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29 Results for "

human PDE4

" in MedChemExpress (MCE) Product Catalog:

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Rolipram

20 Cited Publications

Cat. No.: HY-16900

CAS No.: 61413-54-5

Synonyms: (R,S)-Rolipram; (±)-Rolipram; ZK 62711

Target:

Bacterial HIV Phosphodiesterase (PDE) Epigenetic Reader Domain Amyloid-β

Research Areas:

Infection Neurological Disease Cancer

Rolipram is a PDE4 inhibitor, with blood-brain barrier permeability, that reverses β-amyloid-induced learning and memory impairment in rats. Rolipram elevates intracellular cAMP and clevels and regulates the cAMP/CREB signaling pathway, thereby alleviating neuroinflammation and apoptotic responses. Rolipram promotes neuronal differentiation of human bone marrow mesenchymal stem cells and inhibits Methamphetamine- and morphine-induced hyperlocomotion in mice. Rolipram also reduces the viability of glioblastoma stem-like cells and enhances Bevacizumab (HY-P9906)-induced cell death. Rolipram inhibits the expression of proinflammatory cytokines and enhances central noradrenergic transmission. Rolipram is mainly used in studies related to various central nervous system diseases including Alzheimer's disease, major depressive disorder, glioblastoma multiforme, and multiple sclerosis .

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August 31

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Roflupram

1 Cited Publications

Cat. No.: HY-115383

CAS No.: 1093412-18-0

Purity: 99.45%

Target:

Phosphodiesterase (PDE)

Research Areas:

Neurological Disease Inflammation/Immunology

Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC₅₀ of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors .

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