60

Imidazole ketone erastin

60 Publications Verification

Cat. No.: HY-114481

CAS No.: 1801530-11-9

Purity: 99.77%

Synonyms: IKE

Target:

Ferroptosis

Research Areas:

Cancer

Imidazole ketone erastin is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system x_c ^- and an activator of ferroptosis. Imidazole ketone erastin has anti-tumor activity .

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7

AACOCF3

7 Cited Publications

Cat. No.: HY-108611

CAS No.: 149301-79-1

Purity: ≥99.0%

Synonyms: Arachidonyl trifluoromethyl ketone

Target:

Phospholipase

Research Areas:

Cardiovascular Disease

AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease .

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7

Pregnenolone

7 Cited Publications

Cat. No.: HY-B0151

CAS No.: 145-13-1

Synonyms: 3β-Hydroxy-5-pregnen-20-one

Category:

Neurological Disease Anti-aging Endogenous metabolite Disease Research Fields Steroids

Target:

Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy

Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

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7

Pregnenolone monosulfate sodium

7 Cited Publications

Cat. No.: HY-110189

CAS No.: 1852-38-6

Purity: 99.96%

Synonyms: 3β-Hydroxy-5-pregnen-20-one monosulfate sodium

Category:

Endogenous metabolite Steroids

Target:

Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy

Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

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7

Pregnenolone monosulfate

7 Cited Publications

Cat. No.: HY-B1739

CAS No.: 1247-64-9

Synonyms: 3β-Hydroxy-5-pregnen-20-one monosulfate

Category:

Endogenous metabolite Steroids

Target:

Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy

Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication . Pregnenolone monosulfate is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

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5

Cuprizone

5 Cited Publications

Cat. No.: HY-W115718

CAS No.: 370-81-0

Target:

Dopamine β-hydroxylase

Research Areas:

Neurological Disease

Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) .

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3

Indole-3-pyruvic acid

3 Cited Publications

Cat. No.: HY-W028393

CAS No.: 392-12-1

Category:

Alkaloids Endogenous metabolite Disease Research Fields Inflammation/Immunology Indole Alkaloids

Target:

Endogenous Metabolite Aryl Hydrocarbon Receptor Interleukin Related COX Bcl-2 Family

Indole-3-pyruvic acid is an orally active ketone analog of tryptophan, and is an aryl hydrocarbon receptor (AHR) agonist. Indole-3-pyruvic acid inhibits p38/MAPK phosphorylation, regulates the tryptophan metabolic pathway, and also possesses protective activities against skin photodamage, as well as anti-inflammatory and anti-anxiety bioactivities in the gut. Indole-3-pyruvic acid can downregulate the expression of IL-1β, IL-6, Cox-2, and Bax to alleviate UVB-induced keratinocyte toxicity. Indole-3-pyruvic acid can activate AHR to promote Tr1 cell differentiation, increase IL-10, and inhibit Th1 cytokine production. Indole-3-pyruvic acid can alter the levels of kynurenine metabolites in the brain, mediating central nervous system-related effects. Indole-3-pyruvic acid can be used in research on skin lesions, colitis, and anxiety .

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2

N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride

2 Cited Publications

Cat. No.: HY-112716

CAS No.: 4272-74-6

Purity: ≥99.0%

Target:

Amino Acid Derivatives

Research Areas:

Cancer

N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.

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2

Ketone monoester

2 Cited Publications

Cat. No.: HY-15344

CAS No.: 1208313-97-6

Purity: ≥95.0%

Target:

Biochemical Assay Reagents

Research Areas:

Neurological Disease Metabolic Disease

Ketone monoester is an orally available ketone monoester that serves as a source of nutritional ketones. Ketone monoester increases plasma beta-hydroxybutyrate, acetoacetate, blood glucose, blood sodium, and blood creatinine levels in mouse models. Ketone monoester has the potential to improve athletic performance and endurance in animals. Ketone monoester partially prevents myasthenia in septic mice. Ketone monoester may also be used to study Parkinson's disease or diabetes .

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1

Raspberry ketone glucoside

1 Cited Publications

Cat. No.: HY-N6069

CAS No.: 38963-94-9

Category:

Ketones, Aldehydes, Acids Rosaceae Extract Plants 500 - Internal Server Error | MedChemExpress

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