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238 Results for "

iNOS expression

" in MedChemExpress (MCE) Product Catalog:

Products (238)

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Methotrexate

94 Publications Verification

Cat. No.: HY-14519

CAS No.: 59-05-2

Purity: 99.87%

Synonyms: Amethopterin; CL14377; WR19039

Target:

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Research Areas:

Inflammation/Immunology Cancer

Methotrexate (Amethopterin; CL14377; WR19039) is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .

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Methotrexate hydrate

94 Publications Verification

Cat. No.: HY-14519B

CAS No.: 133073-73-1

Purity: 98.41%

Synonyms: Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate

Target:

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Methotrexate hydrate (Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate) is an orally active antifolate (Antifolate). Methotrexate hydrate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate hydrate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate hydrate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate hydrate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .

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Methotrexate disodium

94 Publications Verification

Cat. No.: HY-14519A

CAS No.: 7413-34-5

Purity: 99.71%

Synonyms: Amethopterin disodium; CL14377 disodium; WR19039 disodium

Target:

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Methotrexate disodium (Amethopterin disodium; CL14377 disodium; WR19039 disodium) is an orally active antifolate (Antifolate). Methotrexate disodium inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate disodium promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate disodium induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate disodium is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .

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