31 Results for "

ileal

" in MedChemExpress (MCE) Product Catalog:
Products (31)

31 Results for "ileal" in MCE Product Catalog:

4
Odevixibat
Odevixibat
0 Images
4 Cited Publications
Cat. No.: HY-109120
CAS No.: 501692-44-0
Purity:  99.92%
Synonyms: A4250
Target:  

Apical Sodium-Dependent Bile Acid Transporter

Research Areas:  

Metabolic Disease

Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .
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1
Rebaudioside D
Rebaudioside D
0 Images
1 Cited Publications
Cat. No.: HY-N0468
CAS No.: 63279-13-0
Category:  

Terpenoids Metabolic Disease Diterpenoids Plants Other Families Extract Disease Research Fields Sweeteners Food Research

Target:  

FXR Acetyl-CoA Carboxylase

Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research .
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Maralixibat chloride
Maralixibat chloride
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Cat. No.: HY-16747
CAS No.: 228113-66-4
Synonyms: SHP625 chloride; LUM001 chloride; Lopixibat chloride
Target:  

Apical Sodium-Dependent Bile Acid Transporter

Research Areas:  

Metabolic Disease

Maralixibat (SHP625) chloride is an orally active ileal bile acid transporter (IBAT) inhibitor. Maralixibat chloride can be used for the research of rare cholestatic liver diseases including Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC) and biliary atresia .
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Lipopolysaccharides, from E. coli O127:B8
Lipopolysaccharides, from E. coli O127:B8
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Cat. No.: HY-D1056A2
Synonyms: LPS, from Escherichia coli (O127:B8)
Lipopolysaccharides, from E. coli O127:B8 (LPS, from Escherichia coli (O127:B8)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O127:B8) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O127:B8 possess the typical three-part structure: O-antigen, R3-type core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O127:B8 activate TLR-4 in immune cells, can induce inflammatory responses and ileal contractility, and can be used to construct intestinal inflammation models .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
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Guvacoline hydrochloride
Guvacoline hydrochloride
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Cat. No.: HY-N5016
CAS No.: 6197-39-3
Category:  

Cardiovascular Disease Alkaloids Pyridine Alkaloids Plants 500 - Internal Server Error | MedChemExpress

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