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7 Results for "

intact platelets

" in MedChemExpress (MCE) Product Catalog:

Products (7)

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1-Oleoyl-2-acetyl-sn-glycerol

2 Cited Publications

Cat. No.: HY-131648

CAS No.: 86390-77-4

Purity: ≥99.0%

Target:

Drug Derivative PKC TRP Channel

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer

1-Oleoyl-2-acetyl-sn-glycerol is a cell-permeable analog of diacylglycerol (DAG) and can activate Protein kinase C (PKC). 1-Oleoyl-2-acetyl-sn-glycerol can activate the TRPC channels-mediated specific Ca ²⁺ influx. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate superoxide-generation from human neutrophils. 1-Oleoyl-2-acetyl-sn-glycerol stimulates the formation of phosphatidylinositol 4-phosphate in intact human platelets. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate ascites tumor cell proliferation .

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Siguazodan

Cat. No.: HY-19026

CAS No.: 115344-47-3

Synonyms: SKF 94836

Target:

Phosphodiesterase (PDE)

Research Areas:

Cardiovascular Disease

Siguazodan (SKF 94836) is a potent, selective and orally active phosphodiesterase III (PDE-III) inhibitor with an IC₅₀ of 117 nM. Siguazodan increases cAMP accumulation in intact platelets with an EC₅₀ of 18.88 μM. Siguazodan also inhibits phenylephrine-induced 5-HT release with an IC₅₀ value of 4.2 μM .

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2-Methyl-3-phenylquinoxaline

Cat. No.: HY-113876

CAS No.: 10130-23-1

Target:

PDGFR

Research Areas:

Cancer

2-Methyl-3-phenylquinoxaline (compound 38) is a potent platelet-derived growth factor receptor tyrosine kinase (PDGF-RTK) inhibitor with modest inhibitory activity against PDGFR kinase in intact cells (IC₅₀ greater than 100 μM) .

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EP 171

Cat. No.: HY-118220

CAS No.: 122089-44-5

Target:

Thrombin

Research Areas:

Cardiovascular Disease

EP 171 is a TP receptor agonist and human platelet activator. EP 171 can induce constriction of guinea pig trachea, and the constriction can be inhibited by the TP receptor antagonist EP 092. EP 171 binds to TP receptors on intact human platelets with an IC₅₀ of 2.9 nM .

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