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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
human PIM-2
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "human PIM-2" in MCE Product Catalog:
Cat. No.: HY-115590
CAS No.: 1902983-63-4
JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 (IC50 = 0.5 nM). JP11646 is freely reversible and ATP non-competitive. JP-11646 results in a decrease of PIM1, 2, and 3 mRNA. JP-11646 can effectively inhibit cell viability in small cell lung cancer (SCLC) and large cell neuroendocrine carcinomas of the lung (LCNEC). JP-11646 can cause a decrease in p-4EBP-1 protein, increasing the cleavage of caspases while decreasing caspase-3. JP-11646 induces apoptosis or necroptosis in cells. JP-11646 leads to reductions in MYC paralogs. JP-11646 can be used for the study of SCLC, LCNEC, human acute leukemia (AML), multiple myeloma (MM), and triple-negative breast cancer (TNBC) .
Cat. No.: HY-RS10550
Target:
Research Areas:
PIM2 Human Pre-designed siRNA Set A contains three designed siRNAs for PIM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-157404
CAS No.: 2918764-16-4
Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive PIM-1 and PIM-2 kinase inhibitor with IC50s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines .
Cat. No.: HY-P701746
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PIM2; PIM-2h; PIM-2 Proto-Oncogene, Serine/Threonine Kinase; Proto-Oncogene PIM-2 (Serine Threonine Kinase); Serine/Threonine-Protein Kinase PIM-2; Non-Specific Serine/Threonine Protein Kinase; PIM-2 Oncogene
Species:
Human
Source:
E. coli
Cat. No.: HY-P701747
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PIM2; PIM-2h; PIM-2 Proto-Oncogene, Serine/Threonine Kinase; Proto-Oncogene PIM-2 (Serine Threonine Kinase); Serine/Threonine-Protein Kinase PIM-2; Non-Specific Serine/Threonine Protein Kinase; PIM-2 Oncogene
Species:
Human
Source:
E. coli
Cat. No.: HY-P706086
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PIM2; PIM-2h; PIM-2 Proto-Oncogene, Serine/Threonine Kinase; Proto-Oncogene PIM-2 (Serine Threonine Kinase); Serine/Threonine-Protein Kinase PIM-2; Non-Specific Serine/Threonine Protein Kinase; PIM-2 Oncogene
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
