1510

1510 Publications Verification

Purity: 99.94%

Synonyms: Sirolimus; AY-22989; NSC 226080

Category:

Microorganisms Macrolide Antibiotics Anti-inflammation/Immunoregulatory Anti-aging Antibiotics Disease Research Disease Research Fields Cancer

Target:

mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial

Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant ^[1] .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

145

Torin 1

145 Cited Publications

Cat. No.: HY-13003

CAS No.: 1222998-36-8

Purity: 99.28%

Target:

mTOR Autophagy

Research Areas:

Cancer

Torin 1 is a potent inhibitor of mTOR with an IC₅₀ of 3 nM. Torin 1 inhibits both mTORC1/2 complexes with IC₅₀ values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

74

AZD-8055

74 Cited Publications

Cat. No.: HY-10422

CAS No.: 1009298-09-2

Purity: 99.60%

Target:

mTOR Autophagy Apoptosis

Research Areas:

Cancer

AZD-8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC₅₀ of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2 ^[1].

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

73

Dactolisib Tosylate

73 Cited Publications

Cat. No.: HY-15174

CAS No.: 1028385-32-1

Purity: 99.87%

Synonyms: BEZ235 Tosylate; NVP-BEZ 235 Tosylate

Target:

PI3K mTOR Autophagy

Research Areas:

Cancer

Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC₅₀ values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

73

Dactolisib

73 Cited Publications

Cat. No.: HY-50673

CAS No.: 915019-65-7

Synonyms: BEZ235; NVP-BEZ235

Target:

PI3K mTOR Autophagy

Research Areas:

Cancer

Dactolisib (BEZ235) is an orally active and dual pan-class I PI3K and mTOR kinase inhibitor with IC₅₀s of 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR, respectively. Dactolisib (BEZ235) inhibits both mTORC1 and mTORC2.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

69

Dactolisib hydrochloride

69 Cited Publications

Cat. No.: HY-50673A

CAS No.: 2319647-83-9

Synonyms: BEZ235 hydrochloride; NVP-BEZ235 hydrochloride

Target:

PI3K mTOR Autophagy

Research Areas:

Cancer

Dactolisib (BEZ235) hydrochloride is an orally active, dual pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR with IC₅₀ of 4 nM/5 nM/7 nM/75 nM and 20.7 nM, respectively. Dactolisib hydrochloride (BEZ235) inhibits mTORC1 and mTORC2 ^[1].

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

68

Daporinad

68 Cited Publications

Cat. No.: HY-50876

CAS No.: 658084-64-1

Synonyms: FK866; APO866

Target:

NAMPT Autophagy Apoptosis mTOR p38 MAPK ERK

Research Areas:

Cancer

Daporinad (FK866) is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a K_i value of 0.3 nM. Daporinad depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad causes the depletion of the endoplasmic reticulum Ca²⁺ pool, ultimately weakening the mitogen-induced Ca²⁺ signal and the activation and function of T cells. Daporinad induces cell cycle arrest and apoptosis, and inhibits cell proliferation. Daporinad can be used for the study of myeloma, liver cancer, and immunosuppression ^[1] .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

59

Sapanisertib

59 Cited Publications

Cat. No.: HY-13328

CAS No.: 1224844-38-5

Purity: 99.63%

Synonyms: INK-128; MLN0128; TAK-228

Target:

mTOR Apoptosis Akt ERK CDK Ribosomal S6 Kinase (RSK) Collagen HIF/HIF Prolyl-Hydroxylase Wnt

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

Sapanisertib (INK-128; MLN0128; TAK-228) is an orally active dual mTORC1/mTORC2 inhibitor. Sapanisertib directly and simultaneously inhibits mTORC1/2 activity through competitive binding with ATP, thereby comprehensively blocking downstream processes such as protein and lipid synthesis and cytoskeletal reorganization, consequently suppressing tumor cell proliferation and promoting apoptosis. Sapanisertib is applicable to research on melanoma, ovarian cancer, pulmonary fibrosis, and hematological malignancies ^[1] .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

34

Vistusertib

34 Cited Publications

Cat. No.: HY-15247

CAS No.: 1009298-59-2

Purity: 99.32%

Synonyms: AZD2014

Target:

mTOR Autophagy Apoptosis

Research Areas:

Cancer

Vistusertib (AZD2014) is an ATP competitive mTOR inhibitor with an IC₅₀ of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

33

PI-103

33 Cited Publications

Cat. No.: HY-10115

CAS No.: 371935-74-9

Purity: 99.82%

Target:

PI3K mTOR DNA-PK Autophagy Apoptosis

Research Areas:

Cancer

PI-103 is a potent PI3K and mTOR inhibitor with IC₅₀s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 also inhibits DNA-PK with an IC50 of 2 nM. PI-103 induces autophagy ^[1] .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

33

PI-103 Hydrochloride

33 Cited Publications

Cat. No.: HY-10115A

CAS No.: 371935-79-4

Purity: 98.55%

Target:

PI3K mTOR DNA-PK Autophagy Apoptosis

Research Areas:

Cancer

PI-103 Hydrochloride is a dual PI3K and mTOR inhibitor with IC₅₀s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 Hydrochloride also inhibits DNA-PK with an IC50 of 2 nM. PI-103 Hydrochloride induces autophagy ^[1] .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

31

Torkinib

31 Cited Publications

Cat. No.: HY-10474

CAS No.: 1092351-67-1

Purity: 99.03%

Synonyms: PP 242

Target:

mTOR Autophagy Mitophagy Apoptosis

Research Areas:

Cancer

Torkinib (PP 242) is a selective and ATP-competitive mTOR inhibitor with an IC₅₀ of 8 nM ^[1]. PP242 inhibits both mTORC1 and mTORC2 with IC₅₀s of 30 nM and 58 nM, respectively .

Compare

loading...