3 Results for "

intestinal transit inducer

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "intestinal transit inducer" in MCE Product Catalog:

Casanthranol
Casanthranol
0 Images
Cat. No.: HY-B2134
CAS No.: 8024-48-4
Category:  

Natural Products Metabolic Disease Plants Other Families Extract Disease Research Fields

Target:  

α-synuclein

Casanthranol is a naturally derived, orally active mixture of anthraquinone glycosides that exhibits inhibitory activity against α-synuclein and bioactivities related to laxation . Casanthranol inhibits seed-induced α-synuclein fibrillation in cell-free systems and rescues preformed fibril-induced cytotoxicity in differentiated N2a cells. Casanthranol promotes intestinal transit in both the small and large intestines of mice with experimental constipation. Casanthranol can be used in research related to constipation .
loading...
    loading...
View All Sizes
Strictinin
Strictinin
0 Images
Cat. No.: HY-135319
CAS No.: 517-46-4
Purity:  97.15%
Category:  

Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Theaceae Extract

Target:  

Bacterial Antibiotic ERK JNK NF-κB ROR Apoptosis Caspase GSK-3 Akt PI3K

Strictinin is an orally active phenolic compound. Strictinin reduces xanthine oxidase activity, uric acid production, and the activation of ERK1/2, JNK, NF-κB, and NLRP3 inflammasome components in hepatocytes treated with Xanthine (HY-W017389). Strictinin decreases elevated serum uric acid levels and enhanced xanthine oxidase activity in mice treated with potassium oxonate. Strictinin acts as a ROR1 inhibitor and exhibits anticancer activity against highly aggressive non-androgen-dependent prostate cancer. Strictinin induces cancer cell apoptosis (apoptosis), arrests cell cycle, and inhibits cancer cell migration, invasion, and epithelial-mesenchymal transition. Strictinin modulates gut microbiota, inhibits bacterial growth and biofilm formation, accelerates small intestinal transit, and blocks viral entry and replication. Strictinin can be used in research related to hyperuricemia, androgen receptor-negative non-androgen-dependent prostate cancer, triple-negative breast cancer, bacterial infections, constipation, coronavirus infections, dental caries, and infections caused by influenza A, influenza B, and human parainfluenza virus type 1 .
loading...
    loading...
View All Sizes
AM841
AM841
0 Images
Cat. No.: HY-149933
CAS No.: 871978-21-1
Target:  

Cannabinoid Receptor

Research Areas:  

Neurological Disease Inflammation/Immunology

AM841 is a cannabinoid superagonist and a covalent, irreversible full agonist of CB1. AM841 can activate peripheral CB1 receptors to reduce excitatory neurotransmission and GI smooth muscle contractility, and inhibit synaptic transmission. AM841 is peripherally restricted at low doses in mice, with extremely low brain penetration, potently inhibits gastrointestinal motility, and can reverse acute stress-induced hyperaccelerated gastrointestinal transit; at high doses, it can produce the classic tetrad of central cannabinoid phenotypes (analgesia, catalepsy, hypothermia, decreased spontaneous activity). AM841 can improve intestinal inflammation in mouse colitis models. AM841 induces transient stress-induced hyperthermia. AM841 can be used for research on gastrointestinal motility disorders and colitis .
loading...
    loading...
View All Sizes
Assay Types