

Nuclear Hormone Receptor 4A/NR4A AMPK

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPKα. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation .
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3
Malabaricone C
Malabaricone C
0 Images
3 Cited Publications
Cat. No.: HY-N8518
CAS No.: 63335-25-1
Category:  

Metabolic Disease Phenols Polyphenols Plants 500 - Internal Server Error | MedChemExpress

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