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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
human PDE3
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "human PDE3" in MCE Product Catalog:
Cat. No.: HY-106739
CAS No.: 90697-57-7
Synonyms: NAT 05-239
Target:
Research Areas:
Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP .
Cat. No.: HY-111219
CAS No.: 139145-84-9
Synonyms: NM-702; NT-702
Target:
Research Areas:
Parogrelil (hydrochloride) (NM-702) is a phosphodiesterase inhibitor with activity in inhibiting intermittent claudication. Parogrelil (hydrochloride) selectively inhibits PDE3, inhibits human platelet aggregation in vitro and rat aortic contraction, and improves walking distance and plantar surface temperature in the rat femoral artery ligation model, with better effects than cilostazol.
Cat. No.: HY-RS10216
Target:
Research Areas:
PDE3A Human Pre-designed siRNA Set A contains three designed siRNAs for PDE3A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10219
Target:
Research Areas:
PDE3B Human Pre-designed siRNA Set A contains three designed siRNAs for PDE3B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-105931
CAS No.: 94192-59-3
Synonyms: RS-82856
Target:
Research Areas:
Lixazinone (RS-82856) is a selective inhibitor of cGMP-inhibited phosphodiesterase (PDE3) with an IC50 value of 22 nM. Lixazinone exhibits positive inotropic effects, afterload reduction and antithrombotic properties. Lixazinone increases cyclic adenosine monophosphate (cAMP) levels in human platelets, inhibits thrombin-induced aggregation of human platelets, and blocks the photolabeling of PDE3 active sites by [ 32P]cGMP. Lixazinone can be used in the research of polycystic kidney disease and congestive heart failure .
Cat. No.: HY-113822
CAS No.: 101626-67-9
Synonyms: RS-82856 hydrogensulfate
Target:
Research Areas:
Lixazinone (RS-82856) hydrogensulfate is a selective inhibitor of cGMP-inhibited phosphodiesterase (PDE3) with an IC50 value of 22 nM. Lixazinone hydrogensulfate exhibits positive inotropic effects, afterload reduction and antithrombotic properties. Lixazinone hydrogensulfate increases cyclic adenosine monophosphate (cAMP) levels in human platelets, inhibits thrombin-induced aggregation of human platelets, and blocks the photolabeling of PDE3 active sites by [ 32P]cGMP. Lixazinone hydrogensulfate can be used in the research of polycystic kidney disease and congestive heart failure .
Cat. No.: HY-183463
CAS No.: 182282-60-6
Target:
Research Areas:
D 22888 is an orally active PDE4 inhibitor, with human PDE4 IC50 of 0.153 μM, and selectivity over PDE3 and PDE5. D 22888 elevates intracellular cAMP levels to modulate target cell functions. D 22888 acts as a relaxant of human bronchial ring inherent tone. D 22888 inhibits opsonized zymosan-induced superoxide anion generation by human eosinophils. D 22888 reduces bronchoalveolar lavage eosinophil numbers in allergen-challenged sensitized guinea pigs via single or chronic oral dosing. D 22888 can be used for the research of bronchial asthma .
Cat. No.: HY-P75961
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDE3A; CGMP-Inhibited CAMP Phosphodiesterase; Phosphodiesterase 3A; Phosphodiesterase 3A, CGMP-Inhibited; CGI-PDE; CGI-PDE A; CGMP-Inhibited 3',5'-Cyclic Phosphodiesterase 3A; CAMP Phosphodiesterase, Myocardial CGMP-Inhibited; CGMP-Inhibited 3',5'-Cyclic
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-182271
Research Areas:
GPR61 Inverse agonist 3 is a selective and brain-penetrant GPR61 inverse agonist with human IC50 of 4.0 nM, mouse IC50 of 8.8 nM, human Ki of 0.34 nM, mouse Ki of 1.1 nM. GPR61 Inverse agonist 3 disrupts GPR61-Gαs protein interactions to abolish GPR61 constitutive activity. GPR61 Inverse agonist 3 moderately inhibits GABAA chloride channel and PDE3A1 with IC50 values of 4.6 and 8.9 μM. GPR61 Inverse agonist 3 shows no functional effect on food intake in adult mice co-administered with a pan-CYP inhibitor. GPR61 Inverse agonist 3 can be used for the research of cachexia/sarcopenia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
