293 Results for "

lesion

" in MedChemExpress (MCE) Product Catalog:
Products (293)

293 Results for "lesion" in MCE Product Catalog:

154
Erlotinib Hydrochloride
Erlotinib Hydrochloride
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154 Publications Verification
Cat. No.: HY-12008
CAS No.: 183319-69-9
Purity:  99.94%
Synonyms: CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride
Target:  

EGFR OAT ERK GSK-3 β-catenin

Research Areas:  

Endocrinology Cancer

Erlotinib (CP-358774) Hydrochloride is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib Hydrochloride also acts as a substrate and inhibitor of OATP2B1, with an IC50 of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib Hydrochloride blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib Hydrochloride inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2, GSK-3β and β-catenin signaling pathways, as well as the deposition of fibronectin, α-SMA, collagen and renal injury markers. Erlotinib Hydrochloride is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib Hydrochloride can be used in research related to non-small cell lung cancer, gastric cancer, papillary renal cell carcinoma, EGFR inhibitor resistance and renal fibrosis .
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154
Erlotinib
Erlotinib
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154 Publications Verification
Cat. No.: HY-50896
CAS No.: 183321-74-6
Synonyms: CP-358774; NSC 718781; OSI-774
Target:  

EGFR OAT ERK GSK-3 β-catenin

Research Areas:  

Endocrinology Cancer

Erlotinib (CP-358774) is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib also acts as a substrate and inhibitor of OATP2B1, with an IC50 of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2, GSK-3β and β-catenin signaling pathways, fibronectin, α-SMA, collagen deposition, and renal injury markers. Erlotinib is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib can be used in research related to non-small cell lung cancer, gastric cancer, papillary renal cell carcinoma, pancreatic cancer, renal fibrosis, and other conditions .
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20
Chlorin e6 trisodium
Chlorin e6 trisodium
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20 Cited Publications
Cat. No.: HY-W854659
CAS No.: 72984-36-2
Synonyms: Ce6 trisodium
Chlorin e6 Ce6 (trisodium) is a water-soluble derivative of chlorophyll, belonging to the chlorin class of photosensitizers with an absorption wavelength range of 600-670 nm. Chlorin e6 trisodium emits characteristic red fluorescence upon light excitation, enabling real-time identification of tumor boundaries and progression. Chlorin e6 trisodium can be used for the study of photodynamic therapy (PDT) of cancers (bladder cancer) and fluorescence diagnosis of neoplastic lesions .
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14
Tetrazolium Red
Tetrazolium Red
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14 Cited Publications
Cat. No.: HY-D0714
CAS No.: 298-96-4
Synonyms: 2,3,5-Triphenyltetrazolium chloride; TPTZ; TTC
Tetrazolium Red (2,3,5-Triphenyltetrazolium chloride; TTC) is a not brain-penetrant, colorless, water-soluble dye that is reduced by mitochondrial enzymes to a deep red, water-insoluble compound (formazan) mainly in the mitochondria of living cells. Tetrazolium Red is used to observe the activity of dehydrogenase, and it turns colorless to red when exposed to hydrogen. Tetrazolium Red distinguishes between surviving and infarcted brain tissue after stroke. Tetrazolium Red has been used to stain heart tissue to measure the extent of acute lesions and also used to stain brain tissue to detect the size of the infarcted area. The absorption wavelength of Tetrazolium Red is 570 nm .
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12
ATN-161
ATN-161
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12 Cited Publications
Cat. No.: HY-13535
CAS No.: 262438-43-7
Target:  

Integrin Apoptosis NOD-like Receptor (NLR) p38 MAPK Reactive Oxygen Species (ROS) SARS-CoV

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Cancer

ATN-161 is an antagonist of α5β1 integrin and αvβ3 integrin, as well as an inhibitor of fibrosis, an inhibitor of oxidative stress, a tight junction stabilizer, a mitochondrial integrity protector, an angiogenesis inhibitor and an antiviral agent. ATN-161 inhibits NLRP3, MAPK, and ROS. ATN-161 protects mice from SARS-CoV-2 infection . ATN-161 reduces infarct volume, alleviates edema, decreases immune cell infiltration, reduces the area of choroidal neovascularization lesions, lowers tumor microvessel density and viral load. ATN-161 can be used in research related to ischemic stroke, choroidal neovascularization, breast cancer, coronavirus disease 2019 (COVID-19), and liver metastasis of colorectal cancer .
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9
Tranylcypromine hemisulfate
Tranylcypromine hemisulfate
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9 Cited Publications
Cat. No.: HY-B1496
CAS No.: 13492-01-8
Synonyms: SKF 385 hemisulfate
Target:  

Monoamine Oxidase Histone Demethylase

Research Areas:  

Neurological Disease Cancer

Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects .
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8
PKR-IN-C16
PKR-IN-C16
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8 Cited Publications
Cat. No.: HY-13977A
CAS No.: 608512-97-6
Purity:  99.27%
Target:  

Apoptosis

Research Areas:  

Neurological Disease

PKR-IN-C16 (Compound C16) is a specific double-stranded RNA-dependent protein kinase (PKR) inhibitor. PKR-IN-C16 shows promising neuroprotective properties and can rescue acute brain lesions .
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6
Pyridoxylamine
Pyridoxylamine
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6 Cited Publications
Cat. No.: HY-B1745
CAS No.: 85-87-0
Category:  

Human Gut Microbiota Metabolites Natural Products Microorganisms Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.
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6
Pyridoxylamine dihydrochloride
Pyridoxylamine dihydrochloride
0 Images
6 Cited Publications
Cat. No.: HY-B1745A
CAS No.: 524-36-7
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Pyridoxylamine dihydrochloride is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions .
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5
TDI-011536
TDI-011536
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5 Cited Publications
Cat. No.: HY-150042
CAS No.: 2687970-96-1
Purity:  99.87%
Target:  

Large Tumor Suppressor (LATS) YAP

Research Areas:  

Cardiovascular Disease Others

TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration .
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5
Natalizumab
Natalizumab
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5 Cited Publications
Cat. No.: HY-108831
CAS No.: 189261-10-7
Purity:  99.10%

Target:  

Integrin

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

Natalizumab (AN100226; BG00002) is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d). It blocks the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 + T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thus exerting anti-inflammatory and immunomodulatory activity. Natalizumab is used in the study of relapsing-remitting multiple sclerosis (RRMS) and also has applications in the study of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab can also prevent lymphocytes from entering the central nervous system, thereby preventing acute demyelinating relapses .
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5
Natalizumab (Anti-CD49d)
Natalizumab (Anti-CD49d)
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5 Cited Publications
Cat. No.: HY-108831A
CAS No.: 189261-10-7
Purity:  98.72%
Synonyms: AN100226; BG00002

Target:  

Integrin

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

Natalizumab (Anti-CD49d) (AN100226; BG00002) Solution is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d), blocking the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab solution inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 + T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thereby exerting anti-inflammatory and immunomodulatory activity. Natalizumab (Anti-CD49d) solution is used in the study of relapsing-remitting multiple sclerosis (RRMS) and is also applied in the research of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab (Anti-CD49d) can also prevent lymphocytes from entering the central nervous system, thus preventing acute demyelinating relapses .
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4
Acridin-9-amine hydrochloride hydrate
Acridin-9-amine hydrochloride hydrate
0 Images
4 Cited Publications
Cat. No.: HY-W011950
CAS No.: 52417-22-8
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

Acridin-9-amine (9-Aminoacridine) hydrochloride hydrate is a mutagen and DNA modifier. Acridin-9-amine hydrochloride hydrate induces mutagenic lesions during DNA replication .
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4
Toluidine Blue
Toluidine Blue
0 Images
4 Cited Publications
Cat. No.: HY-D0220
CAS No.: 92-31-9
Synonyms: Toluidine Blue O
Target:  

Fluorescent Dye

Research Areas:  

Cancer

Toluidine Blue (Toluidine Blue O) is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue can stain different components of plant tissues and cells in different colours. Toluidine Blue is also used as a diagnostic aid to identify malignant lesions, such as cancer .
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4
Toluidine Blue (purity 36%)
Toluidine Blue (purity 36%)
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4 Cited Publications
Cat. No.: HY-D0220A
Synonyms: Toluidine Blue O (purity 36%)
Toluidine Blue (Toluidine Blue O) purity 36% is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue purity 36% shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue purity 36% can stain different components of plant tissues and cells in different colours. Toluidine Blue purity 36% is also used as a diagnostic aid to identify malignant lesions, such as cancer .
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3
Berberrubine chloride
Berberrubine chloride
0 Images
3 Cited Publications
Cat. No.: HY-125850
CAS No.: 15401-69-1
Purity:  99.28%
Category:  

Rutaceae Extract Alkaloids 500 - Internal Server Error | MedChemExpress

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