21

ALC-0159

21 Publications Verification

Cat. No.: HY-138300

CAS No.: 1849616-42-7

Purity: 99.93%

Target:

Liposome Drug Intermediate

Research Areas:

Others

ALC-0159 presents highly mobile surface PEG chains in a dense brush-like conformation, which can form a hydrophilic barrier, reduce non-specific protein adsorption and macrophage uptake, improve colloidal stability, prolong in vivo circulation time, and affect the cellular uptake of LNPs. ALC-0159 dissociates from the surface of mRNA-LNPs under long-term mechanical oscillation stress, thereby reducing steric hindrance, inducing mRNA-LNP fusion, increasing particle size, and releasing unencapsulated mRNA .

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2

CMLD-2

2 Cited Publications

Cat. No.: HY-124828

CAS No.: 958843-91-9

Purity: 98.66%

Target:

HuR

Research Areas:

Cancer

CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (K_i=350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation .

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1

N1-Methylpseudouridine-5′-triphosphate trisodium solution (100 mM)

1 Cited Publications

Cat. No.: HY-112582C

CAS No.: 3056945-59-3

Purity: 99.70%

Synonyms: 1-Methylpseudouridine-5′-triphosphate trisodium; N1-Me-Pseudo UTP trisodium; N1-Methyl-Pseudo-UTP trisodium

N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium solution (100 mM) is a nucleobase-modified nucleotide. N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium solution (100 mM) is used for synthesizing mRNA with reduced immunogenicity and improved stability .

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1

N4-Acetylcytidine

1 Cited Publications

Cat. No.: HY-W019670

CAS No.: 3768-18-1

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Histone Acetyltransferase Enterovirus NOD-like Receptor (NLR)

N4-acetylcytidine (N4A) is an endogenous nucleoside metabolite from the degradation of tRNA. N4-Acetylcytidine is formed by N-acetyltransferase 10 and other enzymes. N4-acetylcytidine might sustain NLRP3 inflammasome activation via induction of HMGB1 expression and releasee. N4-Acetylcytidine modifies mRNA, tRNA and rRNA, affecting their stability, translation efficiency (such as enterovirus 71 RNA). N4-Acetylcytidine is used in the study of cancer, neuroinflammatory diseases, viral infections and obesity .

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1

N1-Methylpseudouridine-5′-triphosphate solution (100 mM)

1 Cited Publications

Cat. No.: HY-112582A

CAS No.: 1428903-59-6

Synonyms: 1-Methylpseudouridine-5′-triphosphate

N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability.

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1

COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)

1 Cited Publications

Cat. No.: HY-153083

Target:

mRNA SARS-CoV

Research Areas:

Infection

COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) is an mRNA encoding the SARS-CoV-2 spike protein with enhanced performance via chemical modification. COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) replaces natural uridine (UTP) with N1-Me-Pseudo UTP, which effectively reduces immunogenicity and improves stability and translation efficiency. The 3' UTR of COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) optimizes AU-rich elements through HuR anchor sites, exhibiting higher translation efficiency. COVID-19 Spike Protein mRNA is widely used in COVID-19-related scientific research and vaccine development .

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1

SRI-42127

1 Cited Publications

Cat. No.: HY-148853

CAS No.: 2727872-68-4

Purity: 99.80%

Target:

HuR

Research Areas:

Others

SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes .

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