300 Results for "

hypoxia

" in MedChemExpress (MCE) Product Catalog:
Products (300)

300 Results for "hypoxia" in MCE Product Catalog:

122
PX-478
PX-478
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122 Publications Verification
Cat. No.: HY-10231
CAS No.: 685898-44-6
Purity:  ≥98.0%
Target:  

HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy

Research Areas:  

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer

PX-478 is a multifunctional HIF-1α inhibitor with properties including radiosensitization, autophagy activation, and lipid accumulation inhibition. PX-478 also blocks hypoxia-induced VEGF production and regulates β-cell phenotypes under hypoxic conditions. PX-478 induces cell cycle arrest and DNA damage, restores autophagic function, reduces foam cell formation, and maintains glucose homeostasis. PX-478 is widely used in research on related diseases such as human tumors (e.g., prostate cancer), type 2 diabetes, and atherosclerosis .
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76
Minocycline hydrochloride
Minocycline hydrochloride
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76 Cited Publications
Cat. No.: HY-17412
CAS No.: 13614-98-7
Target:  

Bacterial Antibiotic HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53 Potassium Channel Calcium Channel

Research Areas:  

Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .
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76
Minocycline
Minocycline
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76 Cited Publications
Cat. No.: HY-17412A
CAS No.: 10118-90-8
Target:  

Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53 Potassium Channel Calcium Channel

Research Areas:  

Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .
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75
Camptothecin
Camptothecin
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75 Cited Publications
Cat. No.: HY-16560
CAS No.: 7689-03-4
Synonyms: Campathecin; (S)-(+)-Camptothecin; CPT
Category:  

Infection Nyssaceae Extract Alkaloids Quinoline Alkaloids 500 - Internal Server Error | MedChemExpress

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