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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
lysosomal vesicles
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "lysosomal vesicles" in MCE Product Catalog:
1
Category:
Target:
Cat. No.: HY-P5423D
Cat. No.: HY-D3197
Cat. No.: HY-131595
CAS No.: 2074614-60-9
Synonyms: O-Methyl-serine dodecylamide hydrochloride
Research Areas:
MSDH (O-Methyl-serine dodecylamide hydrochloride) is a lysosomotropic detergent that targets the lysosomal membrane. MSDH enters cells via endocytosis, accumulates in lysosomes and becomes protonated, forming physiological pH vesicles that dissociate at acidic pH, and acts as a micellar detergent. MSDH induces lysosomal membrane permeabilization, deacidification, release of cathepsin D/B and β-N-acetylglucosaminidase, and translocation of galectins to lysosomes. MSDH induces apoptosis, necrosis, caspase-3 activation, a decrease in mitochondrial transmembrane potential, and elevated p62/LC3BII levels. MSDH can be used in research on non-alcoholic steatohepatitis and head and neck squamous cell carcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
