7

Budesonide

7 Cited Publications

Cat. No.: HY-13580

CAS No.: 51333-22-3

Purity: 99.75%

Target:

Glucocorticoid Receptor ADC Payloads

Research Areas:

Inflammation/Immunology Cancer

Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

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5

Aclidinium Bromide

5 Cited Publications

Cat. No.: HY-14144

CAS No.: 320345-99-1

Purity: 98.58%

Synonyms: LAS 34273; LAS-W 330

Target:

mAChR

Research Areas:

Inflammation/Immunology

Aclidinium Bromide (LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist. Aclidinium Bromide has the potential for chronic obstructive pulmonary disease (COPD) research .

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3

PC786

3 Cited Publications

Cat. No.: HY-102038

CAS No.: 1902114-15-1

Purity: 99.11%

Target:

RSV

Research Areas:

Infection

PC786 is an inhaled respiratory syncytial virus (RSV) L protein polymerase inhibitor. PC786 demonstrates potent antiviral activity against RSV-A (IC₅₀ <0.09 to 0.71 nM) and RSV-B (IC₅₀, 1.3 to 50.6 nM) .

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2

Seralutinib

2 Cited Publications

Cat. No.: HY-109190

CAS No.: 1619931-27-9

Purity: 99.94%

Synonyms: GB002; PK10571

Target:

PDGFR c-Fms c-Kit

Research Areas:

Cardiovascular Disease

Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. Seralutinib also targets to CSF1R and c-KIT with IC₅₀s of 8 nM and 14 nM, respectively. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension .

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2

AZD5423

2 Cited Publications

Cat. No.: HY-108243

CAS No.: 1034148-04-3

Purity: 99.85%

Target:

Glucocorticoid Receptor

Research Areas:

Inflammation/Immunology Endocrinology

AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM) . AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma .

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2

Stepronin

2 Cited Publications

Cat. No.: HY-A0234

CAS No.: 72324-18-6

Synonyms: Prostenoglycine; TTPG; Tiase

Target:

Chloride Channel

Research Areas:

Endocrinology

Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl ^- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands .

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1

Ensifentrine

1 Cited Publications

Cat. No.: HY-119708

CAS No.: 1884461-72-6

Purity: 99.70%

Synonyms: RPL-554

Target:

Phosphodiesterase (PDE)

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Ensifentrine (RPL-554) is an inhaled dual inhibitor of PDE3 and PDE4 with IC₅₀s of 0.4 nM and 1479 nM, respectively. Ensifentrine blocks PDE3 and PDE4 enzymes, thereby increasing the levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in lung cells, dilating the bronchi, and inhibiting the activation and migration of inflammatory cells. Ensifentrine can be used in the research of chronic obstructive pulmonary disease (COPD) .

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1

Phosphatidylglycerols (egg) sodium salt

1 Cited Publications

Cat. No.: HY-W251428

CAS No.: 383907-64-0

Synonyms: Egg PG

Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein CD14/MD-2 complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit COX-2 expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV) .

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1

Dornase alfa

1 Cited Publications

Cat. No.: HY-108858

CAS No.: 143831-71-4

Synonyms: rhDNase

Target:

DNA/RNA Synthesis Endonuclease

Research Areas:

Inflammation/Immunology

Dornase alfa (rhDNase) is a recombinant human deoxyribonuclease I (rhDNase) that can specifically degrade extracellular DNA. Dornase alfa catalyzes the cleavage of DNA released by neutrophils in respiratory mucus, reduces sputum viscosity, thereby improving mucus clearance efficiency, reducing airway obstruction and alleviating inflammatory responses. Dornase alfa can be used to improve lung function (such as FEV_1) in cystic fibrosis (CF), reduce the risk of acute pulmonary exacerbations, and has good in vivo tolerability. Dornase alfa acts locally on the respiratory tract through aerosol inhalation, specifically improving the high viscosity of mucus caused by DNA accumulation and related respiratory symptoms .

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1

L-Perillaldehyde

1 Cited Publications

Cat. No.: HY-N2085

CAS No.: 18031-40-8

Synonyms: (S)-(-)-Perillaldehyde; (S)-Perillaldehyde

Category:

Other Monoterpenes Neurological Disease Terpenoids 500 - Internal Server Error | MedChemExpress

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