30 Results for "

human CYP2D6

" in MedChemExpress (MCE) Product Catalog:
Products (30)

30 Results for "human CYP2D6" in MCE Product Catalog:

3
Endoxifen (Z-isomer)
Endoxifen (Z-isomer)
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3 Cited Publications
Cat. No.: HY-18719
CAS No.: 112093-28-4
Target:  

PKC Estrogen Receptor/ERR PI3K Akt mTOR Apoptosis Reactive Oxygen Species (ROS)

Research Areas:  

Neurological Disease Cancer

Endoxifen Z-isomer is an orally active selective PKCβ1 inhibitor with an IC50 of 360 nM against human PKCβ1. Endoxifen Z-isomer also acts as an estrogen receptor modulator and antiestrogen. Endoxifen Z-isomer binds to and blocks ERα, ERβ and PKCβ1, inhibits estrogen and PI3K/AKT/mTORC1 signaling pathways, suppresses the expression of genes associated with cell cycle, cell proliferation and extracellular matrix remodeling, and induces apoptosis, reactive oxygen species (ROS) production and hypoxic features. Endoxifen Z-isomer inhibits tumor growth in breast tumor and glioblastoma models, reduces bone turnover and blood lipid levels, and does not require metabolism via CYP2D6. Endoxifen Z-isomer can be used in research related to ER + breast cancer, invasive breast cancer, glioblastoma multiforme, type I bipolar disorder, desmoid tumor, gynecological malignancies, melanoma and hormone receptor-positive solid tumors .
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Zotiraciclib
Zotiraciclib
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3 Cited Publications
Cat. No.: HY-15163
CAS No.: 1204918-72-8
Synonyms: TG02; SB1317
Target:  

JAK CDK FLT3

Research Areas:  

Cancer

Zotiraciclib (TG02; SB1317) is an orally active JAK2/FLT3/CDK2 inhibitor with IC50 values of 13 nM, 73 nM and 56 nM , respectively. Zotiraciclib inhibits cancer cell proliferation, tumor growth and the activity of CYP2D6. Zotiraciclib exhibits high plasma protein binding rate, Caco-2 permeability and tissue distribution capacity, as well as metabolic stability in human and canine liver microsomes. Zotiraciclib achieves tumor growth inhibition in nude mouse models of colon cancer and lymphoma xenografts. Zotiraciclib can be used for research related to colon cancer, B-cell lymphoma, advanced leukemia, acute leukemia and multiple myeloma .
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3
Endoxifen (Z-isomer hydrochloride)
Endoxifen (Z-isomer hydrochloride)
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3 Cited Publications
Cat. No.: HY-18719A
CAS No.: 1032008-74-4
Target:  

PKC Estrogen Receptor/ERR PI3K Akt mTOR Apoptosis Reactive Oxygen Species (ROS)

Endoxifen Z-isomer hydrochloride is an orally active selective PKCβ1 inhibitor with an IC50 of 360 nM against human PKCβ1. It also acts as an estrogen receptor modulator and antiestrogen. Endoxifen Z-isomer hydrochloride binds to and blocks ERα, ERβ and PKCβ1, inhibits estrogen and PI3K/AKT/mTORC1 signaling pathways, suppresses the expression of genes associated with cell cycle, cell proliferation and extracellular matrix remodeling, and induces apoptosis, reactive oxygen species (ROS) production and hypoxic features. Endoxifen Z-isomer hydrochloride inhibits tumor growth in breast tumor and glioblastoma models, reduces bone turnover and blood lipid levels, and does not require metabolism via CYP2D6. It can be used in research related to ER + breast cancer, invasive breast cancer, glioblastoma multiforme, type I bipolar disorder, desmoid tumor, gynecological malignancies, melanoma and hormone receptor-positive solid tumors .
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1
N-Nornuciferine
N-Nornuciferine
0 Images
1 Cited Publications
Cat. No.: HY-N2129
CAS No.: 4846-19-9
Category:  

Cardiovascular Disease Alkaloids Metabolic Disease Nymphaeaceae Extract 500 - Internal Server Error | MedChemExpress

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