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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
licking
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "licking" in MCE Product Catalog:
Cat. No.: HY-P1192
CAS No.: 133156-06-6
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Cat. No.: HY-119174
CAS No.: 66537-55-1
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MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome .
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LY456066 is a selective non-competitive metabotropic glutamate receptors (mGluR1) antagonist with an IC50 value of 52.0 nM. LY456066 is effective in rodent models of anxiolysis and nociception. LY456066 reduces hyperalgesia and the amount of licking and flinching following formalin injection, which is promising for research of analgesics for chronic pain .
Cat. No.: HY-115889
CAS No.: 85697-89-8
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L-NAPNA is a nitric oxide synthase (NOS) inhibitor with an IC50 of 1.4 μM. L-NAPNA exhibits analgesic effects by inhibiting formalin-induced paw licking behavior in mice (ED50 of 57.2 mg/kg) and suppressing acetic acid-induced abdominal writhing in mice (ED50 of 25 mg/kg). L-NAPNA can be used in research related to central nervous system diseases .
Cat. No.: HY-182584
CAS No.: 153607-45-5
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S 15931 is a 5-HT1A receptor inhibitor. S 15931 inhibits the late-phase hindpaw licking response induced by formalin and the abdominal writhing response induced by acetic acid in Mus musculus. S 15931 abolishes the spontaneous tail-flick response induced by 8-OH-DPAT in Rattus norvegicus and potentiates the analgesic effect of morphine. S 15931 is applicable for pain-related research .
Cat. No.: HY-118973
CAS No.: 1807810-16-7
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LASSBio-1829 hydrochloride is an orally active IKK2 inhibitor with an IC50 of 3.8 μM against the human target (Sf21 cells). LASSBio-1829 hydrochloride blocks signal transduction of the inflammation-associated NF-κB activation pathway. LASSBio-1829 hydrochloride reduces leukocyte migration, TNF-α biosynthesis, ROS production and NO production. LASSBio-1829 hydrochloride exhibits anti-inflammatory activity in a carrageenan-induced subcutaneous air pouch mouse model. LASSBio-1829 hydrochloride alleviates licking behavior during the inflammatory phase of the mouse formalin test. LASSBio-1829 hydrochloride can be used in inflammation-related research .
Cat. No.: HY-189394
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AS2-10 is a cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 3.6 μM. AS2-10 inhibits COX-2 through hydrogen bonding and electrostatic interactions within the catalytic pocket, and also exhibits inhibitory activity against COX-1. AS2-10 possesses peripheral analgesic and anti-inflammatory effects, alleviating acetic acid-induced writhing, formalin-induced licking responses, and Carrageenan (HY-125474)-induced paw edema. AS2-10 can be used in research related to inflammation and pain .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
