84 Results for "

immunosuppression

" in MedChemExpress (MCE) Product Catalog:
Products (84)

84 Results for "immunosuppression" in MCE Product Catalog:

68
Daporinad
Daporinad
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68 Publications Verification
Cat. No.: HY-50876
CAS No.: 658084-64-1
Synonyms: FK866; APO866
Target:  

NAMPT Autophagy Apoptosis mTOR p38 MAPK ERK

Research Areas:  

Cancer

Daporinad (FK866) is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a Ki value of 0.3 nM. Daporinad depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad causes the depletion of the endoplasmic reticulum Ca²⁺ pool, ultimately weakening the mitogen-induced Ca²⁺ signal and the activation and function of T cells. Daporinad induces cell cycle arrest and apoptosis, and inhibits cell proliferation. Daporinad can be used for the study of myeloma, liver cancer, and immunosuppression .
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22
Genipin
Genipin
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22 Cited Publications
Cat. No.: HY-17389
CAS No.: 6902-77-8
Synonyms: (+)-Genipin
Category:  

Neurological Disease Metabolic Disease Plants Endogenous metabolite Human Gut Microbiota Metabolites Iridoids Terpenoids 500 - Internal Server Error | MedChemExpress

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