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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
inflammatory demyelination
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "inflammatory demyelination" in MCE Product Catalog:
Cat. No.: HY-173591
CAS No.: 2785323-68-2
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
T0080 is a central nervous system-penetrant FPR1 inhibitor. By functionally blocking the FPR1 signaling pathway, T0080 effectively reduces neutrophil infiltration into ischemic brain tissue and maintains the integrity of the blood-brain barrier. T0080 alleviates tPA-associated hemorrhagic transformation, inhibits demyelination responses and the expression of NOX2. T0080 also possesses anti-apoptotic (apoptosis) and anti-inflammatory properties, thereby protecting myelin and reducing neurological deficits. T0080 is widely used in studies related to ischemic stroke complicated by hemorrhagic transformation after tPA thrombolysis, as well as multiple sclerosis .
Cat. No.: HY-108058A
CAS No.: 699020-93-4
Research Areas:
Immethridine dihydrobromide is a selective histamine H3 receptor agonist. Immethridine dihydrobromide inhibits the expression of TLR4/CD14 and the phosphorylation of NF-κB p65. Immethridine dihydrobromide reduces inverse agonist-induced scratching, induces cheek-directed wiping rather than itching, and exerts a protective effect against HCl-induced gastric mucosal injury without affecting gastric acid secretion. Immethridine dihydrobromide attenuates experimental autoimmune encephalomyelitis and reduces inflammatory infiltration/demyelination in the spinal cord. Immethridine dihydrobromide can be used in research on autism spectrum disorders .
Cat. No.: HY-108058
CAS No.: 87976-03-2
Research Areas:
Immethridine is a selective histamine H3 receptor agonist. Immethridine inhibits the expression of TLR4/CD14 and the phosphorylation of NF-κB p65. Immethridine reduces inverse agonist-induced scratching, induces cheek-directed wiping rather than itching, and exerts a protective effect against HCl-induced gastric mucosal injury without affecting gastric acid secretion. Immethridine attenuates experimental autoimmune encephalomyelitis and reduces inflammatory infiltration/demyelination in the spinal cord. Immethridine can be used in research on autism spectrum disorders .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
