27

Donepezil

27 Publications Verification

Cat. No.: HY-14566

CAS No.: 120014-06-4

Purity: 99.82%

Synonyms: E2020 free base

Target:

Cholinesterase (ChE)

Research Areas:

Neurological Disease Cancer

Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

16

Galanthamine hydrobromide

16 Cited Publications

Cat. No.: HY-A0009

CAS No.: 1953-04-4

Synonyms: Galantamine hydrobromide

Category:

Alkaloids Other Alkaloids Amaryllidaceae Extract Plants

Target:

Cholinesterase (ChE) nAChR

Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC₅₀ of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α₃β₄, α₄β₂, α₆β₄ nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Chlorpyrifos

2 Cited Publications

Cat. No.: HY-B0815

CAS No.: 2921-88-2

Target:

Environmental Pollutants Cholinesterase (ChE)

Research Areas:

Neurological Disease

Chlorpyrifos is a neurotoxic insecticide that belongs to the class of thionite esters. Chlorpyrifos is also a AChE inhibitor that affects neurological function in insects, humans and other animals. Chlorpyrifos interferes with cell replication and differentiation, ultimately altering synaptic transmission in neurons .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Diazinon

2 Cited Publications

Cat. No.: HY-B1113

CAS No.: 333-41-5

Synonyms: Dimpylate

Target:

Environmental Pollutants Parasite

Research Areas:

Infection

Diazinon is an orally active, irreversible AChE inhibitor and insecticide that can be absorbed through the digestive system, skin or respiratory tract. Diazinon inhibits AChE, leading to accumulation of acetylcholine, which in turn overstimulates ACh receptors and affects the nervous system. Diazinon also produces reactive oxygen species (ROS)， which induce oxidative stress in various tissues. Diazinon is mainly used in the agricultural field as an insecticide and may have potential effects on human and animal health .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

PCS1055 dihydrochloride

2 Cited Publications

Cat. No.: HY-122203

CAS No.: 361979-40-0

Purity: 98.88%

Target:

mAChR Cholinesterase (ChE)

Research Areas:

Neurological Disease

PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC₅₀ of 18.1 nM and a K_d of 5.72 nM. PCS1055 dihydrochloride inhibits radioligand [ ³H]-NMS binding to the M4 receptor with a K_i of 6.5 nM. PCS1055 dihydrochloride exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. PCS1055 dihydrochloride is also a potent AChE inhibitor with IC₅₀ s of 22 nM and 120 nM for electric eel and human AChE, respectively .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

PCS1055

2 Cited Publications

Cat. No.: HY-122203A

CAS No.: 357173-55-8

Purity: 98.02%

Target:

mAChR Cholinesterase (ChE)

Research Areas:

Neurological Disease

PCS1055 is a selective and competitive antagonist for muscarinic M4 receptor with an IC₅₀ of 18.1 nM and a K_d of 5.72 nM. PCS1055 inhibits radioligand [ ³H]-NMS binding to the M4 receptor with a K_i of 6.5 nM. PCS1055 is also an inhibitor for AChE with IC₅₀ of 22 nM and 120 nM for electric eel and human AChE, respectively .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

3-Isomangostin

1 Cited Publications

Cat. No.: HY-N6845

CAS No.: 19275-46-8

Category:

Xanthones Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer

Target:

DNA/RNA Synthesis Cholinesterase (ChE) CDK Aldose Reductase Bacterial

3-Isomangostin is a flavonoid compound that acts as an inhibitor of MTH1 and acetylcholinesterase, with an IC₅₀ of 52 nM against MTH1 and IC₅₀ values of 5.75 μM and 12.96 μM against AChE and BChE, respectively. 3-Isomangostin also inhibits human aldose reductase and CDK4/Cyclin D1 with IC₅₀ values of 3.48 μM and 15.6 μM, respectively. 3-Isomangostin inhibits polyol pathway flux, competes with 8-oxo-dGTP for binding to the MTH1 active site through hydrogen bonding and hydrophobic xanthone interactions, blocks cell cycle progression, reduces cancer cell viability, and exhibits growth inhibitory effects against both normal and penicillin-resistant Staphylococcus aureus. 3-Isomangostin is used in research on Alzheimer's disease, diabetic complications, Staphylococcus aureus infections, and colon cancer .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Edrophonium chloride

Cat. No.: HY-B0882

CAS No.: 116-38-1

Target:

Cholinesterase (ChE)

Research Areas:

Neurological Disease Inflammation/Immunology

Edrophonium chloride is a short-acting acetylcholinesterase (AChE) inhibitor. Edrophonium chloride has K_i values of 0.2, 0.2, and 0.4 μM and IC₅₀ values of 0.2, 0.05, and 0.5 μM for AChE in human erythrocytes, purified calf forebrain, and purified octopus brain, respectively. Edrophonium chloride can be used to detect early digitalis toxicity and in the study of myasthenia gravis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Chlorpyrifos-d10

Cat. No.: HY-B0815S

CAS No.: 285138-81-0

Target:

Cholinesterase (ChE)

Research Areas:

Neurological Disease

Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Ambenonium chloride

Cat. No.: HY-100919

CAS No.: 115-79-7

Purity: 96.18%

Synonyms: WIN 8077 chloride

Target:

Cholinesterase (ChE)

Research Areas:

Others

Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium chloride inhibits human AChE with an IC₅₀ value of 0.7 nM (hAChE) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Methylene Violet 3RAX

Cat. No.: HY-W130236

CAS No.: 4569-86-2

Target:

Cholinesterase (ChE)

Research Areas:

Cancer

Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an K_is of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy) .

Compare

loading...