339 Results for "

lignan

" in MedChemExpress (MCE) Product Catalog:
Products (339)

339 Results for "lignan" in MCE Product Catalog:

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17
Arctigenin
Arctigenin
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17 Publications Verification
Cat. No.: HY-N0035
CAS No.: 7770-78-7
Synonyms: (-)-Arctigenin
Category:  

Neurological Disease Anti-aging Lignans Metabolic Disease Compositae/Asteraceae Extract Endogenous metabolite Infection Human Gut Microbiota Metabolites Plant Arctium lappa L. Extract Phenylpropanoids Disease Research Fields Inflammation/Immunology Cancer

Target:  

MMP Influenza Virus Autophagy Apoptosis

Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions .
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12
Sesamin
Sesamin
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12 Cited Publications
Cat. No.: HY-N0121
CAS No.: 607-80-7
Category:  

Plant Neurological Disease Anti-aging Pedaliaceae Extract Lignans Phenylpropanoids Disease Research Fields Sesamum indicum Linn. Extract

Target:  

Stearoyl-CoA Desaturase (SCD)

Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .
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9
Magnolol
Magnolol
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9 Cited Publications
Cat. No.: HY-N0163
CAS No.: 528-43-8
Category:  

Cardiovascular Disease Neurological Disease Magnolia officinalis. Rehd. et Wils./Houpoea officinalis (Rehder & E. H. Wilson) N. H. Xia & C. Y. Wu Extract Lignans Plant Phenols Polyphenols Phenylpropanoids Magnoliaceae Extract Disease Research Fields Inflammation/Immunology

Target:  

RAR/RXR PPAR Autophagy Bacterial

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.
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7
Secoisolariciresinol diglucoside
Secoisolariciresinol diglucoside
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7 Cited Publications
Cat. No.: HY-105008
CAS No.: 257930-74-8
Purity:  99.74%
Synonyms: (S,S)-SDG; (S,S)-LGM2605
Category:  

Cardiovascular Disease Neurological Disease Linaceae Extract Lignans Plant Phenols Polyphenols Linum usitatissimum Linn. Extract Phenylpropanoids Disease Research Fields

Target:  

Free Radical Scavengers

Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects .
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6
Macelignan
Macelignan
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6 Cited Publications
Cat. No.: HY-N0064
CAS No.: 107534-93-0
Synonyms: (+)-Anwulignan; Anwuligan
Category:  

Neurological Disease Lignans Metabolic Disease Schisandraceae Extract Plant Monophenols Schisandra chinensis (Turcz.) Baill. Extract Phenols Phenylpropanoids Disease Research Fields Inflammation/Immunology

Target:  

COX

Macelignan ((+)-Anwulignan; Anwuligan)?is an orally active lignan isolated from Myristica fragrans. Macelignan possesses many pharmacological activities, including anti-inflammatory, anti-cancer, anti-diabetes, and neuroprotective activities .
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5
Schisandrin C
Schisandrin C
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5 Cited Publications
Cat. No.: HY-N0690
CAS No.: 61301-33-5
Synonyms: Schizandrin-C; Wuweizisu-C
Category:  

Plant Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenylpropanoids Schisandraceae Extract Disease Research Fields Cancer

Target:  

Apoptosis

Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis . Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory and antioxidant effects. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases research . Schisandrin C induces cell apoptosis .
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4
Schisandrin
Schisandrin
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4 Cited Publications
Cat. No.: HY-N0691
CAS No.: 7432-28-2
Synonyms: Schizandrin; Schizandrol; Schizandrol-A
Category:  

Plant Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenylpropanoids Schisandraceae Extract Disease Research Fields Cancer

Target:  

Autophagy

Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .
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3
Schisantherin A
Schisantherin A
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3 Cited Publications
Cat. No.: HY-N0694
CAS No.: 58546-56-8
Synonyms: Gomisin-C; Schizantherin-A; Wuweizi ester-A
Category:  

Plant Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenylpropanoids Schisandraceae Extract Disease Research Fields Inflammation/Immunology

Target:  

NF-κB

Schisantherin A is a dibenzocyclooctadiene lignan. Schisantherin A inhibits p65-NF-κB translocation into the nucleus by IκBα degradation.
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3
Gomisin J
Gomisin J
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3 Cited Publications
Cat. No.: HY-N0385
CAS No.: 66280-25-9
Category:  

Cardiovascular Disease Plant Monophenols Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenols Phenylpropanoids Schisandraceae Extract Disease Research Fields

Target:  

NO Synthase AMPK CaMK NF-κB Keap1-Nrf2

Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .
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1
Obovatol
Obovatol
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1 Cited Publications
Cat. No.: HY-N8259
CAS No.: 83864-78-2
Category:  

Plant Houpoea obovata (Thunberg) N. H. Xia & C. Y. Wu Extract Other Diseases Lignans Phenols Polyphenols Phenylpropanoids Magnoliaceae Extract Disease Research Fields

Target:  

Others

Obovatol is a biphenyl ether lignan isolated from the leaves of Magnolia obovata Thunb .
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1
Matairesinoside
Matairesinoside
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1 Cited Publications
Cat. No.: HY-N7996
CAS No.: 23202-85-9
Category:  

Infection Plant Monophenols Forsythia Extract Lignans Phenols Phenylpropanoids Oleaceae Extract Disease Research Fields

Target:  

Free Radical Scavengers Bacterial Fungal

Matairesinoside is a lignan with antibacterial and antioxidant activities. Matairesinoside also shows virus-cell fusion inhibitory activity .
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1
(+)-Syringaresinol
(+)-Syringaresinol
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1 Cited Publications
Cat. No.: HY-126030
CAS No.: 21453-69-0
Purity:  98.69%
Category:  

Plant Parthenium hysterophorus Linn. Extract Lignans Phenols Polyphenols Phenylpropanoids Compositae/Asteraceae Extract Disease Research Fields Cancer

Target:  

Nuclear Factor of activated T Cells (NFAT)

(+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC50 of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia .
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1
Epimagnolin A
Epimagnolin A
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1 Cited Publications
Cat. No.: HY-N5107
CAS No.: 41689-51-4
Synonyms: (+)-epi-Magnolin
Category:  

Infection Plant Lignans Phenylpropanoids Other Families Extract Disease Research Fields

Target:  

Parasite

Epimagnolin A, a furfuran lignan, shows mild antiplasmodial activities (IC50=5.7 μg/mL) without noticeable toxicity on mammalian normal cells .
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1
Secoisolariciresinol
Secoisolariciresinol
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1 Cited Publications
Cat. No.: HY-N6071
CAS No.: 29388-59-8
Synonyms: (-)-Secoisolariciresinol
Category:  

Lignans Other Families Extract Endogenous metabolite Human Gut Microbiota Metabolites Plant Other Diseases Phenols Polyphenols Phenylpropanoids Disease Research Fields

Target:  

Drug Intermediate

Secoisolariciresinol ((-)-Secoisolariciresinol) is a plant lignan and a precursor of enterolignans. Secoisolariciresinol can be converted into enterodiol and enterolactone by intestinal microflora. Secoisolariciresinol may reduce the risk of cancer and cardiovascular diseases .
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1
Chicanine
Chicanine
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1 Cited Publications
Cat. No.: HY-N2270
CAS No.: 78919-28-5
Category:  

Plant Monophenols Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenols Phenylpropanoids Schisandraceae Extract Disease Research Fields Inflammation/Immunology

Target:  

p38 MAPK ERK IKK

Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity .
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1
Sauchinone
Sauchinone
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1 Cited Publications
Cat. No.: HY-N0613
CAS No.: 177931-17-8
Category:  

Saururus chinensis (Lour.) Baill. Extract Plant Terpenoids Diterpenoids Disease Research Fields Inflammation/Immunology Saururaceae Extract

Target:  

NF-κB

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .
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1
Secoisolariciresinol (Standard)
Secoisolariciresinol (Standard)
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1 Cited Publications
Cat. No.: HY-N6071R
CAS No.: 29388-59-8
Synonyms: (-)-Secoisolariciresinol (Standard)
Category:  

Human Gut Microbiota Metabolites Plant Lignans Phenols Polyphenols Phenylpropanoids Other Families Extract Endogenous metabolite

Target:  

Reference Standards Drug Intermediate

Artemether (Standard) ((-)-Secoisolariciresinol (Standard)) is the analytical standard of Artemether (HY-N6071). This product is intended for research and analytical applications. Secoisolariciresinol ((-)-Secoisolariciresinol) is a plant lignan and a precursor of enterolignans. Secoisolariciresinol can be converted into enterodiol and enterolactone by intestinal microflora. Secoisolariciresinol may reduce the risk of cancer and cardiovascular diseases .
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1
(-)-Asarinin
(-)-Asarinin
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1 Cited Publications
Cat. No.: HY-N0701
CAS No.: 133-04-0
Category:  

Plant Aristolochiaceae Extract Lignans Phenylpropanoids Asarum sieboldii Miq. Extract Disease Research Fields Cancer

Target:  

Apoptosis Reactive Oxygen Species (ROS) STAT Src Stearoyl-CoA Desaturase (SCD) Bacterial

(-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive Δ5-desaturase inhibitor with a Ki of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects .
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1
(+)-Medioresinol
(+)-Medioresinol
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1 Cited Publications
Cat. No.: HY-N3307
CAS No.: 40957-99-1
Category:  

Cardiovascular Disease Plant Neurological Disease Fraxinus mandshurica Rupr. Extract Phenols Polyphenols Oleaceae Extract Disease Research Fields

Target:  

Bacterial Fungal Reactive Oxygen Species (ROS) Apoptosis MMP Interleukin Related PI3K Akt mTOR PPAR PGC-1α Pyroptosis

(+)-Medioresinol is a furofuran-type lignan with antifungal and antibacterial properties. (+)-Medioresinol synergizes with antibiotics to exert antimicrobial and antibiofilm effects. (+)-Medioresinol induces intracellular ROS accumulation and mitochondrial-mediated apoptosis in Candida albicans. (+)-Medioresinol inhibits LPS (HY-D1056)-stimulated IL-12p40 production. (+)-Medioresinol is a PGC-1α activator that protects against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. (+)-Medioresinol can be used in research on fungal and bacterial infection, inflammation, and ischemic stroke .
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Schisantherin B
Schisantherin B
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1 Cited Publications
Cat. No.: HY-N0695
CAS No.: 58546-55-7
Synonyms: Gomisin-B; Wuweizi ester-B; Schisantherin-B
Category:  

Plant Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenylpropanoids Schisandraceae Extract Disease Research Fields Inflammation/Immunology

Target:  

PI3K Akt mTOR GSK-3 Tau Protein TNF Receptor Interleukin Related Apoptosis

Schisantherin B (Gomisin-B) is a lignan compound and one of the active components of Schisandra chinensis. Schisantherin B activates the PI3K/AKT signaling pathway, restores the activity of GSK3β, and reduces the hyperphosphorylation of tau protein in hippocampal and cerebral cortical tissues. Schisantherin B upregulates the level of GLT-1, decreases the expression of pro-inflammatory cytokines TNF-α/IL-1β/IL-6, upregulates the expression of IL-10, and inhibits cell apoptosis. Schisantherin B is applicable to the research of spinal cord injury, Alzheimer's disease and depression .
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