493 Results for "

human B cells

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GSK-J4 hydrochloride

67 Publications Verification

Cat. No.: HY-15648F

CAS No.: 1797983-09-5

Purity: 99.01%

Target:

Histone Demethylase

Research Areas:

Cancer

GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC₅₀s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC₅₀ of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 .

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GSK-J4

67 Publications Verification

Cat. No.: HY-15648B

CAS No.: 1373423-53-0

Purity: 99.64%

Target:

Histone Demethylase Apoptosis

Research Areas:

Cancer

GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC₅₀s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC₅₀ of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1 . GSK-J4 induces endoplasmic reticulum stress-related apoptosis .

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Biotin

30 Cited Publications

Cat. No.: HY-B0511

CAS No.: 58-85-5

Synonyms: Vitamin B7; Vitamin H; D-Biotin

Category:

Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Metabolic Disease Plants Other Families Extract Endogenous metabolite Disease Research Fields

Target:

Environmental Pollutants Endogenous Metabolite

Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

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Niacin

13 Cited Publications

Cat. No.: HY-B0143

CAS No.: 59-67-6

Synonyms: Nicotinic acid; Vitamin B3

Category:

Microorganisms Ketones, Aldehydes, Acids Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite MOFs

Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases .

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Niacin hydrochloride

13 Cited Publications

Cat. No.: HY-B0143A

CAS No.: 636-79-3

Synonyms: Nicotinic acid hydrochloride; Vitamin B3 hydrochloride

Category:

Alkaloids Ketones, Aldehydes, Acids Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:

Endogenous Metabolite Apoptosis

Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases .

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Medroxyprogesterone

11 Cited Publications

Cat. No.: HY-B0648

CAS No.: 520-85-4

Synonyms: 17α-Hydroxy-6α-methylprogesterone; U8840

Target:

Progesterone Receptor

Research Areas:

Endocrinology Cancer

Medroxyprogesterone (17α-Hydroxy-6α-methylprogesterone) is a synthetic human variant of progesterone that is a progesterone receptor agonist with oral activity. Medroxyprogesterone can induce cell proliferation through the PI3K/Akt signaling pathway. Medroxyprogesterone has an inhibitory effect on atherosclerosis in mice. The progesterone agonist activity of Medroxyprogesterone is less effective than Medroxyprogesterone acetate (HY-B0469) .

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NSC 95397

9 Cited Publications

Cat. No.: HY-108543

CAS No.: 93718-83-3

Purity: ≥99.0%

Target:

Phosphatase Apoptosis

Research Areas:

Cancer

NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor (K_i=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC₅₀=22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B)) . NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway .

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GNE-140 racemate

9 Cited Publications

Cat. No.: HY-100742

CAS No.: 1802977-61-2

Purity: 99.38%

Target:

Lactate Dehydrogenase p38 MAPK EGFR Akt Caspase Reactive Oxygen Species (ROS)

Research Areas:

Inflammation/Immunology Cancer

GNE-140 racemate is a racemic mixture of (R)-GNE-140 (HY-100742A) and (S)-GNE-140 (HY-100742B), and also a tautomer of GNE-140 (HY-118241). GNE-140 racemate is an orally active lactate dehydrogenase inhibitor, with an IC₅₀ of 3 nM against human LDHA and an IC₅₀ of 5 nM against LDHB. GNE-140 racemate reduces the phosphorylation level and total protein expression of p38 MAPK, and inhibits EGF-induced AKT phosphorylation. GNE-140 racemate decreases lactate production, regulates glycolysis, the pentose phosphate pathway and nucleotide biosynthesis, increases extracellular pH, inhibits cell proliferation, migration and invasion, and induces caspase-3 activation and ROS accumulation. GNE-140 racemate can be used in research related to breast cancer, cystic fibrosis and pancreatic cancer .

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Cyclopiazonic acid

7 Cited Publications

Cat. No.: HY-N6771

CAS No.: 18172-33-3

Category:

Alkaloids Microorganisms Pyrrole Alkaloids Other Diseases Disease Research Fields Indole Alkaloids

Target:

Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV

Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B ^[1][4][5].

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Isobavachin

6 Cited Publications

Cat. No.: HY-N0762

CAS No.: 31524-62-6

Category:

Flavonoids Neurological Disease Flavonones Phenols Polyphenols 500 - Internal Server Error | MedChemExpress

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