5 Results for "

kinetic analysis

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "kinetic analysis" in MCE Product Catalog:

Cat. No.: HY-137115
CAS No.: 334658-24-1
Target:  

Smo

Research Areas:  

Cancer

BODIPY-Cyclopamine is a fluorescently labeled ligand for the Smoothened (SMO) receptor. The activation of SMO is regulated by Patch protein, and over-activated SMO signaling pathways are associated with tumorigenesis. The NanoBRET (Nanofluorescein bioluminescence resonance energy transfer) technique used in the study can sensitively detect the resonance energy transfer between SMO and BODIPY-Cyclopamine, which can be used for high-throughput screening and kinetic analysis. Studying the binding site of BODIPY-Cyclopamine on SMO can also further explore SMO-targeted drugs .
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Cat. No.: HY-P3123A
Target:  

Fluorescent Dye

Research Areas:  

Others

Dnp-RPLALWRS TFA is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS TFA at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS TFA provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .
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Cat. No.: HY-P3123
CAS No.: 172666-82-9
Target:  

Fluorescent Dye

Research Areas:  

Others

Dnp-RPLALWRS is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .
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Cat. No.: HY-P5415
CAS No.: 127134-13-8
Target:  

HIV

Research Areas:  

Others

DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-Kd protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)
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Cat. No.: HY-175132
Synonyms: NBD L-threo cer (d18:1/12:0); NBD L-threo ceramide (d18:1/12:0); N-Dodecanoyl-NBD L-threo-sphingosine
Target:  

Fluorescent Dye

Research Areas:  

Others

C12 NBD L-threo Ceramide (d18:1/12:0) (NBD L-threo cer (d18:1/12:0); NBD L-threo ceramide (d18:1/12:0); N-Dodecanoyl-NBD L-threo-sphingosine) is an NBD fluorescently labeled ceramide analog. C12 NBD L-threo Ceramide (d18:1/12:0) is an isomer of C12 NBD ceramide. C12 NBD L-threo Ceramide (d18:1/12:0) can be used for fluorescence detection, imaging, and kinetic analysis.
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