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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
hyperemia
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "hyperemia" in MCE Product Catalog:
Synonyms: SYL1001 sodium
Research Areas:
Tivanisiran sodium (SYL1001 sodium) is a small interfering RNA (siRNA) targeting TRPV1 . Tivanisiran sodium induces the degradation of TRPV1 mRNA, thereby inhibiting protein synthesis. Tivanisiran sodium alleviates ocular discomfort and pain, and improves ocular hyperemia and tear quality. Tivanisiran sodium is applicable to research related to dry eye disease .
Synonyms: PHP-201; AMA0076
Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil lowers intraocular pressure (IOP) without inducing hyperemia .
Synonyms: SYL1001
Research Areas:
Tivanisiran (SYL1001) is a small interfering RNA (siRNA) targeting TRPV1 . Tivanisiran induces the degradation of TRPV1 mRNA, thereby inhibiting protein synthesis. Tivanisiran alleviates ocular discomfort and pain, and improves ocular hyperemia and tear quality. Tivanisiran is applicable to research related to dry eye disease .
Synonyms: PHP-201 hydrochloride; AMA0076 hydrochloride
Target:
Research Areas:
Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia .
Target:
Research Areas:
17-Phenyl trinor PGF2α isopropyl ester is a FP receptor agonist and intraocular pressure-lowering agent. 17-Phenyl trinor PGF2α isopropyl ester induces iris sphincter contraction, reduces intraocular pressure and pupil diameter, causes no ocular irritation, and only leads to mild conjunctival hyperemia. 17-Phenyl trinor PGF2α isopropyl ester is applicable to relevant research on glaucoma .
Cat. No.: HY-106037
CAS No.: 53764-90-2
Target:
Research Areas:
PGF2α-isopropyl ester is a Prostaglandin F2α (HY-12956) derivative, which is active in lowering the intraocular pressure (IOP) through increased uveoscleral outflow of aqueous humor. PGF2α-isopropyl ester causes side effects of conjunctival hyperemia and ocular irritation .
Cat. No.: HY-113858
CAS No.: 103880-26-8
Synonyms: Brefanolol
Target:
Research Areas:
Brefonalol (Brefanolol) is an orally active, non-selective β-adrenergic receptor blocker with vasodilatory properties. Brefonalol exhibits an optimal balance between β-blockade and vasodilatory effects at low doses: it reduces blood pressure and slows heart rate, while increasing stroke volume instead of decreasing it, causing no significant elevation in peripheral resistance and increasing reactive hyperemia; at high doses, the β-blockade effect dominates. Brefonalol can be used in the research of arterial hypertension .
Cat. No.: HY-109191AR
CAS No.: 2984963-50-8
Synonyms: PHP-201 hydrochloride (Standard); AMA0076 hydrochloride (Standard)
Target:
Research Areas:
Sovesudil hydrochloride (Standard) is the analytical standard of Sovesudil (hydrochloride) (HY-109191A). This product is intended for research and analytical applications. Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho Kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia .
Cat. No.: HY-189808
Target:
Research Areas:
GD134 is a histamine H1/H4 receptor antagonist that antagonizes H1R and blocks histamine-induced signaling; it acts as an inverse agonist at H4R. GD134 exhibits negligible hERG binding affinity. GD134 reduces ocular hyperemia in a mouse conjunctival allergen challenge model without increasing the squinting score. GD134 can be used for research on allergic conjunctivitis .
Cat. No.: HY-113858A
CAS No.: 3026677-28-8
Synonyms: Brefanolol hydrochloride
Target:
Research Areas:
Brefonalol (Brefanolol) hydrochloride is an orally active, non-selective β-adrenergic receptor blocker with vasodilatory properties. Brefonalol hydrochloride exhibits an optimal balance between β-blockade and vasodilatory effects at low doses: it reduces blood pressure and slows heart rate, while increasing stroke volume instead of decreasing it, causing no significant elevation in peripheral resistance and increasing reactive hyperemia; at high doses, the β-blockade effect dominates. Brefonalol hydrochloride can be used in the research of arterial hypertension .
Cat. No.: HY-167153
CAS No.: 2186644-51-7
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Cat. No.: HY-189807
Synonyms: VUF10775
Target:
Research Areas:
GD136 (VUF10775) is a histamine H1/H4 receptor antagonist that blocks histamine signaling. The pKi of GD136 for H1 is 7.61 (human), 7.80 (mouse), and 7.44 (rat), and for H4 is 7.93 (human), 7.38 (mouse), 7.28 (rat), and 7.38 (monkey). GD136 alleviates ocular hyperemia. GD136 can be used in research on allergic conjunctivitis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
