21

c-di-AMP disodium

21 Publications Verification

Cat. No.: HY-12326A

CAS No.: 2734909-87-4

Synonyms: Cyclic diadenylate disodium; Cyclic-di-AMP disodium

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

STING Bacterial Endogenous Metabolite

c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

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21

c-di-AMP diammonium

21 Publications Verification

Cat. No.: HY-12326B

Purity: 99.36%

Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

STING Bacterial Endogenous Metabolite

c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

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10

Ethacrynic acid

10 Cited Publications

Cat. No.: HY-B1640

CAS No.: 58-54-8

Synonyms: Etacrynic acid

Target:

Wnt Glutathione S-transferase NF-κB Calcium Channel NO Synthase

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

Ethacrynic acid has anti-inflammatory and anticancer activity. Ethacrynic acid is an orally active diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferase (GSTs) and Wnt signaling pathways. Ethacrynic acid is a radiosensitizer. Ethacrynic acid can inhibit airway smooth muscle (ASM) contraction in mice. Ethacrynic acid can increase the outflow of aqueous humor from the eye for the study of glaucoma .

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8

QS-21-Api

8 Cited Publications

Cat. No.: HY-101092

CAS No.: 141256-04-4

Purity: 99.67%

Synonyms: Stimulon

Category:

Triterpenes Terpenoids Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:

NOD-like Receptor (NLR)

QS-21-Api, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21-Api stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21-Api can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 .

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6

(S)-Timolol maleate

6 Cited Publications

Cat. No.: HY-17380

CAS No.: 26921-17-5

Synonyms: (S)-L-714,465 maleate; MK 950

Target:

Adrenergic Receptor

Research Areas:

Cardiovascular Disease Neurological Disease Cancer

(S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction .

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6

Latanoprost

6 Cited Publications

Cat. No.: HY-B0577

CAS No.: 130209-82-4

Synonyms: PHXA41

Target:

Prostaglandin Receptor

Research Areas:

Cardiovascular Disease Others

Latanoprost (PHXA41) is a prostaglandin F2α analogue and can be used for glaucoma research. Latanoprost can effectively pass through cornea and be hydrolyzed by esterase to latanoprost acid. latanoprost acid is an F-prostaglandin (FP) receptor agonist, and can effectively reduce intraocular pressure (IOP) by increasing the outflow of aqueous humor through uvea .

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2

Pidotimod

2 Cited Publications

Cat. No.: HY-B0944

CAS No.: 121808-62-6

Target:

Bacterial

Research Areas:

Inflammation/Immunology

Pidotimod is an orally active dipeptide immunostimulant with immunomodulatory properties on the adaptive and the innate immune responses. Pidotimod increases macrophage activity and humoral immune functions. Pidotimod can be used for the research of chronic bronchitis, chronic obstructive pulmonary disease (COPD), bronchiectasis, and chronic idiopathic urticaria,et al .

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