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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
kinase-panel selectivity
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "kinase-panel selectivity" in MCE Product Catalog:
Cat. No.: HY-149075
CAS No.: 3027761-24-3
Target:
Research Areas:
MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells .
Cat. No.: HY-179599
CAS No.: 1448757-02-5
Research Areas:
Dyrk1A-IN-15 is a selective, brain-penetrant and ATP-competitive Dyrk1A inhibitor with a IC50 of 19 nM. Dyrk1A-IN-15 displays high selectivity across a broad kinase panel (specific for DYRK kinases) with nanomolar potency. Dyrk1A-IN-15 impairs neurosphere self-renewal, cell invasion, and EGFR stability in vitro. Dyrk1A-IN-15 inhibits tumor growth and prolongs survival in vivo. Dyrk1A-IN-15 has potential for glioblastoma (GBM) research .
Cat. No.: HY-179600
CAS No.: 2805339-74-4
Research Areas:
Dyrk1A-IN-16 is a selective, brain-penetrant and ATP-competitive Dyrk1A inhibitor with a IC50 of 53 nM. Dyrk1A-IN-16 displays high selectivity across a broad kinase panel (specific for DYRK kinases) with nanomolar potency. Dyrk1A-IN-16 impairs neurosphere self-renewal, cell invasion, and EGFR stability in vitro. Dyrk1A-IN-16 inhibits tumor growth and prolongs survival in vivo. Dyrk1A-IN-16 has potential for glioblastoma (GBM) research .
Cat. No.: HY-189673
FLT3-ITD-IN-4 is an orally active FLT3-ITD inhibitor. FLT3-ITD-IN-4 targets FLT3-ITD with an IC50 of 1.1 nM, blocking autophosphorylation and downstream STAT, AKT, and ERK signaling. FLT3-ITD-IN-4 shows weaker inhibition of wild-type FLT3, with PDGFRβ as the primary off-target, demonstrating selectivity across a broad kinase panel. FLT3-ITD-IN-4 induces cell cycle arrest, apoptosis, and DNA damage response. FLT3-ITD-IN-4 can be used for research on acute myeloid leukemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
