47

Simeprevir

47 Cited Publications

Cat. No.: HY-10241

CAS No.: 923604-59-5

Purity: 98.79%

Synonyms: TMC435; TMC435350

Target:

HCV HCV Protease SARS-CoV DNA/RNA Synthesis

Research Areas:

Infection

Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M ^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

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Olgotrelvir sodium

Cat. No.: HY-156655A

CAS No.: 2763596-72-9

Purity: ≥95.0%

Synonyms: STI-1558 sodium

Target:

SARS-CoV Cathepsin Virus Protease

Research Areas:

Infection

Olgotrelvir (STI-1558) sodium is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin (Cathepsin L). Olgotrelvir sodium is readily converted to its active form, AC1115, in full blood and/or plasma. Olgotrelvir sodium can effectively inhibit both SARS-CoV-2 replication and entry into host cells .

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Olgotrelvir

Cat. No.: HY-156655

CAS No.: 2763596-71-8

Synonyms: STI-1558

Target:

SARS-CoV Virus Protease Cathepsin

Research Areas:

Infection

Olgotrelvir (STI-1558) is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin (Cathepsin L). Olgotrelvir is readily converted to its active form, AC1115, in full blood and/or plasma. Olgotrelvir can effectively inhibit both SARS-CoV-2 replication and entry into host cells .

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SpeB cysteine protease

Cat. No.: HY-E70420

CAS No.: 9025-51-8

Target:

Bacterial

Research Areas:

Inflammation/Immunology

SpeB cysteine protease is a potent modifier of immunologically important host and bacterial proteins. SpeB cysteine protease degrades streptolysin O (SLO) in extracellular vesicles .

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MPI8

Cat. No.: HY-158763

CAS No.: 856242-63-2

Synonyms: TG0205221

Target:

SARS-CoV Cathepsin Virus Protease

Research Areas:

Infection

MPI8 (TG0205221) is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 MPro and host cell cysteine protease L (cathepsin L). MPI8 can be used in clinical studies of COVID-19 .

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MPI8 TFA

Cat. No.: HY-158763A

Synonyms: TG0205221 TFA

Target:

SARS-CoV Cathepsin Virus Protease

Research Areas:

Infection

MPI8 (TG0205221) TFA is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 TFA exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 MPro and host cell cysteine protease L (cathepsin L). MPI8 TFA can be used in clinical studies of COVID-19 .

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AS-0017445

Cat. No.: HY-172553

CAS No.: 3090710-48-5

Target:

Virus Protease SARS-CoV

Research Areas:

Infection

AS-0017445 is an inhibitor targeting the main protease of both the current coronavirus and the virus that caused the Middle East Respiratory Syndrome (MERS) outbreak. AS-0017445 inhibits the viral protein processing in host cells and thus prevents viral replication .

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Simeprevir sodium

Cat. No.: HY-10241A

CAS No.: 1241946-89-3

Synonyms: TMC435 sodium; TMC435350 sodium

Target:

HCV HCV Protease SARS-CoV DNA/RNA Synthesis

Research Areas:

Infection

Simeprevir (TMC435; TMC435350) sodium is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir sodium inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir sodium also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir sodium inhibits the main protease (M ^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

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Apilimod hydrochloride

Cat. No.: HY-14644B

CAS No.: 870087-37-9

Synonyms: STA 5326 hydrochloride; LAM-002A free base hydrochloride; AIT-101 hydrochloride

Target:

NOD-like Receptor (NLR)

Research Areas:

Infection Inflammation/Immunology

Apilimod (STA 5326) hydrochloride is a PIKFYVE kinase inhibitor that promotes NLRP3 inflammatory vesicle activation and IL-1β secretion. Apilimod hydrochloride has been shown to inhibit host cell proteases, which may prevent viral invasion but also block antiviral immune responses, potentially exacerbating immunosuppression in COVID-19.

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Simeprevir-13C,d3

Cat. No.: HY-10241S

Synonyms: TMC435-¹³C,d₃; TMC435350-¹³C,d₃

Simeprevir- ¹³C,d₃ is the ¹³C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

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2Abz-SLGRKIQIK(Dnp)-NH2

Cat. No.: HY-P5528

Target:

Inhibitory Antibodies

Research Areas:

Others

2Abz-SLGRKIQIK(Dnp)-NH2 is a biological active peptide. (This peptide is a second complement component (C2), the physiological substrate for the proenzyme Cls, first complement component. The complement system is a central component of host defense but can also contribute to the inflammation seen in pathological conditions. The C1s protease of the C1 complex initiates the host defense pathway. This peptide employs 2Abz/Dnp FRET pair for quantitation of complement enzyme activity.)

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Dabcyl-LNKRLLHETQ-Edans

Cat. No.: HY-P5344

Synonyms: Fluorigenic PEXEL peptide

Target:

Parasite

Research Areas:

Others

Dabcyl-LNKRLLHETQ-Edans (Fluorigenic PEXEL peptide) is a biological active peptide. (This FRET substrate peptide for Plasmepsin V (PMV) is derived from the conserved Plasmodium Export Element (PEXEL) motif of Histidine-Rich Protein II (HRPII). PMV is an ER aspartic protease that recognizes and cleaves the RXL sequence within the PEXEL motif of proteins exported by human malaria parasite Plasmodium falciparum, allowing them to translocate into host erythrocytes.)

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