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326 Results for "

hydrocarbon

" in MedChemExpress (MCE) Product Catalog:

Products (326)

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434

PD98059

434 Publications Verification

Cat. No.: HY-12028

CAS No.: 167869-21-8

Purity: 98.89%

Target:

MEK ERK Aryl Hydrocarbon Receptor Autophagy

Research Areas:

Cancer

PD98059 is a potent and selective MEK inhibitor with an IC₅₀ of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC₅₀ of 2-7 µM) and MEK2 (IC₅₀ of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC₅₀ of 4 μM) and AHR transformation (IC₅₀ of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy .

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126

CH-223191

126 Cited Publications

Cat. No.: HY-12684

CAS No.: 301326-22-7

Purity: 99.96%

Target:

Aryl Hydrocarbon Receptor

Research Areas:

Cancer

CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC₅₀ of 0.03 μM .

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109

Pifithrin-α hydrobromide

109 Cited Publications

Cat. No.: HY-15484

CAS No.: 63208-82-2

Purity: 98.58%

Synonyms: Pifithrin hydrobromide; PFTα hydrobromide

Target:

MDM-2/p53 Aryl Hydrocarbon Receptor Ferroptosis Apoptosis

Research Areas:

Cancer

Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.

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FICZ

36 Cited Publications

Cat. No.: HY-12451

CAS No.: 172922-91-7

Purity: 98.57%

Synonyms: 6-Formylindolo[3,2-b]carbazole

Target:

Aryl Hydrocarbon Receptor

Research Areas:

Others

FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a K_d of 70 pM.

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L-Kynurenine

32 Cited Publications

Cat. No.: HY-104026

CAS No.: 2922-83-0

Purity: 99.93%

Category:

Cardiovascular Disease Human Gut Microbiota Metabolites Neurological Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Aryl Hydrocarbon Receptor Endogenous Metabolite

L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

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L-Kynurenine sulfate

32 Cited Publications

Cat. No.: HY-104026B

CAS No.: 16055-80-4

Category:

Alkaloids Human Gut Microbiota Metabolites Other Alkaloids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite Aryl Hydrocarbon Receptor

L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

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