30

Ro 67-7476

30 Publications Verification

Cat. No.: HY-100403

CAS No.: 298690-60-5

Purity: 99.67%

Target:

mGluR

Research Areas:

Cancer

Ro 67-7476 is a potent positive allosteric modulator of mGluR₁ and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC₅₀ of 60.1 nM ^[1] . Ro 67-7476 is a potent P-ERK1/2 agonist and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC₅₀=163.3 nM) .

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4

DHPG

4 Cited Publications

Cat. No.: HY-12598A

CAS No.: 146255-66-5

Purity: 99.65%

Synonyms: (RS)-3,5-DHPG

Target:

mGluR

Research Areas:

Neurological Disease

DHPG is the agonist for mGluR 1/5 (EC₅₀ for mGluR 1 is 60 nM) that activates the phospholipase C (PLC) pathway, and leads ultimately to the activation of protein kinase C (PKC) ^[1].

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4

LY367385 hydrochloride

4 Cited Publications

Cat. No.: HY-107515A

CAS No.: 2829282-00-8

Purity: 99.47%

Target:

mGluR

Research Areas:

Neurological Disease

LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC₅₀ of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic effects ^[1] .

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4

LY367385

4 Cited Publications

Cat. No.: HY-107515

CAS No.: 198419-91-9

Purity: ≥99.0%

Target:

mGluR

Research Areas:

Neurological Disease

LY367385 is a highly selective and potent mGluR1a antagonist. LY367385 has an IC₅₀ of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects ^[1] .

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3

O-Phospho-L-serine

3 Cited Publications

Cat. No.: HY-15129

CAS No.: 407-41-0

Purity: 99.90%

Synonyms: L-Serine O-phosphate; L-SOP

Category:

Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Endogenous metabolite

Target:

mGluR Endogenous Metabolite

O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 ^[1].

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2

L-Cysteinesulfinic acid

2 Cited Publications

Cat. No.: HY-100804

CAS No.: 1115-65-7

Purity: 99.87%

Category:

Ketones, Aldehydes, Acids Endogenous metabolite

Target:

mGluR Endogenous Metabolite

L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively ^[1].

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2

L-Cysteinesulfinic acid monohydrate

2 Cited Publications

Cat. No.: HY-W017230

CAS No.: 207121-48-0

Category:

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields

Target:

mGluR Endogenous Metabolite

L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively ^[1].

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1

DL-AP3

1 Cited Publications

Cat. No.: HY-100786

CAS No.: 5652-28-8

Purity: ≥98.0%

Category:

Human Gut Microbiota Metabolites Natural Products Microorganisms Neurological Disease Endogenous metabolite Disease Research Fields Cancer

Target:

Endogenous Metabolite mGluR Phosphatase

DL-AP3 is a competitive mGluR1 and mGluR5 antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect ^[1] .

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1

AZD-8529

1 Cited Publications

Cat. No.: HY-107457

CAS No.: 1092453-15-0

Purity: 98.02%

Target:

mGluR

Research Areas:

Neurological Disease

AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC₅₀ of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.

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1

AZD-8529 mesylate

1 Cited Publications

Cat. No.: HY-107457A

CAS No.: 1314217-69-0

Purity: 99.63%

Target:

mGluR

Research Areas:

Neurological Disease

AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC₅₀ of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes ^[1].

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1

Ro 01-6128

1 Cited Publications

Cat. No.: HY-107507

CAS No.: 302841-86-7

Purity: 99.87%

Target:

mGluR

Research Areas:

Neurological Disease

Ro 01-6128 is a positive allosteric modulator of mGluR1 ^[1].

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(S)-3,5-DHPG

Cat. No.: HY-12598

CAS No.: 162870-29-3

Purity: ≥99.0%

Target:

mGluR

Research Areas:

Neurological Disease

(S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with K_i values of 0.9 μM and 3.9 μM for mGluR1a and mGluR5a, respectively ^[1]. (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia .

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