22

22 Cited Publications

Synonyms: Ergamine

Category:

Human Gut Microbiota Metabolites Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Histamine Receptor p38 MAPK Akt Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite

Histamine is the agonist for histamine receptor and a vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

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399

Dimethyl sulfoxide, meets analytical specification of Ch.P.

399 Publications Verification

Cat. No.: HY-Y0320

CAS No.: 67-68-5

Synonyms: DMSO, meets analytical specification of Ch.P.

Dimethyl sulfoxide (DMSO), meets analytical specification of Ch.P. is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties .
MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition). Amicrobic, low endotoxin, can be used in various biochemical experiments such as drug dissolution.

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66

Dimethyl sulfoxide

66 Cited Publications

Cat. No.: HY-Y0320C

CAS No.: 67-68-5

Synonyms: DMSO

Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity .
Low endotoxin, can be used in various biochemical experiments such as drug dissolution.

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22

Histamine dihydrochloride

22 Cited Publications

Cat. No.: HY-B0722

CAS No.: 56-92-8

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Histamine Receptor p38 MAPK Akt Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite

Histamine dihydrochloride is the agonist for histamine receptor and a vasodilator. Histamine dihydrochloride is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine dihydrochloride affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

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22

Histamine phosphate

22 Cited Publications

Cat. No.: HY-A0129

CAS No.: 51-74-1

Synonyms: histamine diphosphate

Category:

Alkaloids Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Histamine Receptor p38 MAPK Akt Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite

Histamine phosphate is the agonist for histamine receptor and a vasodilator. Histamine phosphate is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine phosphate affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine phosphate can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

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21

Osthole

21 Cited Publications

Cat. No.: HY-N0054

CAS No.: 484-12-8

Synonyms: Osthol; NSC 31868

Category:

Cardiovascular Disease Coumarins Plants Other Families Extract Biological Pesticide Research Agricultural Research Infection Phenylpropanoids Disease Research Fields Inflammation/Immunology Endocrinology

Target:

Histamine Receptor Apoptosis Parasite HBV

Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H₁ receptor activity. Osthole also suppresses the secretion of HBV in cells.

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15

Clemastine

15 Cited Publications

Cat. No.: HY-B0298

CAS No.: 15686-51-8

Synonyms: HS-592; Meclastine

Target:

Histamine Receptor mAChR Autophagy Apoptosis Keap1-Nrf2 p62 mTOR Pyroptosis IKK

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Clemastine (HS-592; Meclastine) is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .

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15

Clemastine fumarate

15 Cited Publications

Cat. No.: HY-B0298A

CAS No.: 14976-57-9

Synonyms: HS-592 fumarate; Meclastine fumarate

Target:

Histamine Receptor Apoptosis mAChR Pyroptosis Keap1-Nrf2 p62 Autophagy mTOR IKK

Research Areas:

Neurological Disease Metabolic Disease

Clemastine (HS-592; Meclastine) fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .

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14

Loratadine

14 Cited Publications

Cat. No.: HY-17043

CAS No.: 79794-75-5

Synonyms: Loratidine; SCH 29851

Target:

Flavivirus Dengue Virus Histamine Receptor

Research Areas:

Infection Inflammation/Immunology Endocrinology Cancer

Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

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14

Desloratadine

14 Cited Publications

Cat. No.: HY-B0539

CAS No.: 100643-71-8

Synonyms: Sch34117

Category:

Disease Research Fields Endocrinology

Target:

Histamine Receptor TNF Receptor Leukotriene Receptor

Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (K_i=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of IL-4 and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria .

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12

Amodiaquine

12 Cited Publications

Cat. No.: HY-B1322A

CAS No.: 86-42-0

Synonyms: Amodiaquin

Target:

Nuclear Hormone Receptor 4A/NR4A Parasite Histone Methyltransferase

Research Areas:

Infection Neurological Disease Inflammation/Immunology

Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

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12

Amodiaquine dihydrochloride dihydrate

12 Cited Publications

Cat. No.: HY-B1322

CAS No.: 6398-98-7

Synonyms: Amodiaquin dihydrochloride dihydrate

Target:

Nuclear Hormone Receptor 4A/NR4A Parasite Histone Methyltransferase

Research Areas:

Infection Neurological Disease Inflammation/Immunology

Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride dihydrate is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

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12

Amodiaquine dihydrochloride

12 Cited Publications

Cat. No.: HY-B1322B

CAS No.: 69-44-3

Synonyms: Amodiaquin dihydrochloride

Target:

Nuclear Hormone Receptor 4A/NR4A Parasite Histone Methyltransferase

Research Areas:

Infection Neurological Disease Inflammation/Immunology

Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor with a K_i of 18.6 nM. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

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11

Cromolyn

11 Cited Publications

Cat. No.: HY-B1619

CAS No.: 16110-51-3

Synonyms: Cromoglycate; Cromoglicic acid; FPL-670 free acid

Target:

GSK-3 NF-κB Amyloid-β

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

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11

Cromolyn disodium

11 Cited Publications

Cat. No.: HY-B0320A

CAS No.: 15826-37-6

Synonyms: Cromoglycate disodium; Cromoglicic acid disodium; FPL-670

Target:

GSK-3 NF-κB Amyloid-β

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

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9

Diphenhydramine hydrochloride

9 Cited Publications

Cat. No.: HY-B0303A

CAS No.: 147-24-0

Target:

Histamine Receptor Bacterial Apoptosis

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) .

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9

Diphenhydramine

9 Cited Publications

Cat. No.: HY-B0303

CAS No.: 58-73-1

Target:

Histamine Receptor Bacterial iGluR

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) .

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9

Astemizole

9 Cited Publications

Cat. No.: HY-12532

CAS No.: 68844-77-9

Purity: 99.77%

Synonyms: R 43512

Target:

Histamine Receptor Potassium Channel

Research Areas:

Inflammation/Immunology Endocrinology

Astemizole (R 43512), a second-generation antihistamine agent to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC₅₀ of 4 nM. Astemizole also shows potent hERG K ⁺ channel blocking activity with an IC₅₀ of 0.9 nM. Astemizole has antipruritic effects .

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