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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
289 Results for "
lyase
" in MedChemExpress (MCE) Product Catalog:
Products (289)
289 Results for "lyase" in MCE Product Catalog:
28
28 Publications Verification
Cat. No.: HY-16450
CAS No.: 154566-12-8
Target:
Research Areas:
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.
27
Target:
Research Areas:
Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively.
26
26 Cited Publications
Cat. No.: HY-16107
CAS No.: 943962-47-8
Target:
Research Areas:
BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM.
25
25 Cited Publications
Synonyms: ETC-1002; ESP-55016
Target:
Research Areas:
Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK .
5
Research Areas:
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively . Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase . Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis . Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway . Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM . Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 µM .
3
3 Cited Publications
Cat. No.: HY-W017692
CAS No.: 1416354-35-2
Target:
Research Areas:
2-Aminoindan-2-phosphonic acid hydrochloride is a competitive phenylalanine ammonia lyase (PAL) inhibitor that significantly decreases the levels of total phenolic compounds and PheGs in plant cultured cells .
3
3 Cited Publications
Cat. No.: HY-P70968
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: OGG1; DNA-(Apurinic Or Apyrimidinic Site) lyase; 8-Oxoguanine DNA Glycosylase; DNA-Apurinic Or Apyrimidinic Site lyase; OGH1; OGG1 Type 1e; MUTM; OGG1 Type 1d; N-Glycosylase/DNA lyase; OGG1 Type 1g; HOGG1; OGG1 Type 1h; HMMH; OGG1 Type 1f; 8-Hydroxyguanin
Species:
Human
Source:
E. coli
3
3 Cited Publications
Cat. No.: HY-W004494
CAS No.: 141120-17-4
Target:
Research Areas:
2-Aminoindan-2-phosphonic acid is an inhibitor of phenylalanine ammonia-lyase (PAL). 2-Aminoindan-2-phosphonic acid reduces the biosynthesis and accumulation of total phenolic compounds in the suspension cell culture system of Cistanche .
3
3 Cited Publications
Target:
Research Areas:
OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1 .
3
3 Cited Publications
Target:
Research Areas:
TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions .
2
Target:
Research Areas:
Orteronel (TAK-700) is a highly selective inhibitor of human 17,20-lyase (CYP17) with IC50 of 38 nM, and exhibits >1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4 .
2
2 Cited Publications
Target:
Research Areas:
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate .
2
Elsulfavirine (R-1206) is an orally active human carbonic anhydrase (carbonic anhydrase, CA) inhibitor and an allosteric inhibitor of HIV-1 non-nucleoside reverse transcriptase (NNRT). Elsulfavirine also targets and blocks the interaction between adenylosuccinate lyase (ADSL) and insulin-induced gene proteins INSIG1/2, blocks SREBP-1-mediated de novo lipid synthesis, and inhibits the proliferation of liver cancer cells. The combination of Elsulfavirine and Lenvatinib (HY-10981) produces a synergistic anti-tumor effect. Elsulfavirine is converted into the active metabolite VM1500A in vivo, blocks the DNA polymerase activity of reverse transcriptase, and inhibits HIV-1 replication. Elsulfavirine exhibits a Ki of 1960 nM-52400 nM against human carbonic anhydrase isoforms including I, VII, VI, VA, VB, IX, XIII, XIV. Elsulfavirine is used in studies related to HIV-1 infection and liver cancer .
2
2 Cited Publications
Cat. No.: HY-P81223
Synonyms: Cholesterol 20 22 desmolase antibody
Cholesterol desmolase antibody;
Cholesterol monooxygenase (side chain cleaving) antibody;
Cholesterol side chain cleavage enzyme antibody;
Cholesterol side chain cleavage enzyme mitochondrial antibody;
Cholesterol side-chain cleavage enzyme antibody;
CP11A_HUMAN antibody;
CYP11A antibody;
CYP11A1 antibody;
CYPXIA1 antibody;
Cytochrome P450 11A1 antibody;
Cytochrome P450 11A1 mitochondrial antibody;
Cytochrome P450 family 11 subfamily A polypeptide 1 antibody;
Cytochrome P450 subfamily XIA antibody;
Cytochrome P450(scc) antibody;
Cytochrome P450C11A1 antibody;
mitochondrial antibody;
P450SCC antibody;
Steroid 20 22 lyase antibody;
1
1 Cited Publications
Target:
Research Areas:
Cystathionine-γ-lyase-IN-1 is a selective cystathionine γ-lyase (CSE) enzyme inhibitor with an IC50 of 6.3 μM . Cystathionine-γ-lyase-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
1
1 Cited Publications
Cat. No.: HY-16581A
Target:
Research Areas:
DL-threo-2-methylisocitrate sodium salt is a substrate of isocitrate lyase 1 (ICL1).
1
1
1 Cited Publications
Cat. No.: HY-P70025
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTH; Cysteine Desulfhydrase; Cystathionine Gamma-lyase; Gamma-Cystathionase; CSE; CGL; Cystathionase (Cystathionine Gamma-lyase); Homoserine Dehydratase; Cysteine-Protein Sulfhydrase; Homoserine Deaminase; Homocysteine Desulfhydrase
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-76293
CAS No.: 331963-29-2
I2906 is an orally active isocitrate lyase (ICL) inhibitor with a Mycobacterium tuberculosis IC50 of 134.3 μg/mL. I2906 inhibits the growth of Mycobacterium tuberculosis. I2906 can be used for the research of tuberculosis .
1
1 Cited Publications
Cat. No.: HY-P72338
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: OGG1; DNA-(Apurinic Or Apyrimidinic Site) lyase; 8-Oxoguanine DNA Glycosylase; DNA-Apurinic Or Apyrimidinic Site lyase; OGH1; OGG1 Type 1e; MUTM; OGG1 Type 1d; N-Glycosylase/DNA lyase; OGG1 Type 1g; HOGG1; OGG1 Type 1h; HMMH; OGG1 Type 1f; 8-Hydroxyguanin
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
