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73 Results for "

kidney damage

" in MedChemExpress (MCE) Product Catalog:

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Neomycin sulfate

82 Publications Verification

Cat. No.: HY-B0470

CAS No.: 1405-10-3

Category:

Disease Research Antibacterial Other Antibiotics Infection Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields

Target:

Environmental Pollutants Antibiotic Phospholipase Bacterial

Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca ²⁺ release, MgATP-dependent Ca ²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca ²⁺ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer .

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L-Cysteine hydrochloride hydrate

14 Cited Publications

Cat. No.: HY-W016715

CAS No.: 7048-04-6

Category:

Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite NF-κB Insulin Receptor

L-Cysteine hydrochloride hydrate is an orally active and essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate regulates CBS/H2S pathway, inhibits NF-κB activation and insulin and ghrelin secretion. L-Cysteine hydrochloride hydrate reduces blood sugar, vascular inflammation markers and appetite. L-Cysteine hydrochloride hydrate induces kidney damage. L-Cysteine hydrochloride hydrate can be used in the study of neurological diseases and diabetes .

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L-Ornithine hydrochloride

10 Cited Publications

Cat. No.: HY-W017018

CAS No.: 3184-13-2

Category:

Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:

CaSR p38 MAPK Reactive Oxygen Species (ROS)

L-Ornithine hydrochloride is an orally active CaSR and p38 activator. L-Ornithine hydrochloride inhibits ROS and supports urea cycle function. L-Ornithine hydrochloride can be used to study kidney diseases involving proximal tubular cell damage caused by oxidative stress or crystallopathy, as well as research related to anxiety disorders .

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