73 Results for "

mdr1

" in MedChemExpress (MCE) Product Catalog:
Products (73)

73 Results for "mdr1" in MCE Product Catalog:

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9
CP-100356 hydrochloride
CP-100356 hydrochloride
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9 Publications Verification
Cat. No.: HY-108347
CAS No.: 142715-48-8
Purity:  99.19%
Target:  

P-glycoprotein BCRP

Research Areas:  

Metabolic Disease

CP-100356 hydrochloride is an orally active dual MDR1 (P-gp)/BCRP inhibitor, with an IC50s of 0.5 and 1.5 µM for inhibiting MDR1-mediated Calcein-AM transport and BCRP-mediated Prazosin transport, respectively. CP-100356 hydrochloride is also a weak inhibitor of OATP1B1 (IC50=∼66 µM). CP-100356 hydrochloride is devoid of inhibition against MRP2 and major human P450 enzymes (IC50>15 µM) [1].
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6
Bisantrene
Bisantrene
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6 Cited Publications
Cat. No.: HY-100875
CAS No.: 78186-34-2
Purity:  98.08%
Synonyms: CL216942
Target:  

Topoisomerase

Research Areas:  

Cancer

Bisantrene is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene targets eukaryotic type II topoisomerases. Bisantrene is a substrate of MDR1 [1] .
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6
Bisantrene dihydrochloride
Bisantrene dihydrochloride
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6 Cited Publications
Cat. No.: HY-100875A
CAS No.: 71439-68-4
Purity:  98.86%
Synonyms: CL-216942 dihydrochloride
Target:  

Topoisomerase

Research Areas:  

Cancer

Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1 [1] .
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4
Glycocholic acid
Glycocholic acid
0 Images
4 Cited Publications
Cat. No.: HY-N1423
CAS No.: 475-31-0
Category:  

Human Gut Microbiota Metabolites Endogenous metabolite Disease Research Fields Cancer Steroids

Target:  

P-glycoprotein Bcl-2 Family G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite Bacterial Apoptosis FXR Caspase MDM-2/p53 LPL Receptor

Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA) [1] .
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4
KT5720
KT5720
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4 Cited Publications
Cat. No.: HY-N6789
CAS No.: 108068-98-0
Target:  

PKA

Research Areas:  

Neurological Disease Cancer

KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor (IC50=3.3 μM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2 + concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases [1] .
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4
Glycocholic acid sodium
Glycocholic acid sodium
0 Images
4 Cited Publications
Cat. No.: HY-N1423A
CAS No.: 863-57-0
Category:  

Triterpenes Terpenoids Endogenous metabolite

Target:  

P-glycoprotein Bcl-2 Family G protein-coupled Bile Acid Receptor 1 Bacterial Apoptosis FXR Caspase MDM-2/p53 LPL Receptor Endogenous Metabolite

Glycocholic acid sodium is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid sodium inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid sodium modulates related bile acid receptor signaling. Glycocholic acid sodium suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid sodium can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA) [1] .
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4
CP-724714
CP-724714
0 Images
4 Cited Publications
Cat. No.: HY-14674
CAS No.: 383432-38-0
Purity:  98.72%
Target:  

EGFR Apoptosis P-glycoprotein Raf ERK

Research Areas:  

Infection Cancer

CP-724714 is an orally active and selective HER2 tyrosine kinase inhibitor with an IC50 of 10 nM. CP-724714 inhibits HER2 receptor autophosphorylation and blocks the downstream Ras-Raf-Mek-Erk signaling pathway, thereby inducing cell cycle arrest and apoptosis in tumor cells. CP-724714 exhibits antiviral activity and inhibits various porcine diarrheal coronaviruses, including SADS-CoV (IC50 of 0.91 μM). CP-724714 is an inhibitor of the hepatic transport receptors OATP1B1/MDR1/BSEP, and can enter hepatocytes via active uptake and trigger the accumulation of drugs and bile acids within hepatocytes. CP-724714 can be used in research related to HER2-overexpressing breast cancer and porcine diarrheal coronavirus infection [1] .
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4
Glycocholic acid hydrate
Glycocholic acid hydrate
0 Images
4 Cited Publications
Cat. No.: HY-N1423B
CAS No.: 1192657-83-2
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite Caspase G protein-coupled Bile Acid Receptor 1 LPL Receptor MDM-2/p53 Bcl-2 Family P-glycoprotein FXR Bacterial Apoptosis

Glycocholic acid hydrate is a bile acid derivative. Glycocholic acid hydrate downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid hydrate inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid hydrate modulates related bile acid receptor signaling. Glycocholic acid hydrate suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid hydrate can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA) [1] .
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2
Dofequidar
Dofequidar
0 Images
2 Cited Publications
Cat. No.: HY-17013
CAS No.: 129716-58-1
Synonyms: MS-209 free base
Target:  

P-glycoprotein

Research Areas:  

Cancer

Dofequidar (MS-209 free base) is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect [1] .
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2
Bifendate
Bifendate
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2 Cited Publications
Cat. No.: HY-W018791
CAS No.: 73536-69-3
Synonyms: DDB
Target:  

HBV Autophagy Cytochrome P450 Atg8/LC3 p62 P-glycoprotein

Research Areas:  

Infection Cardiovascular Disease Cancer

Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR) .
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2
Dofequidar fumarate
Dofequidar fumarate
0 Images
2 Cited Publications
Cat. No.: HY-17013A
CAS No.: 153653-30-6
Synonyms: MS-209
Target:  

P-glycoprotein

Research Areas:  

Cancer

Dofequidar fumarate (MS-209) is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar fumarate has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar fumarate competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect [1] .
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2
P Glycoprotein Antibody (YA255)
P Glycoprotein Antibody (YA255)
0 Images
2 Cited Publications
Cat. No.: HY-P80772
Synonyms: p-pg; PGP; ABCB1; mdr1; PGY1; Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD antigen CD243

Host:  

Rabbit

Application:  

WB, IHC-P

Reactivity:  

Human

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1
ABCB1 Protein, Human (HEK293, Flag)
ABCB1 Protein, Human (HEK293, Flag)
0 Images
1 Cited Publications
Cat. No.: HY-P703175
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ABCB1; P-170; Prev. PGY1; ATP-Dependent Translocase ABCB1; Prev. mdr1; Phospholipid Transporter ABCB1; Prev. CLCS; Colchicin Sensitivity; Multidrug Resistance Protein 1; ATP-Binding Cassette Sub-Family B Member 1; ATP-Binding Cassette, Sub-Family B (mdr/T
Species:  
Human
Source:  
HEK293
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Bicyclol
Bicyclol
0 Images
Cat. No.: HY-B0766
CAS No.: 118159-48-1
Synonyms: SY801
Target:  

Autophagy Apoptosis HBV HCV HSP Reactive Oxygen Species (ROS) Bcl-2 Family Glutathione S-transferase p38 MAPK NF-κB Microtubule/Tubulin ERK JNK TNF Receptor Interleukin Related CDK Cyclin G-associated Kinase (GAK) mTOR P-glycoprotein Ferroptosis

Research Areas:  

Infection Inflammation/Immunology Cancer

Bicyclol (SY801) is an orally active derivative of the traditional Chinese medicine Schisandra chinensis, which has antiviral, anti-inflammatory, immunomodulatory, antioxidant, anti-steatosis, anti-fibrotic and anti-tumor activities. Bicyclol regulates the expression of heat shock proteins and plays an anti-apoptosis role in hepatocytes. Bicyclol reduces the activation of NF-κB and the levels of inflammatory factors in hepatocytes infected with hepatitis C virus (HCV) by inhibiting the activation of the ROS-MAPK-NF-κB pathway, and prevents ferroptosis in acute liver injury. Bicyclol can change the expression of Mdr-1, GSH/GST and Bcl-2, increase the intracellular concentration of anticancer drugs, and sensitize drug-resistant cells to anticancer drugs. Bicyclol inhibits the proliferation of human malignant hepatoma cells by regulating the PI3K/AKT pathway and the Ras/Raf/MEK/ERK pathway. Bicyclol can be used in the study of chronic hepatitis, acute liver injury, nonalcoholic fatty liver disease, liver fibrosis and hepatocellular carcinoma [1] .
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Glycocholic acid-d4
Glycocholic acid-d4
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Cat. No.: HY-N1423S
CAS No.: 1201918-15-1
Glycocholic acid-d4 is the deuterium labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).
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TTT-28
TTT-28
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Cat. No.: HY-101511
CAS No.: 1609138-51-3
Purity:  99.62%
Target:  

P-glycoprotein

Research Areas:  

Cancer

TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1)-mediated multidrug resistance (MDR) by selectively blocking the efflux function of ABCB1 [1].
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IDOR-1117-2520
IDOR-1117-2520
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Cat. No.: HY-162495
CAS No.: 2737274-49-4
Target:  

CCR Calcium Channel Arrestin P-glycoprotein

Research Areas:  

Inflammation/Immunology Cancer

IDOR-1117-2520 is an orally active, potent, selective and reversible CCR6 antagonist. IDOR-1117-2520 antagonizes the CCL20-mediated calcium flow (IC50 = 63 nM) and inhibits β-arrestin recruitment to human CCR6 (IC50 = 30 nM) in cells expressing recombinant human CCR6. IDOR-1117-2520 is found to be a substrate of P-gp/MDR1. IDOR-1117-2520 can be used in the research of autoimmune diseases and skin inflammation [1] .
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Isosinensetin
Isosinensetin
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Cat. No.: HY-N1941
CAS No.: 17290-70-9
Category:  

Flavonoids Flavones Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:  

P-glycoprotein Bacterial HIV Protease Phosphatase Reactive Oxygen Species (ROS) NF-κB p38 MAPK ERK JNK Calcium Channel

Isosinensetin is a flavonoid compound and an inhibitor of HIV-1 protease and PTP1B (IC50: 2.61 µM; Ki: 0.92 µM). Isosinensetin inhibits P-glycoprotein (P-gp) in MDR1-MDCKII cells. Isosinensetin has multiple activities such as anti-tumor, anti-viral, anti-inflammatory, and antioxidant effects. Isosinensetin can be used in the research of various diseases including cancer, inflammation, osteoporosis, diabetes, etc [1] .
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Byakangelicin
Byakangelicin
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Cat. No.: HY-N6022
CAS No.: 482-25-7
Category:  

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