3 Results for "

intermediate-affinity

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "intermediate-affinity" in MCE Product Catalog:

Cat. No.: HY-P99752
CAS No.: 2315268-27-8
Synonyms: ALKS 4230; RDB-1450

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer .
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Cat. No.: HY-108738
CAS No.: 152923-56-3
Purity:  99.18%
Synonyms: Ro 24-7375
Daclizumab (Ro 24-7375) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab inhibits effector T cell activation, regulatory T cell (Treg) expansion and survival, and activation-induced T-cell apoptosis. Daclizumab increases IL-2 bioavailability to bind to the intermediate-affinity IL-2R (IL-2R-IA), driving the expansion of anti-inflammatory CD56bright natural killer (NK) cells. Daclizumab can be used for multiple sclerosis and cancer research .
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Cat. No.: HY-P991270

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

MT204 is a humanized IgG1 antibody inhibitor targeting IL-2 of human and rhesus monkey origin. MT204 prevents soluble IL-2 from binding to intermediate-affinity IL-2 receptors and blocks CD25-bound IL-2 on high-affinity IL-2 receptors. MT204 has potently anti-proliferative activity with NKL cells and primary NK cells. MT204 has good tolerability and potent immunosuppressive activity in allogeneic skin graft model of rhesus monkey, promising for immunosuppressive and anti-proliferative therapy .
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