149

SB 202190 hydrochloride

149 Publications Verification

Cat. No.: HY-10295A

CAS No.: 350228-36-3

Purity: 99.66%

Target:

Organoid p38 MAPK Autophagy Apoptosis

Research Areas:

Neurological Disease Cancer

SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor with IC₅₀s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a K_d of 38 nM. SB 202190 hydrochloride has anti-cancer activity . SB202190 hydrochloride induces autophagy .

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149

SB 202190

149 Publications Verification

Cat. No.: HY-10295

CAS No.: 152121-30-7

Purity: 99.89%

Target:

Organoid p38 MAPK Autophagy Apoptosis

Research Areas:

Neurological Disease Cancer

SB 202190 is a selective p38 MAP kinase inhibitor with IC₅₀s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 binds to the ATP pocket of the active recombinant human p38 kinase with a K_d of 38 nM. SB 202190 has anti-cancer activity and rescued memory deficits . SB202190 induces autophagy .

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59

Raleukin

59 Cited Publications

Cat. No.: HY-108841

CAS No.: 143090-92-0

Purity: 99.40%

Synonyms: Kineret; Anakinra

Raleukin (Kineret) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin significantly reduces neutrophil accumulation in blood vessels and brain infarct volume as well as improves motor coordination performance in ischemic stroke mice model. Anakinra can be used to study chronic inflammatory disorders like rheumatoid arthritis and cardiovascular recurrence post-myocardial infarction .

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35

RS 504393

35 Cited Publications

Cat. No.: HY-15418

CAS No.: 300816-15-3

Purity: 99.23%

Target:

CCR

Research Areas:

Inflammation/Immunology Endocrinology

RS 504393 is a selective CCR2 chemokine receptor antagonist (IC₅₀ values are 89 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively).

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31

SB 239063

31 Cited Publications

Cat. No.: HY-11068

CAS No.: 193551-21-2

Purity: 99.15%

Target:

p38 MAPK Autophagy

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

SB 239063 is a potent, selective and orally active p38 MAPK inhibitor, exhibits an IC₅₀ of 44 nM for recombinant purified human p38α, with equipotent inhibitory activity against p38α and p38β. SB 239063 has no effect on p38γ or p38δ. With anti-asthma activity and also be used to enhance memory which is impaired due to aging or medical conditions, such as, AD. SB 239063 can penetrate the blood brain barrier (BBB) .

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21

Hyaluronidase (human recombinant)

21 Cited Publications

Cat. No.: HY-108903

CAS No.: 37326-33-3

Synonyms: Vorhyaluronidase alfa; rHuPH 20

Target:

Biochemical Assay Reagents Glycosidase

Research Areas:

Metabolic Disease

Hyaluronidase (human recombinant) (Vorhyaluronidase alfa; rHuPH 20) is an enzyme that catalyzes the degradation of hyaluronic acid. Hyaluronidase (human recombinant) is used to improve the absorption and dispersal of parenteral fluids, medications, and contrast media .

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16

Numidargistat

16 Cited Publications

Cat. No.: HY-101979

CAS No.: 2095732-06-0

Purity: ≥98.0%

Synonyms: CB-1158; INCB01158

Target:

Arginase

Research Areas:

Cancer

Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC₅₀s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent .

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16

Numidargistat dihydrochloride

16 Cited Publications

Cat. No.: HY-101979A

Purity: 98.65%

Synonyms: CB-1158 dihydrochloride; INCB01158 dihydrochloride

Target:

Arginase

Research Areas:

Cancer

Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of arginase, with IC₅₀s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent .

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16

6-Thioguanine

16 Cited Publications

Cat. No.: HY-13765

CAS No.: 154-42-7

Purity: 99.90%

Synonyms: Thioguanine; 2-Amino-6-purinethiol

Category:

Infection Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:

SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite

6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

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13

AM095 free acid

13 Cited Publications

Cat. No.: HY-16040

CAS No.: 1228690-36-5

Target:

LPL Receptor

Research Areas:

Inflammation/Immunology

AM095 (free acid) is a potent LPA1 receptor antagonist with IC₅₀ values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.

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12

GK921

12 Cited Publications

Cat. No.: HY-12337

CAS No.: 1025015-40-0

Purity: 99.91%

Target:

Glutaminase

Research Areas:

Cancer

GK921 is a transglutaminase 2 (TGase) inhibitor with an IC₅₀ of 7.71 μM for human recombinant TGase 2.

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11

Protein G Agarose

11 Cited Publications

Cat. No.: HY-K0214

MCE Protein G Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein G, effectively purifies mammalian monoclonal and polyclonal antibodies, such as human IgG3 and rat IgG2a.

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11

Fibronectin

11 Cited Publications

Cat. No.: HY-P3160

CAS No.: 86088-83-7

Target:

Integrin

Research Areas:

Cardiovascular Disease Inflammation/Immunology

Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .
This product is a human Fibronectin obtained by recombinant expression in a rice expression system.

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8

Recombinant human lysozyme (plant expression)

8 Cited Publications

Cat. No.: HY-P1068A

CAS No.: 9001-63-2

Target:

Bacterial

Research Areas:

Infection

Recombinant human lysozyme (plant expression) is a conserved anti-bacterial protein that causes bacterial lysis and death by hydrolyzing bacterial cell wall peptidoglycan (PG). Recombinant human lysozyme (plant expression) can be used to study bacterial infections .

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8

MD2-IN-1

8 Cited Publications

Cat. No.: HY-103483

CAS No.: 111797-22-9

Purity: 99.88%

Target:

Toll-like Receptor (TLR)

Research Areas:

Inflammation/Immunology

MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).

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7

KH7

7 Cited Publications

Cat. No.: HY-103194

CAS No.: 330676-02-3

Purity: ≥99.0%

Target:

Adenylate Cyclase

Research Areas:

Others

KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC₅₀s of 3-10 μM toward both recombinant purified human sAC_t protein and heterologously expressed sACt in cellular assays . KH7 is also a cAMP inhibitor .

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6

Tanshinone I

6 Cited Publications

Cat. No.: HY-N0134

CAS No.: 568-73-0

Synonyms: Tanshinone A

Category:

Terpenoids 500 - Internal Server Error | MedChemExpress

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