109

109 Publications Verification

Target:

Research Areas:

Insulin (human) is a polypeptide hormone that regulates the level of glucose. Insulin (human) can be used for the diabetes mellitus .

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109

Insulin solution (human)

109 Publications Verification

Cat. No.: HY-P0035A

CAS No.: 11061-68-0

Target:

Insulin Receptor

Research Areas:

Metabolic Disease

Insulin solution (human) is a polypeptide hormone that regulates the level of glucose. Insulin solution (human) can be used for the diabetes mellitus .

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72

Exendin-4 acetate

72 Cited Publications

Cat. No.: HY-13443A

CAS No.: 914454-01-6

Purity: 99.91%

Synonyms: Exenatide acetate

Target:

GLP Receptor Apoptosis

Research Areas:

Cardiovascular Disease Metabolic Disease

Exendin-4 acetate (Exenatide acetate) is an orally active, blood-brain barrier-permeable glucagon-like peptide-1 receptor (GLP‑1 receptor) agonist that resists degradation mediated by dipeptidyl peptidase IV. Exendin-4 acetate mediates multiple glucose-regulating effects, including stimulation of glucose-dependent insulin secretion, inhibition of glucagon production, increase in β-cell mass, delay of gastric emptying, reduction of food intake, improvement of peripheral insulin sensitivity, and restoration of normal islet structure. Exendin-4 acetate inhibits oxidative stress, alleviates inflammatory responses, and reduces neuronal apoptosis. Exendin-4 acetate reduces the aggregation level of mutant huntingtin, improves motor function, prolongs survival time, and regulates the expression levels of leptin and ghrelin. Exendin-4 acetate can be used in research related to type 2 diabetes, acute ischemic stroke, and Huntington's disease .

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72

Exendin-4

72 Cited Publications

Cat. No.: HY-13443

CAS No.: 141758-74-9

Purity: 99.95%

Synonyms: Exenatide

Target:

GLP Receptor Apoptosis

Research Areas:

Cardiovascular Disease Metabolic Disease

Exendin‑4 (Exenatide) is an orally active, blood-brain barrier-permeable glucagon-like peptide-1 receptor (GLP‑1 receptor) agonist that resists degradation mediated by dipeptidyl peptidase IV. Exendin‑4 mediates multiple glucose-regulating effects, including stimulation of glucose-dependent insulin secretion, inhibition of glucagon production, increase in β-cell mass, delay of gastric emptying, reduction of food intake, improvement of peripheral insulin sensitivity, and restoration of normal islet structure. Exendin‑4 inhibits oxidative stress, alleviates inflammatory responses, and reduces neuronal apoptosis. Exendin‑4 reduces the aggregation level of mutant huntingtin, improves motor function, prolongs survival time, and regulates the expression levels of leptin and ghrelin. Exendin‑4 can be used in research related to type 2 diabetes, acute ischemic stroke, and Huntington's disease .

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35

NCT-503

35 Cited Publications

Cat. No.: HY-101966

CAS No.: 1916571-90-8

Purity: 99.69%

Target:

Phosphoglycerate Dehydrogenase (PHGDH)

Research Areas:

Metabolic Disease Cancer

NCT-503 is a blood-brain barrier-permeable, non-competitive PHGDH inhibitor with an IC₅₀ of 2.5 μM against human PHGDH. NCT-503 reduces glucose-derived serine production and the incorporation of one-carbon units into nucleotides without decreasing PHGDH protein expression. NCT-503 prevents high selenium-induced insulin resistance in mice by regulating blood glucose and insulin levels and improving glucose tolerance, and also inhibits the growth of tumors overexpressing PHGDH. NCT-503 can be used in research related to insulin resistance and breast cancer .

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29

Tirzepatide sodium

29 Cited Publications

Cat. No.: HY-P1731C

Synonyms: LY3298176 sodium

Target:

GLP Receptor Insulin Receptor Apoptosis mTOR

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Cancer

Tirzepatide sodium (LY3298176 sodium) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide sodium exerts anti-apoptotic and pro-differentiation effects via the pAkt/CREB/BDNF cascade and miRNA in neurons; in the heart, it promotes BCAA catabolism and inhibits the mTOR pathway by mediating the dephosphorylation of BCKDHA; meanwhile, it effectively reduces insulin and leptin levels and suppresses inflammatory responses at the systemic level. Tirzepatide sodium can be used for research on myocardial infarction, colon cancer, diabetes, diabetic cognitive impairment, neurodegeneration, diabetes-related neuropathy, and obesity .

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18

D-Mannitol

18 Cited Publications

Cat. No.: HY-N0378

CAS No.: 69-65-8

Synonyms: Mannitol; Mannite

Category:

Natural Products Metabolic Disease Plants Other Families Extract Endogenous metabolite Disease Research Fields Sweeteners Food Research

Target:

Environmental Pollutants Endogenous Metabolite Apoptosis PGC-1α PKA Adrenergic Receptor

D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells . D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed .

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14

Olitigaltin

14 Cited Publications

Cat. No.: HY-19940

CAS No.: 1450824-22-2

Synonyms: TD139; GB0139

Target:

Galectin Akt β-catenin Apoptosis ERK

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Olitigaltin (TD139) is a high-affinity Galectin-3 inhibitor with a K_d value of 14 nM. Olitigaltin inhibits the activity of the AKT/β-catenin pathway, induces Apoptosis, and downregulates SREBP1 expression. Olitigaltin enhances the phosphorylation level of ERK. Olitigaltin alleviates bleomycin (HY-17565A)-induced advanced pulmonary fibrosis in mice. Olitigaltin delays the onset of diabetes, and improves glucose tolerance and serum insulin levels. Olitigaltin alleviates liver injury. Olitigaltin maintains the structure of hippocampal excitatory synapses, restores γ-wave power in the hippocampal CA1 region, inhibits hippocampal neuroinflammation, and improves cognitive function in neuroinflammation models. Olitigaltin can be used in research related to thyroid cancer, idiopathic pulmonary fibrosis, type 1 diabetes, hepatitis, and cognitive dysfunction induced by neuroinflammation .

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12

JBSNF-000088

12 Cited Publications

Cat. No.: HY-112584

CAS No.: 7150-23-4

Purity: 99.94%

Synonyms: 6-Methoxynicotinamide

Target:

Amine N-methyltransferase

Research Areas:

Metabolic Disease

JBSNF-000088 (6-Methoxynicotinamide), a analog of nicotinamide (NA), is a potent and orally active Nicotinamide N-methyltransferase (NNMT) inhibitor with IC₅₀s of 1.8 µM, 2.8 µM, and 5.0 µM for human NNMT, monkey NNMT and mouse NNMT, respectively. JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease .

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8

Setmelanotide

8 Cited Publications

Cat. No.: HY-19870

CAS No.: 920014-72-8

Synonyms: RM-493; BIM-22493; IRC-022493

Target:

Melanocortin Receptor Calmodulin AMPK

Setmelanotide (RM-493) is a blood-brain barrier-permeable, selective MC4R agonist with a K_i value of 2.1 nM for hMC4R. Setmelanotide activates the CaMKK2/AMPK signaling pathway. Setmelanotide mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression .

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8

Setmelanotide monoacetate

8 Cited Publications

Cat. No.: HY-19870C

CAS No.: 2759937-80-7

Synonyms: RM-493 monoacetate; BIM-22493 monoacetate; IRC-022493 monoacetate

Target:

Melanocortin Receptor Calmodulin AMPK

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology

Setmelanotide monoacetate (RM-493 monoacetate) is a blood-brain barrier-permeable, selective MC4R agonist with a K_i value of 2.1 nM for hMC4R. Setmelanotide monoacetate activates the CaMKK2/AMPK signaling pathway. Setmelanotide monoacetate mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide monoacetate is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression .

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6

MDL12330A

6 Cited Publications

Cat. No.: HY-103192

CAS No.: 40297-09-4

Purity: 99.82%

Synonyms: RMI12330A

Target:

Adenylate Cyclase Potassium Channel

Research Areas:

Neurological Disease Cancer

MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit K_V channels, increases insulin secretion and Ca ²⁺ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease .

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5

Lincomycin hydrochloride

5 Cited Publications

Cat. No.: HY-B0417A

CAS No.: 859-18-7

Synonyms: U10149A

Category:

Infection Microorganisms Antibiotics Mammalian Cell Culture Disease Research Antibacterial Disease Research Fields Other Antibiotics Plant agriculture research

Target:

DNA/RNA Synthesis Antibiotic Bacterial

Lincomycin hydrochloride (U10149A) is an orally active lincosamide antibiotic. Lincomycin hydrochloride binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice .

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5

Lincomycin

5 Cited Publications

Cat. No.: HY-117660

CAS No.: 154-21-2

Purity: 99.82%

Synonyms: U-10149

Category:

Infection Alkaloids Microorganisms Pyrrole Alkaloids Disease Research Fields

Target:

Antibiotic Bacterial DNA/RNA Synthesis

Lincomycin (U-10149) is an orally active lincosamide antibiotic. Lincomycin binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice .

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5

Lincomycin hydrochloride monohydrate

5 Cited Publications

Cat. No.: HY-B1358

CAS No.: 7179-49-9

Synonyms: U-10149 hydrochloride monohydrate

Category:

Infection Microorganisms Antibiotics Mammalian Cell Culture Disease Research Antibacterial Disease Research Fields Other Antibiotics Plant agriculture research

Target:

DNA/RNA Synthesis Antibiotic Bacterial

Lincomycin (U-10149) hydrochloride monohydrate is an orally active lincosamide antibiotic. Lincomycin hydrochloride monohydrate binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride monohydrate can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride monohydrate induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice .

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