18 Results for "

marmoset

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "marmoset" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-108810
CAS No.: 914613-48-2
Purity:  99.64%
Synonyms: Ilaris; ACZ 885
Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin .
loading...
    loading...
Cat. No.: HY-121314
CAS No.: 40665-92-7
Research Areas:  

Metabolic Disease

Cloprostenol is a prostaglandin F-2α (PGF2α (HY-12956)) analogue. Cloprostenol induces luteolysis in marmoset monkeys. Cloprostenol can be used for the research of open-cervix pyometra .
loading...
    loading...
Cat. No.: HY-118956
CAS No.: 166591-11-3
Purity:  98.01%
Synonyms: ABT-431 hydrochloride; DAS-431 hydrochloride
Target:  

Dopamine Receptor

Research Areas:  

Neurological Disease

Adrogolide hydrochloride (ABT-431 hydrochloride) is a chemically stable prodrug that can convert to the dopamine D1 receptor agonist A-86929. Adrogolide hydrochloride ameliorates the MPTP (HY-15608)-induced Parkinson's Disease in marmoset model, reduces the dyskinesias tendency. Adrogolide hydrochloride reverses Risperidone (HY-11018)-induced cognitive deficits in monkey .
loading...
    loading...
Cat. No.: HY-P4990
CAS No.: 24327-19-3
Target:  

Oxytocin Receptor

Research Areas:  

Endocrinology

Pro8-Oxytocin is a a modified oxytocin (OXT) ligand. Pro8-Oxytocin produces more potent and efficacious responses at primate OXTR and stronger behavioral effects than the consensus mammalian OXT ligand (Leu8-Oxytocin). Pro8-Oxytocin produce a less efficacious response than Vasopressin (HY-B1811) (AVP) at human AVPR1a and higher efficacious response than AVP at marmoset AVPR1a .
loading...
    loading...
Cat. No.: HY-P991611
CAS No.: 3058434-76-4

Target:  

iGluR

Research Areas:  

Inflammation/Immunology

ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. ART5803 binds to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) with a high affinity. ART5803 blocks NMDAR internalization induced by pathogenic autoantibodies and restores cell-surface NMDAR expression and functions. ART5803 reverses behavioral abnormalities and NMDAR expression in marmoset disease models. ABT-147 can be used to study anti-NMDAR encephalitis .
loading...
    loading...
Cat. No.: HY-P4990A
Target:  

Oxytocin Receptor

Research Areas:  

Endocrinology

Pro8-Oxytocin TFA is a a modified oxytocin (OXT) ligand. Pro8-Oxytocin produces more potent and efficacious responses at primate OXTR and stronger behavioral effects than the consensus mammalian OXT ligand (Leu8-Oxytocin). Pro8-Oxytocin TFA produce a less efficacious response than Vasopressin (HY-B1811) (AVP) at human AVPR1a and higher efficacious response than AVP at marmoset AVPR1a .
loading...
    loading...
Cat. No.: HY-A0184
CAS No.: 126222-34-2
Synonyms: Ro 42-5892; Ro 42-5892/001
Target:  

Renin

Research Areas:  

Cardiovascular Disease

Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC50 values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension .
loading...
    loading...
Cat. No.: HY-125625
CAS No.: 116326-39-7
Target:  

Renin

Research Areas:  

Cardiovascular Disease

ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets .
loading...
    loading...
Cat. No.: HY-P991445

Target:  

SARS-CoV

Research Areas:  

Infection

REGN3051 is a human IgG1 monoclonal antibody (mAb) targeting MERS CoV. REGN3051 reduces viral titers in the lungs of mice expressing human DPP4. REGN3051 decreases lung disease severity and viral replication in marmosets inoculated with MERS-CoV. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
loading...
    loading...
Cat. No.: HY-100299A
CAS No.: 190841-57-7
RPR107393 is an orally active potent selective squalene synthase (SQS) inhibitor. RPR107393 inhibits rat liver microsomal squalene synthase with an IC50 value of 0.8 nM. RPR107393 reduces triglyceride biosynthesis by suppressing fatty acid biosynthesis via an increase in intracellular farnesol and its derivatives. RPR107393 reduces plasma cholesterol in rats and marmosets. RPR107393 can be used for metabolic disease research, such as hypercholesterolemia, hypertriglyceridemia and atherosclerosis .
loading...
    loading...
Cat. No.: HY-121550
CAS No.: 139958-16-0
ME3221 is an angiotensin AT1 receptor antagonist that effectively antagonizes the pressor response to angiotensin II in rats and marmosets without affecting the hypotensive response to bradykinin. It demonstrates potent antihypertensive effects in renal hypertensive rats and spontaneously hypertensive rats (SHR). ME3221's repeated administration in SHR results in sustained and stable hypotensive effects without affecting heart rate, indicating its potential for studying both renal and essential hypertension .
loading...
    loading...
Cat. No.: HY-100299
CAS No.: 197576-78-6
RPR107393 free base is an orally active potent selective squalene synthase (SQS) inhibitor. RPR107393 free base inhibits rat liver microsomal squalene synthase with an IC50 value of 0.8 nM. RPR107393 free base reduces triglyceride biosynthesis by suppressing fatty acid biosynthesis via an increase in intracellular farnesol and its derivatives. RPR107393 free base reduces plasma cholesterol in rats and marmosets. RPR107393 free base can be used for metabolic disease research, such as hypercholesterolemia, hypertriglyceridemia and atherosclerosis [1][2].
loading...
    loading...
Cat. No.: HY-171472
CAS No.: 171961-95-8
Target:  

Dopamine Receptor

Research Areas:  

Neurological Disease

A-86929 is a highly potent and selective dopamine D1 receptor agonist with a pKi value of 7.3. In the 6-OHDA (HY-B1081)-induced unilateral nigrostriatal lesion rat model, A-86929 significantly induces rotational behavior. It also improves motor function in the MPTP (HY-15608)-induced Parkinson's disease marmoset model. Additionally, A-86929 demonstrates potential therapeutic value in reducing cocaine-seeking behavior in rats and reversing Haloperidol (HY-14538)-induced cognitive deficits in rhesus monkeys. A-86929 can be used for research in neurological disorders .
loading...
    loading...
Cat. No.: HY-P78656
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LAG3; Lymphocyte-Activation Gene 3; Lymphocyte Activating 3; CD223 Antigen; CD223; LAG-3; Lymphocyte Activation Gene 3 Protein; FDC
Species:  
Marmoset
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P76418
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL17A; Cytotoxic T-Lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17A; Prev. IL17; CTLA-8; IL-17A; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17A; Cytotoxic T-Lymphocyte-Assoc
Species:  
Marmoset
Source:  
E. coli
loading...
    loading...
Cat. No.: HY-P77402
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL12B; Interleukin-12 Subunit Beta; Prev. NKSF2; Interleukin 12, P40; IL-12B; IL12, Subunit P40; CLMF2; IL-12 Subunit P40; NKSF; CLMF P40; CLMF; Cytotoxic Lymphocyte Maturation Factor 2, P40; Interleukin 12B (Natural Killer Cell Stimulatory Factor 2, Cyto
Species:  
Marmoset
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P72510
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HAVCR2; FLJ14428; Hepatitis A Virus Cellular Receptor 2; HAVcr-2; TIMD3; TIMD-3; TIM3; T-Cell Immunoglobulin And Mucin Domain 3; Tim-3; T Cell Immunoglobulin Mucin 3; CD366; Kidney Injury Molecule-3; T-Cell Immunoglobulin And Mucin Domain-Containing Prote
Species:  
Marmoset
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P73194
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: IL23A; Interleukin 23, Alpha Subunit P19; Interleukin 23 Subunit Alpha; Interleukin-23 Subunit Alpha; SGRF; Interleukin-23 Subunit P19; IL23P19; IL-23 Subunit Alpha; IL-23A; IL-23p19; IL-23; IL-23-A; P19; JKA3 Induced Upon T-Cell Activation; Interleukin-S
Species:  
Marmoset
Source:  
HEK293
loading...
    loading...
  • 1