Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
36 Results for "
human CYP 2C9
" in MedChemExpress (MCE) Product Catalog:
Products (36)
36 Results for "human CYP 2C9" in MCE Product Catalog:
36
36 Publications Verification
Cat. No.: HY-17356
CAS No.: 49562-28-9
Target:
Research Areas:
Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.
16
14
Research Areas:
Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion .
6
6 Cited Publications
Cat. No.: HY-N0762
CAS No.: 31524-62-6
5
5 Cited Publications
Cat. No.: HY-N0904
CAS No.: 39262-14-1
Synonyms: Ginsenoside compound K; Ginsenoside K
Category:
Triterpenes Plant Terpenoids Panax ginseng C. A. Meyer Extract Disease Research Fields Inflammation/Immunology Araliaceae Extract
Target:
3
Target:
Research Areas:
Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively.
3
3 Cited Publications
Cat. No.: HY-B0153A
CAS No.: 53885-35-1
Target:
Research Areas:
Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively .
1
1 Cited Publications
Target:
Research Areas:
LKY-047, a Decursin derivative, is a potent and selective reversible competitive cytochrome P45022J2 (CYP2J2) inhibitor with an IC50 of 1.7 μM. LKY-047 is inactive against other human P450s, such as CYPs 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A .
Category:
Umbelliferae/Apiaceae Extract Other Monoterpenes Plant Foeniculum vulgare Mill. Extract Terpenoids Other Diseases Disease Research Fields
Target:
Cat. No.: HY-17356S
CAS No.: 1092484-56-4
Target:
Research Areas:
Terizidone is an antibacterial agent. Terizidone acts as a prodrug to release D-cycloserine (HY-B0030), which competitively inhibits alanine racemase and D-alanine:D-alanine ligase, interfering with peptidoglycan synthesis and thereby inhibiting cell wall assembly in Mycobacterium tuberculosis. Terizidone does not significantly inhibit human liver microsomal CYP1A2 or CYP2C9 enzyme activity. Terizidone can be used in research related to tuberculosis .
Cat. No.: HY-100386R
CAS No.: 55142-85-3
Synonyms: PCR 5332 (Standard)
Research Areas:
Ticlopidine (Standard) is the analytical standard of Ticlopidine. This product is intended for research and analytical applications. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively .
Cat. No.: HY-17356R
CAS No.: 49562-28-9
Research Areas:
Fenofibrate (Standard) is the analytical standard of Fenofibrate. This product is intended for research and analytical applications. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.
Cat. No.: HY-N0904R
CAS No.: 39262-14-1
Synonyms: Ginsenoside compound K(Standard); Ginsenoside K (Standard)
Research Areas:
Sulfaphenazole (Standard) is the analytical standard of Sulfaphenazole. This product is intended for research and analytical applications. Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion .
Cat. No.: HY-RS03460
Target:
Research Areas:
CYP2C9 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP2C9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-E72098
Target:
Research Areas:
Human CYP2C9, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, which consists of human cytochrome P450 2C9, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP2C9 is a human cytochrome P450 subtype belonging to the CYP2 family, and also a major metabolic enzyme. It is predominantly expressed in human liver and can metabolize a variety of active compounds .
Cat. No.: HY-17356G
CAS No.: 49562-28-9
Cat. No.: HY-137213
CAS No.: 94061-83-3
Target:
Research Areas:
Fluvastatin lactone is the lactone form of Fluvastatin (HY-14664) detected in human plasma after administration. It competitively or mixed-type inhibits CYP2C9-catalyzed S-Warfarin 7-hydroxylation, and induces myotoxicity in a concentration- and time-dependent manner in rat and primary human skeletal muscle cells, reducing the number of surviving myotubes and causing morphological changes in myotubes. Fluvastatin lactone can be used for studies on myotoxicity and statin-induced myotoxicity .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
