24

Ivosidenib

24 Publications Verification

Cat. No.: HY-18767

CAS No.: 1448347-49-6

Synonyms: AG-120

Target:

Isocitrate Dehydrogenase (IDH)

Research Areas:

Infection Metabolic Disease Cancer

Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity .

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23

DS18561882

23 Cited Publications

Cat. No.: HY-130251

CAS No.: 2227149-22-4

Purity: 99.87%

Target:

Methylenetetrahydrofolate Dehydrogenase (MTHFD)

Research Areas:

Cancer

DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC₅₀ value of 0.0063 μM. DS18561882 also has inhibitory effect on MTHFD1 (IC₅₀=0.57 μM). DS18561882 exhibits a good oral pharmacokinetic profile .

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18

Belzutifan

18 Cited Publications

Cat. No.: HY-125840

CAS No.: 1672668-24-4

Purity: 99.85%

Synonyms: PT2977; MK-6482

Target:

HIF/HIF Prolyl-Hydroxylase

Research Areas:

Cancer

Belzutifan (PT2977) is an orally active and selective HIF-2α inhibitor with an IC₅₀ of 9 nM. Belzutifan, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. Belzutifan is a potential treatment for clear cell renal cell carcinoma (ccRCC) .

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11

GLPG1205

11 Cited Publications

Cat. No.: HY-135303

CAS No.: 1445847-37-9

Purity: 99.94%

Target:

GPR84

Research Areas:

Inflammation/Immunology

GLPG1205 is potent, selective and orally active GPR84 (a G-protein-coupled receptor) antagonist with a favorable PK/PD profile. GLPG1205 has anti-inflammatory activity and is used for the treatment of pulmonary fibrosis . GLPG1205 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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6

Itaconate-alkyne

6 Cited Publications

Cat. No.: HY-133870

CAS No.: 2454181-83-8

Purity: 98.01%

Synonyms: ITalk

Target:

Fluorescent Dye

Research Areas:

Inflammation/Immunology

Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate . Itaconate-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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5

Diroximel fumarate

5 Cited Publications

Cat. No.: HY-100375

CAS No.: 1577222-14-0

Purity: 99.90%

Synonyms: ALKS 8700; BIIB098

Target:

Keap1-Nrf2

Research Areas:

Inflammation/Immunology

Diroximel fumarate (ALKS 8700) is an orally-active and well-tolerated monomethyl fumarate (MMF) proagent in a controlled-release formulation. Diroximel fumarate is considered as active equivalent to its active metabolite dimethyl fumarate (DMF). Diroximel fumarate has a favorable safety and efficacy profile, has the potential for the study of multiple sclerosis (MS). Diroximel fumarate is a Nrf2 activator that alleviate MGO-induced pain hypersensitivity .

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5

Lincomycin hydrochloride

5 Cited Publications

Cat. No.: HY-B0417A

CAS No.: 859-18-7

Synonyms: U10149A

Category:

Infection Microorganisms Antibiotics Mammalian Cell Culture Disease Research Antibacterial Disease Research Fields Other Antibiotics Plant agriculture research

Target:

DNA/RNA Synthesis Antibiotic Bacterial

Lincomycin hydrochloride (U10149A) is an orally active lincosamide antibiotic. Lincomycin hydrochloride binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice ^[3].

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5

Lincomycin

5 Cited Publications

Cat. No.: HY-117660

CAS No.: 154-21-2

Purity: 99.82%

Synonyms: U-10149

Category:

Infection Alkaloids Microorganisms Pyrrole Alkaloids Disease Research Fields

Target:

Antibiotic Bacterial DNA/RNA Synthesis

Lincomycin (U-10149) is an orally active lincosamide antibiotic. Lincomycin binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice ^[3].

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5

Lincomycin hydrochloride monohydrate

5 Cited Publications

Cat. No.: HY-B1358

CAS No.: 7179-49-9

Synonyms: U-10149 hydrochloride monohydrate

Category:

Infection Microorganisms Antibiotics Mammalian Cell Culture Disease Research Antibacterial Disease Research Fields Other Antibiotics Plant agriculture research

Target:

DNA/RNA Synthesis Antibiotic Bacterial

Lincomycin (U-10149) hydrochloride monohydrate is an orally active lincosamide antibiotic. Lincomycin hydrochloride monohydrate binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride monohydrate can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride monohydrate induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice ^[3].

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5

NAI-N3

5 Cited Publications

Cat. No.: HY-103006

CAS No.: 1612756-29-2

Purity: 99.93%

Target:

Biochemical Assay Reagents

Research Areas:

Others

NAI-N3 is a RNA acylation reagent that enables RNA purification. NAI-N3 is a dual-function SHAPE (selective 2-hydroxyl acylation and profiling experiment) probe (RNA structure probe and enrichment) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

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4

Spinosad

4 Cited Publications

Cat. No.: HY-138800

CAS No.: 168316-95-8

Purity: 96.19%

Category:

Natural Products Microorganisms Neurological Disease Disease Research Fields Biological Pesticide Research Agricultural Research

Target:

nAChR

Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete (Saccharopolyspora spinosa), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. Spinosad has an excellent environmental and mammalian toxicological profile. Larvicidal activity ^[3].

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4

IA-Alkyne

4 Cited Publications

Cat. No.: HY-136205

CAS No.: 930800-38-7

Purity: 99.41%

Synonyms: Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide

Target:

TRP Channel

Research Areas:

Infection Inflammation/Immunology

IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection . IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling . IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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3

Hydroxocobalamin monohydrochloride

3 Cited Publications

Cat. No.: HY-B2209A

CAS No.: 59461-30-2

Synonyms: Vitamin B12a monohydrochloride

Category:

Human Gut Microbiota Metabolites Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Hydroxocobalamin monohydrochloride (Vitamin B12a monohydrochloride) is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia .

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3

NS11394

3 Cited Publications

Cat. No.: HY-11048

CAS No.: 951650-22-9

Purity: 99.77%

Target:

GABA Receptor

Research Areas:

Neurological Disease

NS11394 is an orally active and unique subtype-selective GABA_A positive allosteric receptor (PAM), with a K_i of ~0.5 nM. NS11394 shows a selectivity profile in the order of GABA_A-5 > α3 > α2 > α1-containing receptors. NS11394 has anxiolytic and anti-inflammatory properties ^[3].

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3

DDO-2728

3 Cited Publications

Cat. No.: HY-155489

CAS No.: 3029515-97-4

Purity: 98.55%

Target:

Anaplastic lymphoma kinase (ALK) Apoptosis

Research Areas:

Cancer

DDO-2728 (compound 19) is a selective AlkB homologue 5 (ALKBH5) inhibitor with an IC₅₀ of 2.97 μM. DDO-2728 increases the abundance of N ⁶ methyladenosine (m ⁶A) modifications, inducing cell apoptosis and cycle arrest. DDO-2728 suppresses tumor growth in the MV4 11 xenograft model with favorable safety profile, shows the potential of targeting ALKBH5 in cancer research .

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3

Hydroxocobalamin

3 Cited Publications

Cat. No.: HY-B2209

CAS No.: 13422-51-0

Synonyms: Vitamin B12a

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Hydroxocobalamin (Vitamin B12a) is a cyanide antidote. Hydroxocobalamin can decrease the cell and plasma cyanide concentrations and increase survival rate in acute cyanide poisoning. Hydroxocobalamin can improve newborn Cbl-C defect-induced metabolic profile and neurocognitive outcome. Hydroxocobalamin can normalize Vitamin B₁₂ deficiency. Hydroxocobalamin can induce acute kidney injury. Hydroxocobalamin can be used for the researches of metabolic and neurological disease ^[3] .

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2

Ibuzatrelvir

2 Cited Publications

Cat. No.: HY-156654

CAS No.: 2755812-39-4

Purity: 99.90%

Synonyms: PF-07817883

Target:

SARS-CoV Virus Protease

Research Areas:

Infection

Ibuzatrelvir (PF-07817883), a second-generation, orally bioavailable, is SARS-CoV-2 main protease (M ^pro and 3CL ^pro) inhibitor with improved metabolic stability. Ibuzatrelvir has demonstrated pan-human coronavirus antiviral activity and off-target selectivity profile in vitro and in preclinical animal studies. Ibuzatrelvir is well tolerated with a safety profile similar to placebo and prevents viral infection and transmission. Ibuzatrelvir can be used to inhibit COVID-19 ^[3] .

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2

BMS-582949 hydrochloride

2 Cited Publications

Cat. No.: HY-14305A

CAS No.: 912806-16-7

Purity: 98.90%

Target:

p38 MAPK Autophagy

Research Areas:

Inflammation/Immunology

BMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor, with an IC₅₀ of 13 nM. BMS-582949 hydrochloride displays a significantly improved pharmacokinetic profile and is effective in inflammatory disease .

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2

Quercetin 3,7-dimethyl ether

2 Cited Publications

Cat. No.: HY-N1798

CAS No.: 2068-02-2

Category:

Cardiovascular Disease Flavonols Flavonoids 500 - Internal Server Error | MedChemExpress

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iBH3 profiling

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