6022 Results for "

light chain polypeptide sequences

" in MedChemExpress (MCE) Product Catalog:
Products (6022)

6022 Results for "light chain polypeptide sequences" in MCE Product Catalog:

669
ML385
ML385
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669 Publications Verification
Cat. No.: HY-100523
CAS No.: 846557-71-9
Purity:  99.96%
Target:  

Keap1-Nrf2 Ferroptosis Apoptosis mTOR

Research Areas:  

Cardiovascular Disease Cancer

ML385 is a potent and selective Nrf2 inhibitor with an IC50 of 1.9 μM. ML385 directly binds to the Neh1 domain of NRF2, interferes with the binding of the MAFG-NRF2 protein complex to the antioxidant response element (ARE) DNA sequence, thereby blocking the expression of downstream target genes of NRF2. ML385 can be used in studies related to adult T-cell leukemia, breast cancer, myocardial ischemia/reperfusion injury, non-small cell lung cancer, esophageal squamous cell carcinoma, head and neck squamous cell carcinoma, and lung squamous cell carcinoma .
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223
Metformin hydrochloride
Metformin hydrochloride
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223 Cited Publications
Cat. No.: HY-17471A
CAS No.: 1115-70-4
Synonyms: 1,1-Dimethylbiguanide hydrochloride
Target:  

AMPK Autophagy Mitophagy Apoptosis mTOR

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
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223
Metformin
Metformin
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223 Cited Publications
Cat. No.: HY-B0627
CAS No.: 657-24-9
Synonyms: 1,1-Dimethylbiguanide
Target:  

AMPK Autophagy Mitophagy Apoptosis mTOR

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
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215
Rotenone
Rotenone
0 Images
215 Cited Publications
Cat. No.: HY-B1756
CAS No.: 83-79-4
Category:  

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