52

Oxidopamine hydrobromide

52 Publications Verification

Cat. No.: HY-B1081A

CAS No.: 636-00-0

Synonyms: 6-Hydroxydopamine hydrobromide; 6-OHDA hydrobromide

Target:

Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase

Research Areas:

Neurological Disease Cancer

Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrobromide is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrobromide promotes COX-2 activation, leading to PGE₂ synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrobromide can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome .

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52

Oxidopamine hydrochloride

52 Publications Verification

Cat. No.: HY-B1081

CAS No.: 28094-15-7

Synonyms: 6-Hydroxydopamine Hydrochloride

Target:

Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase

Research Areas:

Neurological Disease Cancer

Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE₂ synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome .

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6

Pimelic Diphenylamide 106

6 Cited Publications

Cat. No.: HY-19348

CAS No.: 937039-45-7

Synonyms: RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII

Target:

HDAC Monoamine Transporter

Research Areas:

Neurological Disease Cancer

Pimelic Diphenylamide 106 (TC-H 106) is a slow, tight binding class I HDAC inhibitor (inhibits HDAC1, 2, and 3 with IC₅₀ values of 150 nM, 760 nM, and 370 nM, respectively), with no activity against class II HDACs. Pimelic Diphenylamide 106 modulates dopamine concentration and protects dopamine cells by inducing VMAT2 expression. Pimelic Diphenylamide 106 can be used in the study of neuropsychiatric diseases such as attention deficit hyperactivity disorder (ADHD) .

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4

Atomoxetine hydrochloride

4 Cited Publications

Cat. No.: HY-17385

CAS No.: 82248-59-7

Synonyms: Tomoxetine hydrochloride; (R)-Tomoxetine hydrochloride; LY 139603

Target:

Adrenergic Receptor Serotonin Transporter Sodium Channel

Research Areas:

Neurological Disease Cancer

Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with K_i values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .

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4

Atomoxetine

4 Cited Publications

Cat. No.: HY-107370

CAS No.: 83015-26-3

Synonyms: Tomoxetine; (R)-Tomoxetine

Target:

Serotonin Transporter Sodium Channel

Research Areas:

Neurological Disease Cancer

Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research .

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4

4-Aminohippuric acid

4 Cited Publications

Cat. No.: HY-B1306

CAS No.: 61-78-9

Synonyms: p-Aminohippuric acid

Category:

Other Diseases Disease Research Fields

Target:

Others

4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu ²⁺, Fe ³⁺, Hg ²⁺) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) .

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3

Guanfacine hydrochloride

3 Cited Publications

Cat. No.: HY-17416

CAS No.: 29110-48-3

Target:

Adrenergic Receptor

Research Areas:

Cardiovascular Disease Infection Neurological Disease Metabolic Disease

Guanfacine hydrochloride is an orally active and blood-brain barrier permeability noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD) .

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3

Guanfacine

3 Cited Publications

Cat. No.: HY-17416A

CAS No.: 29110-47-2

Target:

Adrenergic Receptor

Research Areas:

Cardiovascular Disease Neurological Disease Endocrinology

Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD) .

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2

CP-809101 hydrochloride

2 Cited Publications

Cat. No.: HY-15543A

CAS No.: 1215721-40-6

Purity: 99.37%

Target:

5-HT Receptor

Research Areas:

Neurological Disease

CP-809101 hydrochloride is a potent and highly selective 5-HT_2C receptor agonist, with pEC₅₀s of 9.96, 7.19 and 6.81 M for human 5HT_2C, 5HT_2B and 5HT_2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence .

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