90 Results for "

hyperpolarize

" in MedChemExpress (MCE) Product Catalog:
Products (90)

90 Results for "hyperpolarize" in MCE Product Catalog:

70
Leupeptin hemisulfate
Leupeptin hemisulfate
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70 Publications Verification
Cat. No.: HY-18234A
CAS No.: 103476-89-7
Category:  

Natural Products Microorganisms Disease Research Fields Inflammation/Immunology

Target:  

Ser/Thr Protease Cathepsin Autophagy SARS-CoV Atg8/LC3 NO Synthase COX p62 Arginase PTEN NF-κB PI3K Akt p38 MAPK ERK Reactive Oxygen Species (ROS)

Leupeptin hemisulfate is a broad-spectrum protease inhibitor . By inhibiting the activation of the PTEN/PI3K/Akt/NF-κB/ERK1/2/p38 signaling pathway, Leupeptin hemisulfate significantly reduces LPS-induced NO and ROS production, mitochondrial membrane potential hyperpolarization, phagocytic activity, pro-inflammatory cytokine release, and M1 polarization in mouse peritoneal macrophages, and reverses autophagic flux impairment. It also decreases Concanavalin A (HY-P2149)-induced proliferation index of mouse splenic lymphocytes and the Th1/IL-10 and Th2/IL-10 cytokine ratios, thereby modulating innate and adaptive immune responses. Leupeptin hemisulfate inhibits blood coagulation and tumorigenesis in mouse skin. Leupeptin hemisulfate can be used in research on chronic inflammatory diseases and skin tumorigenesis .
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44
Bicuculline
Bicuculline
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44 Cited Publications
Cat. No.: HY-N0219
CAS No.: 485-49-4
Synonyms: (+)-Bicuculline
Category:  

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