30 Results for "

human BChE

" in MedChemExpress (MCE) Product Catalog:
Products (30)

30 Results for "human BChE" in MCE Product Catalog:

1
Drofenine hydrochloride
Drofenine hydrochloride
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1 Cited Publications
Cat. No.: HY-B1239
CAS No.: 548-66-3
Synonyms: Hexahydroadiphenine hydrochloride
Target:  

Cholinesterase (ChE) Potassium Channel Amyloid-β TRP Channel Tau Protein NOD-like Receptor (NLR) JNK NF-κB IKK

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology

Drofenine (Cycloadiphene; Hexahydroadiphenine) hydrochloride is an brain-penetrant antispasmodic agent. Drofenine hydrochloride is a Kv2.1 channel inhibitor with human IC50 of 9.53 μM. Drofenine hydrochloride is a butyrylcholinesterase (BChE) inhibitor with Ki of 0.003 mM, and is a TRPV3 activator. Drofenine hydrochloride blocks Kv2.1-dependent potassium efflux, inhibits Kv2.1/JNK/NF-κB and IkBa/NF-kB signaling, suppresses Kv2.1 mRNA/protein expression. Drofenine suppresses oligomeric Aβ-induced microglial NLRP3 inflammasome activation and neuronal Tau hyperphosphorylation, improves cognitive impairment, promotes neurite outgrowth. Drofenine hydrochloride induces calcium influx in keratinocytes and exert cytotoxicity against keratinocytes. Drofenine hydrochloride ameliorates diabetic peripheral neuropathy -like pathology. Drofenine hydrochloride can be used for the researches of Alzheimer's disease, diabetic peripheral neuropathy and smooth muscle spasm .
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1
N-Nornuciferine
N-Nornuciferine
0 Images
1 Cited Publications
Cat. No.: HY-N2129
CAS No.: 4846-19-9
Category:  

Cardiovascular Disease Alkaloids Metabolic Disease Nymphaeaceae Extract 500 - Internal Server Error | MedChemExpress

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