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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
431 Results for "
human leukemia
" in MedChemExpress (MCE) Product Catalog:
Products (431)
431 Results for "human leukemia" in MCE Product Catalog:
119
119 Publications Verification
Target:
Research Areas:
S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1 .
26
26 Cited Publications
Synonyms: Astringenin; trans-Piceatannol
Category:
Plant Stilbenes Rheum palmatum L. Extract Disease Research Fields Polygonaceae Extract Cancer
Target:
17
17 Cited Publications
Cat. No.: HY-N6733
CAS No.: 38966-21-1
16
16 Cited Publications
Synonyms: Thioguanine; 2-Amino-6-purinethiol
10
10 Cited Publications
Cat. No.: HY-19619
CAS No.: 200933-14-8
Target:
Research Areas:
m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis .
10
10 Cited Publications
THAL-SNS-032 is a selective CDK9 PROTAC degrader. THAL-SNS-032 recruits CRBN to form a ternary complex with CDK9, thereby triggering ubiquitination and proteasomal degradation of CDK9. THAL-SNS-032 also induces the degradation of CDK1, CDK2 and CDK7. THAL-SNS-032 elevates pH2AX levels, reduces MCL1s expression, and activates caspase-3. THAL-SNS-032 induces cancer cell apoptosis, regulates transcription, and inhibits the replication of human cytomegalovirus (CMV) and SARS-CoV-2. THAL-SNS-032 can be used in research related to breast cancer, leukemia, cytomegalovirus infection and SARS-CoV-2 infection .
8
Target:
Parbendazole (SKF‑29044) is an orally active benzimidazole carbamate compound with multiple biological activities. Parbendazole binds to free tubulin and inhibits microtubule polymerization; it also activates the JNK/c‑Jun signaling axis and upregulates the expression of the downstream axonal repulsion factor Sema3A. Parbendazole upregulates KAL-1 mRNA expression, reduces nerve growth factor levels, and promotes the terminal differentiation of normal human epidermal keratinocytes. Parbendazole induces apoptosis in differentiated acute myeloid leukemia monocytes and exerts antileukemic activity in a mouse xenograft model of acute myeloid leukemia. Parbendazole exhibits broad-spectrum anthelmintic activity against various animal nematodes. Parbendazole is used in research related to acute myeloid leukemia and parasitic infections .
8
8 Cited Publications
Target:
Research Areas:
MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 consists of ligands for Cereblon and MDM2. MD-224 induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells, and achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells. MD-224 has the potential to be a new class of anticancer agent . MD-224 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
5
5 Cited Publications
Cat. No.: HY-P7049
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LIF; Hepatocyte-Stimulating Factor III; LIF Interleukin 6 Family Cytokine; Differentiation-Inducing Factor; HILDA; Melanoma-Derived LPL Inhibitor; leukemia Inhibitory Factor; human Interleukin In DA Cells; CDF; D Factor; DIA; MLPLI; Differentiation Inhibi
Species:
Human
Source:
E. coli
5
5 Cited Publications
Cat. No.: HY-P73276
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: LIF; Hepatocyte-Stimulating Factor III; LIF Interleukin 6 Family Cytokine; Differentiation-Inducing Factor; HILDA; Melanoma-Derived LPL Inhibitor; leukemia Inhibitory Factor; human Interleukin In DA Cells; CDF; D Factor; DIA; MLPLI; Differentiation Inhibi
Species:
Human
Source:
HEK293
5
5 Cited Publications
Cat. No.: HY-P7084
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LIF; Hepatocyte-Stimulating Factor III; LIF Interleukin 6 Family Cytokine; Differentiation-Inducing Factor; HILDA; Melanoma-Derived LPL Inhibitor; leukemia Inhibitory Factor; human Interleukin In DA Cells; CDF; D Factor; DIA; MLPLI; Differentiation Inhibi
Species:
Mouse
Source:
E. coli
4
Category:
Plant Terpenoids Salvia sclarea Extract Diterpenoids Perilla frutescens (L.) Britt. Extract Disease Research Fields Cancer Labiatae Extract
Target:
4
Research Areas:
Farudodstat (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. Farudodstat inhibits protein synthesis via activation of AP-1 transcription factors. Farudodstat induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice .
4
4 Cited Publications
Cat. No.: HY-N2435
CAS No.: 36700-45-5
3
Zotiraciclib (TG02; SB1317) is an orally active JAK2/FLT3/CDK2 inhibitor with IC50 values of 13 nM, 73 nM and 56 nM , respectively. Zotiraciclib inhibits cancer cell proliferation, tumor growth and the activity of CYP2D6. Zotiraciclib exhibits high plasma protein binding rate, Caco-2 permeability and tissue distribution capacity, as well as metabolic stability in human and canine liver microsomes. Zotiraciclib achieves tumor growth inhibition in nude mouse models of colon cancer and lymphoma xenografts. Zotiraciclib can be used for research related to colon cancer, B-cell lymphoma, advanced leukemia, acute leukemia and multiple myeloma .
3
Category:
Triterpenes Plant Terpenoids Burseraceae Extract Other Families Extract Disease Research Fields Cancer Boswellia serrata Extract
Target:
3
3 Cited Publications
Cat. No.: HY-P71140
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: S100A4; Fibroblast-Specific Protein-1; Prev. CAPL; Murine Placental Homolog; Prev. MTS1; Protein S100-A4; PEL98; Metastasin 1; P9KA; Protein Mts1; 18A2; Calvasculin; FSP1; leukemia Multidrug Resistance Associated Protein; 42A; Malignant Transformation Sup
Species:
Human
Source:
E. coli
2
2
2 Cited Publications
Target:
Research Areas:
ML390 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor. ML390 is an inducer of myeloid differentiation and causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) acute myeloid leukemia (AML) models .
2
2 Cited Publications
Synonyms: JNJ-75276617; Menin-MLL inhibitor 24
Target:
Research Areas:
Bleximenib (JNJ-75276617) is an orally active and selective menin-KMT2A inhibitor, with IC50 values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. Bleximenib can inhibit the proliferation and induce apoptosis and differentiation of tumor cells. Bleximenib can be used in the research of tumors such as leukemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
