63

63 Publications Verification

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IL6; Hybridoma Growth Factor; Prev. IFNB2; IFN-Beta-2; IL-6; BSF-2; Interleukin-6; CDF; BSF2; Interleukin 6 (Interferon, Beta 2); HGF; B-Cell Differentiation Factor; HSF; Truncated Interleukin 6; B-Cell Stimulatory Factor 2; Interferon, Beta 2; CTL Differ

Species:

Human

Source:

E. coli

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51

Tocilizumab

51 Cited Publications

Cat. No.: HY-P9917

CAS No.: 375823-41-9

Synonyms: Anti-human IL6R, humanized Antibody; RG-1569; rhPM-1

Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis . Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease) .

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10

SC144

10 Cited Publications

Cat. No.: HY-15614

CAS No.: 895158-95-9

Purity: 99.48%

Target:

Interleukin Related Apoptosis

Research Areas:

Cancer

SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells .

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10

SC144 hydrochloride

10 Cited Publications

Cat. No.: HY-15614A

CAS No.: 917497-70-2

Purity: 98.98%

Target:

Interleukin Related Apoptosis

Research Areas:

Cancer

SC144 hydrochloride is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling. SC144 hydrochloride induces apoptosis in human ovarian cancer cells .

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7

JTE-607

7 Cited Publications

Cat. No.: HY-110133

CAS No.: 188791-09-5

Purity: 98.64%

Target:

Interleukin Related

Research Areas:

Inflammation/Immunology

JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC₅₀s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively . Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 .

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5

2'-Fucosyllactose

5 Cited Publications

Cat. No.: HY-N9965

CAS No.: 41263-94-9

Synonyms: 2'-FL

Category:

Infection Polysaccharides Animals Disease Research Fields Inflammation/Immunology Saccharides

Target:

TNF Receptor Interleukin Related

2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines .

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3

Astegolimab

3 Cited Publications

Cat. No.: HY-P99444

CAS No.: 2173054-79-8

Synonyms: MSTT 1041A; RG 6149

Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research .

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2

GMP IL-6 Protein, Human

2 Cited Publications

Cat. No.: HY-P7044G

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IL6; Hybridoma Growth Factor; Prev. IFNB2; IFN-Beta-2; IL-6; BSF-2; Interleukin-6; CDF; BSF2; Interleukin 6 (Interferon, Beta 2); HGF; B-Cell Differentiation Factor; HSF; Truncated Interleukin 6; B-Cell Stimulatory Factor 2; Interferon, Beta 2; CTL Differ

Species:

Human

Source:

E. coli

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2

IL-6 Protein, Human (CHO)

2 Cited Publications

Cat. No.: HY-P7044A

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IL6; Hybridoma Growth Factor; Prev. IFNB2; IFN-Beta-2; IL-6; BSF-2; Interleukin-6; CDF; BSF2; Interleukin 6 (Interferon, Beta 2); HGF; B-Cell Differentiation Factor; HSF; Truncated Interleukin 6; B-Cell Stimulatory Factor 2; Interferon, Beta 2; CTL Differentiation Factor; Interleukin BSF-2; Interleukin 6; Interferon Beta-2

Species:

Human

Source:

CHO

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2

IL-6R alpha Protein, Human (CHO)

2 Cited Publications

Cat. No.: HY-P7223

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IL6R; IL-6R 1; Interleukin 6 Receptor; IL-6RA; Gp80; Interleukin 6 Receptor Subunit Alpha; Interleukin-6 Receptor Subunit Alpha; IL-6R Subunit Alpha; Membrane Glycoprotein 80; IL-6R-Alpha; IL-1Ra; IL-6R-1; IL6RA; IL6QTL; IL-6R; IL6RQ; CD126; HIES5; IL-6 Receptor Subunit Alpha; IL6Q; CD126 Antigen

Species:

Human

Source:

CHO

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1

Teprotumumab

1 Cited Publications

Cat. No.: HY-P99165

CAS No.: 1036734-93-6

Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research .

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