30 Results for "

human DPP-IV

" in MedChemExpress (MCE) Product Catalog:
Products (30)

30 Results for "human DPP-IV" in MCE Product Catalog:

5
Vildagliptin
Vildagliptin
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5 Cited Publications
Cat. No.: HY-14291
CAS No.: 274901-16-5
Purity:  99.93%
Synonyms: LAF237; NVP-LAF 237
Target:  

Dipeptidyl Peptidase Ferroptosis Apoptosis

Research Areas:  

Metabolic Disease Cancer

Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
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5
CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293)
CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293)
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5 Cited Publications
Cat. No.: HY-P72975
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: DPP4; DPP IV; Prev. ADCP2; TP103; Prev. CD26; Post-Proline Dipeptidyl Aminopeptidase IV; Adenosine Deaminase Complexing Protein 2; Xaa-Pro-Dipeptidylaminopeptidase; T-Cell ActIVation Antigen CD26; Gly-Pro Naphthylamidase; Dipeptidyl Peptidase IV; Dipeptid
Species:  
Human
Source:  
HEK293
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2
FAP Protein, Human (HEK293, N-His)
FAP Protein, Human (HEK293, N-His)
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2 Cited Publications
Cat. No.: HY-P72659A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FAP; Prolyl Endopeptidase FAP; Fibroblast ActIVation Protein Alpha; Dipeptidyl Peptidase FAP; Seprase; FAPalpha; DPPIV; SIMP; 170 KDa Melanoma Membrane-Bound Gelatinase; CDNA FLJ60298, Highly Similar To Seprase; Gelatine Degradation Protease FAP; Fibroblast ActIVation Protein, Alpha; Integral Membrane Serine Protease; Serine Integral Membrane Protease; Post-Proline Cleaving Enzyme; FAPA; Surface-Expressed Protease
Species:  
Human
Source:  
HEK293
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1
CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, His)
CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, His)
0 Images
1 Cited Publications
Cat. No.: HY-P70017
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DPP4; DPP IV; Prev. ADCP2; TP103; Prev. CD26; Post-Proline Dipeptidyl Aminopeptidase IV; Adenosine Deaminase Complexing Protein 2; Xaa-Pro-Dipeptidylaminopeptidase; T-Cell ActIVation Antigen CD26; Gly-Pro Naphthylamidase; Dipeptidyl Peptidase IV; Dipeptid
Species:  
Human
Source:  
HEK293
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NVP-DPP728
NVP-DPP728
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Cat. No.: HY-14292
CAS No.: 247016-69-9
Target:  

Dipeptidyl Peptidase

Research Areas:  

Metabolic Disease

NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a Ki of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes .
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HAEGT
HAEGT
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Cat. No.: HY-P1230
CAS No.: 852155-81-8
Target:  

Dipeptidyl Peptidase GLP Receptor

Research Areas:  

Metabolic Disease

HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr. HAEGT acts as a competitive substrate for probing prime substrate binding sites of human dipeptidyl peptidase-IV (DPP-IV) 1, in which the N-terminal His-Ala is catalyzed cleavage by DPP-IV. HAEGT can be used in the research of diabetes, obesity .
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Vildagliptin dihydrate
Vildagliptin dihydrate
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Cat. No.: HY-14291A
CAS No.: 2133364-01-7
Synonyms: LAF237 dihydrate; NVP-LAF 237 dihydrate
Target:  

Dipeptidyl Peptidase Ferroptosis Apoptosis

Research Areas:  

Metabolic Disease Cancer

Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity .
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Vildagliptin-d7
Vildagliptin-d7
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Cat. No.: HY-14291S1
CAS No.: 1133208-42-0
Synonyms: LAF237-d7; NVP-LAF 237-d7
Vildagliptin-d7 is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
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Vildagliptin-d3
Vildagliptin-d3
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Cat. No.: HY-14291S
CAS No.: 1217546-82-1
Synonyms: LAF237-d3; NVP-LAF 237-d3
Vildagliptin-d3 is the deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
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Vildagliptin (Standard)
Vildagliptin (Standard)
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Cat. No.: HY-14291R
CAS No.: 274901-16-5
Synonyms: LAF237 (Standard); NVP-LAF 237 (Standard)
Target:  

Reference Standards Dipeptidyl Peptidase Ferroptosis Apoptosis

Research Areas:  

Metabolic Disease

Vildagliptin (Standard) is the analytical standard of Vildagliptin. This product is intended for research and analytical applications. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
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Vildagliptin-13C5,15N
Vildagliptin-13C5,15N
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Cat. No.: HY-14291S2
CAS No.: 1044741-01-6
Synonyms: LAF237-13C5,15N; NVP-LAF 237-13C5,15N
Vildagliptin- 13C5, 15N (LAF237- 13C5, 15N; NVP-LAF 237- 13C5, 15N) is a 13C- and 15N-labeled Vildagliptin (HY-14291). Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
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RBx-0597
RBx-0597
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Cat. No.: HY-169724
CAS No.: 929105-33-9
Target:  

Dipeptidyl Peptidase

Research Areas:  

Metabolic Disease

RBx-0597 is a potent and selective DPP-IV inhibitor, demonstrating IC50 values of 32, 31, and 39 nM against human, mouse, and rat plasma DPP-IV, respectively. RBx-0597 shows potential for type 2 diabetes research .
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TS-021
TS-021
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Cat. No.: HY-U00346A
CAS No.: 667865-69-2
Target:  

Dipeptidyl Peptidase

Research Areas:  

Metabolic Disease

TS-021 is a selective，orally active，reversible and long-acting DPP-IV inhibitor，and exhibits significant inhibition selectivity against DPP-8 (> 600 fold)，DPP-9 (> 1200 fold) and other peptidases (> 15,000 fold). TS-021 inhibits DPP-IV activity in human plasma with an IC50 value of 5.34 nM. TS-021 has long-term persistent plasma drug concentration and potent antihyperglycemic activity，and increases in the active form of GLP-1 .
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AMG-222
AMG-222
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Cat. No.: HY-111150
CAS No.: 913978-37-7
Target:  

Dipeptidyl Peptidase

Research Areas:  

Metabolic Disease

AMG-222 is a dipeptidyl peptidase IV (DPP-IV) inhibitor that exerts its inhibitory effect by tightly and reversibly binding to DPPIV. AMG 222 binds to human plasma proteins in a saturable and concentration-dependent manner, with a binding rate of 80.8% at 1 nM, while the binding rate decreases to 29.4% at concentrations above 100 nM. AMG-222 can be used in research related to diabetes .
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(2R)-Vildagliptin
(2R)-Vildagliptin
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Cat. No.: HY-14291B
CAS No.: 1036959-27-9
Synonyms: (2R)-LAF237; (2R)-NVP-LAF 237
Target:  

Dipeptidyl Peptidase

Research Areas:  

Metabolic Disease

(2R)-Vildagliptin is the isomer of Vildagliptin (HY-14291), and can be used as an experimental control. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
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Vildagliptin-d6
Vildagliptin-d6
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Cat. No.: HY-14291S5
Synonyms: LAF237-d6 ; NVP-LAF 237-d6
Vildagliptin-d6 (LAF237-d6 ) is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
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Carmegliptin
Carmegliptin
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Cat. No.: HY-10289
CAS No.: 813452-18-5
Synonyms: RO-4876904; R-1579
Target:  

Dipeptidyl Peptidase GLP Receptor P-glycoprotein

Research Areas:  

Metabolic Disease

Carmegliptin (RO-4876904) is an orally active and potent DPP IV inhibitor with a human DPP IV IC50 of 6.8 nM. Carmegliptin binds to the S1 pocket of DPP IV, blocks the degradation of GLP 1, potentiates endogenous GLP 1, increases plasma insulin levels, alleviates hyperglycemia, improves glucose tolerance. Carmegliptin acts as a substrate for human P glycoprotein without inhibiting the transporter, shows low in vitro cell permeability. Carmegliptin can be used for the research of type 2 diabetes, non insulin dependent diabetes mellitus .
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Garvagliptin
Garvagliptin
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Cat. No.: HY-109060
CAS No.: 1601479-87-1
Synonyms: ZYDPLA1
Target:  

Dipeptidyl Peptidase

Research Areas:  

Metabolic Disease

Garvagliptin (ZYDPLA1) is an orally active, competitive and long acting DPP4 Inhibitor, with an IC50 of 2.99 nM against human recombinant DPP IV. Garvagliptin (ZYDPLA1) exhibits antihyperglycemic effect .
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Carmegliptin hydrochloride
Carmegliptin hydrochloride
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Cat. No.: HY-10289A
CAS No.: 813452-14-1
Synonyms: RO-4876904 hydrochloride; R-1579 hydrochloride
Target:  

Dipeptidyl Peptidase GLP Receptor P-glycoprotein

Research Areas:  

Metabolic Disease

Carmegliptin hydrochloride (RO-4876904 hydrochloride) is an orally active and potent DPP‑IV inhibitor with a human DPP‑IV IC50 of 6.8 nM. Carmegliptin hydrochloride binds to the S1 pocket of DPP‑IV, blocks the degradation of GLP‑1, potentiates endogenous GLP‑1, increases plasma insulin levels, alleviates hyperglycemia, improves glucose tolerance. Carmegliptin hydrochloride acts as a substrate for human P‑glycoprotein without inhibiting the transporter, shows low in vitro cell permeability. Carmegliptin hydrochloride can be used for the research of type 2 diabetes, non‑insulin‑dependent diabetes mellitus .
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Cyclocarin A
Cyclocarin A
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Cat. No.: HY-N17777
CAS No.: 1403937-45-0
Category:  

Triterpenes Terpenoids Juglandaceae Extract 500 - Internal Server Error | MedChemExpress

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