6

NXT629

6 Publications Verification

Cat. No.: HY-114263

CAS No.: 1454925-59-7

Purity: 99.07%

Target:

PPAR

Research Areas:

Cancer

NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC₅₀ of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC₅₀s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively . NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models .

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4

Prinaberel

4 Cited Publications

Cat. No.: HY-14933

CAS No.: 524684-52-4

Purity: 98.05%

Synonyms: ERB-041

Target:

Estrogen Receptor/ERR Wnt Apoptosis

Research Areas:

Cancer

Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC₅₀s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis .

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3

Endoxifen (Z-isomer)

3 Cited Publications

Cat. No.: HY-18719

CAS No.: 112093-28-4

Target:

PKC Estrogen Receptor/ERR PI3K Akt mTOR Apoptosis Reactive Oxygen Species (ROS)

Research Areas:

Neurological Disease Cancer

Endoxifen Z-isomer is an orally active selective PKCβ1 inhibitor with an IC₅₀ of 360 nM against human PKCβ1. Endoxifen Z-isomer also acts as an estrogen receptor modulator and antiestrogen. Endoxifen Z-isomer binds to and blocks ERα, ERβ and PKCβ1, inhibits estrogen and PI3K/AKT/mTORC1 signaling pathways, suppresses the expression of genes associated with cell cycle, cell proliferation and extracellular matrix remodeling, and induces apoptosis, reactive oxygen species (ROS) production and hypoxic features. Endoxifen Z-isomer inhibits tumor growth in breast tumor and glioblastoma models, reduces bone turnover and blood lipid levels, and does not require metabolism via CYP2D6. Endoxifen Z-isomer can be used in research related to ER ⁺ breast cancer, invasive breast cancer, glioblastoma multiforme, type I bipolar disorder, desmoid tumor, gynecological malignancies, melanoma and hormone receptor-positive solid tumors .

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3

Endoxifen (Z-isomer hydrochloride)

3 Cited Publications

Cat. No.: HY-18719A

CAS No.: 1032008-74-4

Target:

PKC Estrogen Receptor/ERR PI3K Akt mTOR Apoptosis Reactive Oxygen Species (ROS)

Endoxifen Z-isomer hydrochloride is an orally active selective PKCβ1 inhibitor with an IC₅₀ of 360 nM against human PKCβ1. It also acts as an estrogen receptor modulator and antiestrogen. Endoxifen Z-isomer hydrochloride binds to and blocks ERα, ERβ and PKCβ1, inhibits estrogen and PI3K/AKT/mTORC1 signaling pathways, suppresses the expression of genes associated with cell cycle, cell proliferation and extracellular matrix remodeling, and induces apoptosis, reactive oxygen species (ROS) production and hypoxic features. Endoxifen Z-isomer hydrochloride inhibits tumor growth in breast tumor and glioblastoma models, reduces bone turnover and blood lipid levels, and does not require metabolism via CYP2D6. It can be used in research related to ER ⁺ breast cancer, invasive breast cancer, glioblastoma multiforme, type I bipolar disorder, desmoid tumor, gynecological malignancies, melanoma and hormone receptor-positive solid tumors .

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3

Epiregulin Protein, Human

3 Cited Publications

Cat. No.: HY-P7011

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: EREG; AltERnative Protein EREG; Epiregulin; EPR; ER; Ep; Proepiregulin

Species:

Human

Source:

E. coli

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2

ML390

2 Cited Publications

Cat. No.: HY-100688

CAS No.: 2029049-79-2

Purity: 99.72%

Target:

Dihydroorotate Dehydrogenase

Research Areas:

Cancer

ML390 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor. ML390 is an inducer of myeloid differentiation and causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) acute myeloid leukemia (AML) models .

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1

ER-27319

1 Cited Publications

Cat. No.: HY-138961

CAS No.: 201010-95-9

Purity: 98.66%

Target:

Syk

Research Areas:

Inflammation/Immunology

ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases .

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1

ER-27319 maleate

1 Cited Publications

Cat. No.: HY-108489

CAS No.: 1204480-26-1

Purity: ≥99.4%

Target:

Syk

Research Areas:

Inflammation/Immunology

ER-27319 (maleate), an acridone derivative, is a potent and selective SKY inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 (maleate) inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases ^[1] ^[2].

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1

Epiregulin Protein, Human (HEK293, Fc)

1 Cited Publications

Cat. No.: HY-P73031

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: EREG; AltERnative Protein EREG; Epiregulin; EPR; ER; Ep; Proepiregulin

Species:

Human

Source:

HEK293

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1

ER alpha/ESR1 Protein, Human (His)

1 Cited Publications

Cat. No.: HY-P70248

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: ESR1; Estrogen Receptor Alpha Delta 4*,5,6,7*/654 Isoform; Prev. ESR; Estrogen Receptor Alpha 3*,4,5,6,7,8*/1032 Isoform; ER-Alpha; Estrogen Receptor Alpha 3*,4,5,6,7,8*/1068 Isoform; ER; Estrogen Receptor Alpha 3*,4,5,6,7,8*/984 Isoform; Nuclear Receptor Subfamily 3 Group A MembER 1; Hippocampal Estrogen Receptor Alpha Isoform TADDI; Estradiol Receptor; Estrogen Receptor Alpha 2*,3,4,5,6,7*,8* Isoform; NR3A1; Estrogen Receptor Alpha 3*,4,5,6,7*/765 Isoform; Estrogen Receptor; Estrogen Receptor Alpha 3*,4,5,6,7*/822 Isoform; ERa; Estrogen Receptor Alpha Delta 3*4,5*,7 Isoform; Oestrogen Receptor Alpha; Estrogen Receptor Alpha Delta 4,5,6,7 Isoform; Estrogen Receptor Alpha; Estrogen Receptor Alpha Delta 3*4*,7 Isoform; E2 Receptor Alpha; Estrogen Receptor Alpha E1-N2-E2-1-2 Variant; Estrogen Receptor Alpha Delta 2*,3,4,5,6,7*/834 Hypothalamic Isoform; Estrogen Receptor Alpha Delta 4,5,7 Isoform; Estrogen Receptor Alpha Delta 3*,4,5,6,7*/775 Hypothalamic Isoform; Estrogen Receptor Alpha Delta 4 +49 Isoform; Estrogen Receptor Alpha Delta 1*,2,3*/663 Choroid Plexus Isoform; Estrogen Receptor Alpha E1-N1-E2-1 Variant; Estrogen Receptor Alpha Delta 4,7*,8*/581 Hypothalamic Isoform; Estrogen Receptor Alpha E1-N2-E2-2 Variant; Estrogen Receptor Alpha Delta 4*,5,6*/481 Hypothalamic Isoform; Estrogen Receptor Alpha Delta 6,7 Isoform; Estrogen Receptor Alpha Delta 3*,4,5,6,7*, 8*/912 Isoform; Estrogen Receptor Alpha E1-E2-1-2 Variant; Estrogen Receptor Alpha Delta 3*,4,5,6,7*,8*/941 Isoform; Estrogen Receptor Alpha E1-E2-2 Variant; Estrogen Receptor Alpha Delta 3*,4,5,6,7,8*/1029 Isoform; Estrogen Receptor Alpha Splice Variant; Estrogen Receptor Alpha Delta 3*,4,5,6,7*/819-2 Isoform; Estrogen Receptor Alpha E1-1-2 Variant; Estrogen Receptor Alpha Delta 3*,4,5,6,7,8*/969 Isoform; Estrogen Receptor Alpha E1-N2-E2-1-2; Estrogen Receptor Alpha Delta 3*,4,5,6,7,8*/984 Isoform; Estrogen Receptor Alpha E1-2 Variant; Estrogen Receptor Alpha Delta 2*,3,4,5,6,7*/963 Isoform; Estrogen Receptor Alpha E1-E2-1-2; Estrogen Receptor Alpha SupERior Frontal Gyrus Isoform; Estrogen Nuclear Receptor Alpha; Estrogen Receptor Alpha Delta 4*,5,6,7,8*/918 Isoform; Estrogen Receptor Protein; Estrogen Receptor Alpha Delta 4*,5,6,7,8*/885 Isoform; AltERnative Protein ESR1; Estrogen Receptor Alpha Delta 4*,5,6,7,8*/901 Isoform; ESTRR; Estrogen Receptor Alpha Delta 4*,5,6,7*/633 Isoform; ESRA; Estrogen Receptor 1; Estrogen Receptor Alpha Delta 2*,3,4,5,6,7 Isoform

Species:

Human

Source:

E. coli

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