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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
iPLA2β
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "iPLA2β" in MCE Product Catalog:
3
3 Cited Publications
Synonyms: (6E)-Bromoenol lactone
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Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca 2+ influx [2].
2
2 Cited Publications
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Research Areas:
FKGK18 is a selective group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor. FKGK18 is a fluoroketone (FK)-based compound with IC50s of 50 nM and 3 μM for iPLA2β and iPLA2γ. FKGK18 can be used for the research of beta-cell apoptosis and diabetes [2] .
Synonyms: (S)-BEL; (S,E)-Bromoenol lactone
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Research Areas:
(S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 µM .
Cat. No.: HY-187855
CAS No.: 17364-19-1
Synonyms: 18:0-LPC
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Research Areas:
1-Stearoyl-lysophosphatidylcholine (18:0-LPC) is a lysophosphatidylcholine generated by iPLA2β-mediated hydrolysis of phosphatidylcholine and present in circulating LDL; under different hydration conditions, it can form a bilayer gel phase, bilayer liquid crystalline phase, or micellar phase, and serves as a key metabolic node in the JSRV-induced OPA protein-metabolite network. 1-Stearoyl-lysophosphatidylcholine can be used in research on nonalcoholic steatohepatitis and ovine pulmonary adenocarcinoma [2] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
